Abstract:
:Advanced glycation endproducts (AGEs) are the products of non-enzymatic glycation and oxidation of proteins and lipids. Low-turnover tissues such as articular cartilage seem to be susceptible to the accumulation of AGEs, which might lead to cartilage degradation. Recently, a non-invasive method for measuring skin AGE accumulation was developed by using the Autofluorescence Reader (AFR). To examine the usefulness of measuring skin AGE in patients with bone and joint diseases, we examined autofluorescence (AF) levels in skin of patients with osteoarthritis (OA), rheumatoid arthritis (RA), and dialysis-related spondyloarthropathy (DRSA). Ninety-three patients with RA, 24 patients with OA, and 29 patients with DRSA were examined, and 43 healthy volunteers were used as controls. Skin AF was assessed on the lower arm with the AGE-Reader. Mean AF was significantly higher in the patients with RA (median 2.13 and range 1.25-2.94) or with DRSA (median 2.21 and range 1.29-3.88) than in the patients with OA (median 1.63 and range 1.07-2.31) or in the controls (median 1.74 and range 1.10-2.46). There was no significant difference between OA and the controls, or between RA and DRSA. These findings suggest that differences of AGE accumulation in the skin might reflect the different pathologies of these diseases.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Matsumoto T,Tsurumoto T,Baba H,Osaki M,Enomoto H,Yonekura A,Shindo H,Miyata Tdoi
10.1007/s00296-007-0408-4subject
Has Abstractpub_date
2007-12-01 00:00:00pages
157-60issue
2eissn
0172-8172issn
1437-160Xjournal_volume
28pub_type
杂志文章abstract::The objective of this study was to compare rheumatoid arthritis (RA) disease activity and patient-reported outcomes (PROs) in a national sample of patients with RA with/without Sjögren's syndrome (SS). Adults with RA from a large observational US registry (Corrona RA) with known SS status between 22 April 2010 and 31 ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04602-8
更新日期:2020-08-01 00:00:00
abstract::Polyarteritis nodosa (PAN) is a rare systemic vasculitis affecting multiple organs. Current standard treatment includes the use of glucocorticoids and cyclophosphamide. Unfortunately, some patients do not respond to this treatment and other therapeutic options are needed. We present a case of a young male with refract...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4210-2
更新日期:2019-02-01 00:00:00
abstract::The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s002960050066
更新日期:1998-01-01 00:00:00
abstract::During the coronavirus disease-2019 (COVID-19) pandemic there were several barriers to treatment access and medication adherence in rheumatoid arthritis (RA) patients. There is no information regarding the RA patient health status in Egypt during the COVID-19. Thus,the aim of this work was to study the impact of the p...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04736-9
更新日期:2021-02-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that can lead to damage to several vital organs. Antiphospholipid syndrome (APS), manifesting as vascular thromboembolic events and morbidities of pregnancy in the presence of antiphospholipid antibodies (aPL), has been described in patients with SLE...
journal_title:Rheumatology international
pub_type: 信件
doi:10.1007/s00296-011-1826-x
更新日期:2012-03-01 00:00:00
abstract::The purpose of this study was to determine the association of fibromyalgia (FM) with temporomandibular disorder (TMD) and masticatory myofascial pain (MMP). Thirty-one consecutive women diagnosed as having FM according to American College of Rheumatology criteria and 21 consecutive women diagnosed as having TMD were i...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0251-z
更新日期:2007-04-01 00:00:00
abstract::We have investigated the prevalence of dry mouth among patients with autoimmune diseases other than Sjögren's syndrome. One hundred and forty-four patients, excluding patients with primary Sjögren's syndrome, were enrolled in this study. The volume of saliva secreted was measured with the screening technique for estim...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2611-1
更新日期:2013-12-01 00:00:00
abstract::Sixty-six hospitalized patients with systemic lupus erythematosus (SLE) were enrolled into this study. The test for anti-mitochondrial antibodies (AMAs) was performed and biochemical parameters were determined. AMAs were detected in 15 of the 66 patients with SLE. Meanwhile, we compared enzymatic levels in AMA-positiv...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0034-y
更新日期:2006-06-01 00:00:00
abstract:UNLABELLED:The objective of this study is to provide a critical overview of available instruments to assess impairments in patients with rheumatic disorders, and to recommend reliable and valid instruments for use in allied health care and rehabilitation medicine. A computer-aided literature search (1982-2004) in sever...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-005-0603-0
更新日期:2005-09-01 00:00:00
abstract::Methotrexate (MTX) can be toxic to patients suffering from end stage renal disease (ESRD) on hemodialysis even at low doses. This increase in toxicity is more notable in terms of bone marrow suppression in the form of pancytopenia. Many methods of elimination including dialysis itself have been proven ineffective, and...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-011-2041-5
更新日期:2011-12-01 00:00:00
abstract::Polyarteritis nodosa (PAN) related to hepatitis B is an uncommon vasculitis that is sometimes associated with the rapid progression of distal ischemia. A few recent reports have proposed the use of antiviral therapy. However, there is not yet a consensus for the standard treatment of this disease entity and none of th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0103-x
更新日期:2006-08-01 00:00:00
abstract::The aim of this study was to compare the efficacy of sodium hyaluronate (SH) injection with the most common treatment methods, intraarticular steroid injection and physical therapy modalities in patients with adhesive capsulitis (AC). A total of 95 shoulders of 90 patients were included in the study and were randomize...
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-005-0022-2
更新日期:2006-04-01 00:00:00
abstract::Some children with malignancy (e.g. acute lymphoblastic leukemia) who initially present with musculoskeletal complaints may be misdiagnosed as having a rheumatological disorder. In the literature, importance has been given to subtle changes in blood counts, which may point toward an underlying malignancy. We report 3 ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1584-1
更新日期:2011-06-01 00:00:00
abstract::As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibr...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-007-0403-9
更新日期:2007-09-01 00:00:00
abstract::Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1395-4
更新日期:2012-05-01 00:00:00
abstract::31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00291145
更新日期:1991-01-01 00:00:00
abstract::Behçet's disease (BD) is a variable vessel vasculitis characterized by recurrent oral and genital aphthosis accompanied by skin, ocular, gastrointestinal, neurologic, and articular involvement. BD is not common in childhood and the disease characteristics considerably differ between adults and children. 18 diagnostic/...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4208-9
更新日期:2019-01-01 00:00:00
abstract::Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test-retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese-Brazil WOMAC ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04496-1
更新日期:2020-02-01 00:00:00
abstract::There is no agreement among the rheumatology community in how to implement the musculoskeletal ultrasound (MSUS) technique in the Rheumatology Divisions. To test the perceived usefulness of the MSUS, under consensus indications, for referring colleagues for the clinical management of their patients with inflammatory a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3538-8
更新日期:2016-12-01 00:00:00
abstract::In recent years, scientific efforts on the topic "gout" have focused on pathogenetic aspects. This has opened new strategies of anti-inflammatory therapy and has improved urate-lowering therapy. So far, a scientometric analysis of the topic "gout" has not been generated despite an increased need for it in times of mod...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2805-1
更新日期:2013-11-01 00:00:00
abstract::Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4102-5
更新日期:2018-09-01 00:00:00
abstract::Previous studies showed a link between systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection. We sought to determine the features of serologic response to EBV in SLE patients and whether this response differs from those of systemic sclerosis (SSc) and primary antiphospholipid syndrome (PAPS) patien...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1573-4
更新日期:2012-01-01 00:00:00
abstract::The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia. The aim of this study was to jointly address and integrate these se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1705-x
更新日期:2012-03-01 00:00:00
abstract::The aim of the study is to study the relationship between androgen levels and bone mineral density (BMD) in elderly Arab males. Forty-five elderly Arab males underwent Dual X-ray absorptiometry for measurement of BMD. The outcomes were defined as per WHO description. Assays for testosterone (T), gonadotropins (LH and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0970-z
更新日期:2010-01-01 00:00:00
abstract::A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270365
更新日期:1987-01-01 00:00:00
abstract::The objective of this study was to evaluate human papillomavirus (HPV) and Chlamydia trachomatis (CT) infections in RA patients pre- and post-TNF blocker. Fifty female RA patients (ACR criteria), who were eligible to anti-TNF therapy [n = 50 at baseline (BL) and n = 45 after 6 months of treatment (6 M)], and 50 age-ma...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3157-1
更新日期:2015-03-01 00:00:00
abstract::Among the clinical manifestations of systemic lupus erythematosus is an arthropathy, which is usually non-erosive. In many cases, the joint involvement is mild. A subset of patients has deforming, non-erosive Jaccoud's arthropathy, and a minority have an arthropathy with clinical findings similar to rheumatoid arthrit...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-008-0780-8
更新日期:2009-08-01 00:00:00
abstract::Accumulating evidence suggests that defects in the function of CD4(+)CD25(+) regulatory T cells (Tregs) are important in immune-mediated diseases such as rheumatoid arthritis. Here, we investigated the effects of various disease-modifying anti-rheumatic drugs (DMARDs) on Treg function. Tregs and CD4(+)CD25(-) effector...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2365-9
更新日期:2013-02-01 00:00:00
abstract::The efficacy of balneotherapy in fibromyalgia syndrome (FS) has been well demonstrated, while controlled studies using mud packs are lacking. We performed a randomized clinical trial to evaluate the effects and the tolerability of mud-bath treatment in FS patients, who are poor responders to pharmacological therapy. E...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00296-007-0358-x
更新日期:2007-10-01 00:00:00
abstract::Most infectious agents, such as viruses, bacteria and parasites, can trigger autoimmunity via different mechanisms. The development of an autoimmune disorder after infection tends to occur in genetically susceptible individuals. Some parameters, such as genetic predisposition, feature of the infectious agent and somet...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-012-2451-z
更新日期:2012-11-01 00:00:00