A spontaneous intercostal artery hemorrhage in systemic lupus erythematosus.


:Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that can lead to damage to several vital organs. Antiphospholipid syndrome (APS), manifesting as vascular thromboembolic events and morbidities of pregnancy in the presence of antiphospholipid antibodies (aPL), has been described in patients with SLE. Catastrophic antiphospholipid syndrome (CAPS), in contradistinction to APS, is defined as three or more organs affected by thrombotic microangiopathy in patients demonstrating aPL and can result in mortality up to 50%. We describe a unique SLE patient who was diagnosed with recurrent APS presented with axillary venous thrombosis and subsequent superficial edema and compartment syndrome. The CAPS followed and revealed thromboses over liver, spleen, and acute pancreatitis. The spontaneous hemorrhage of left fourth intercostal artery (ICA) and left axillary artery occured at the same time without vasculitis or severe trauma. Though emergency transcatheter arterial embolization (TAE) of the left fourth ICA was successfully accomplished by the radiologist. The repeated computed tomography angiogram of chest demonstrated remission of ruptured ICA. Nevertheless, the patient died of diffuse alveolar hemorrhage and respiratory failure and shock. Both disseminated intravascular coagulation (DIC) and CAPS share similar characteristics encompassing thrombotic microangiopathy, bleeding, thromboembolism, and multiple organ dysfunction. It is difficult to distinguish between them, especially in cases such as our uremic SLE patient with a calamitous disease progression. The emphasis of treatment for DIC is on platelet and fresh plasma transfusion, in contrast with anti-coagulant for CAPS. To the best of our knowledge, this is the first report describing ICA hemorrhage in an SLE patient without vasculitis or aneurysm. The lupus flare initiated a pathological immunological cascade and resulted in the CAPS and the vascular damage.


Rheumatol Int


Lu CC,Chen CH,Yeh SF,Lai JH,Chang DM




Has Abstract


2012-03-01 00:00:00












  • Higher levels of serum interleukin-35 are associated with the severity of pulmonary fibrosis and Th2 responses in patients with systemic sclerosis.

    abstract::The aim of the study is to investigate the levels of serum interleukin-35 (IL-35) before and after treatment and its relationship with clinical parameters as well as the frequency of different subsets of CD4+ T cells in patients with systemic sclerosis (SSc) to explore the role of IL-35 in the pathogenesis of SSc. The...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Tang J,Lei L,Pan J,Zhao C,Wen J

    更新日期:2018-08-01 00:00:00

  • Acute pseudogout of the neck--the crowned dens syndrome: 2 case reports and review of the literature.

    abstract::Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Siau K,Lee M,Laversuch CJ

    更新日期:2011-01-01 00:00:00

  • Identification and purification of a 55K polypeptide in Sjögren's syndrome A antigen.

    abstract::The Sjögren's syndrome A antigen (SS-A) purified by affinity chromatography from human spleen was shown to contain a major polypeptide with a mol. wt. of 55 000 daltons confirmed as SS-A by its reactivity with different anti-SS-A sera on affinity columns, immunodiffusion and the Western blot. A similar reactive polype...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Smith PR,Venables PJ,Williams D,Maini RN

    更新日期:1984-01-01 00:00:00

  • Cartilage collagen type II seromarker patterns in axial spondyloarthritis and psoriatic arthritis: associations with disease activity, smoking and HLA-B27.

    abstract::The aim of the study was to assess the possible association between type II collagen turnover seromarkers and disease profile in patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). Outpatients with axial SpA (n = 110) or PsA (n = 101) underwent clinical examination including disease activity mea...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Munk HL,Gudmann NS,Christensen AF,Ejstrup L,Sorensen GL,Loft AG,Bay-Jensen AC,Siebuhr AS,Junker P

    更新日期:2016-04-01 00:00:00

  • Paleopathological interpretations of hypermobility syndrome in the art from ancient America.

    abstract::Paleopathological representations of hypermobility syndrome were assumed in pre-Columbian artifacts from different ancient civilizations from America. Anthropomorphic sculptures from several museums and galleries visited on site or thru Internet show the human figure in contorted positions. These positions are only po...

    journal_title:Rheumatology international

    pub_type: 历史文章,杂志文章


    authors: Checa A

    更新日期:2012-10-01 00:00:00

  • Acute pancreatitis and macrophage activation syndrome in pediatric systemic lupus erythematosus: case-based review.

    abstract::Pancreatitis is uncommon in systemic lupus erythematosus (SLE) and is rarely reported in children, possibly being related to macrophage activation syndrome (MAS). The incidence of MAS in children with lupus pancreatitis is unknown, as is their prognosis. In this case-based review, we report a pediatric patient with SL...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Lin Q,Zhang M,Tang H,Shen Y,Zhu Y,Xu Q,Li X

    更新日期:2020-05-01 00:00:00

  • Evidence-based use of methotrexate in children with rheumatic diseases: a consensus statement of the Working Groups Pediatric Rheumatology Germany (AGKJR) and Pediatric Rheumatology Austria.

    abstract::Juvenile idiopathic arthritis (JIA) is the most common diagnosis in children and adolescents with rheumatic disorders. In many children and adolescents, JIA is successfully treated with non-steroidal anti-inflammatory drugs (NSAID) and physiotherapy. However, in a significant number of cases the disease is resistant t...

    journal_title:Rheumatology international

    pub_type: 杂志文章,实务指引


    authors: Niehues T,Horneff G,Michels H,Höck MS,Schuchmann L,Working Groups Pediatric Rheumatology Germany (AGKJR).,Pediatric Rheumatology Austria.

    更新日期:2005-04-01 00:00:00

  • Associations of cigarette smoking with disease phenotype and type I interferon expression in primary Sjögren's syndrome.

    abstract::Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patie...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Olsson P,Bodewes ILA,Nilsson AM,Turesson C,Jacobsson LTH,Theander E,Versnel MA,Mandl T

    更新日期:2019-09-01 00:00:00

  • Gaps between research and recommendations in rheumatoid arthritis.

    abstract:OBJECTIVES:To identify recommendations on the diagnosis and management of rheumatoid arthritis (RA) supported by low recommendation grades, to study the causes of this low grading, and to propose solutions. METHODS:A group of six rheumatologists, with extensive experience in the development of systematic reviews, revi...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ortiz AM,Silva Fernández L,Villaverde V,Abad MÁ,Maneiro JR,Candelas G,Gómez S,Valderrama M,Montoro M

    更新日期:2021-01-01 00:00:00

  • Comparison of phenotype expression by mononuclear phagocytes within subcutaneous gouty tophi and rheumatoid nodules.

    abstract::The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evid...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Palmer DG,Hogg N,Denholm I,Allen CA,Highton J,Hessian PA

    更新日期:1987-01-01 00:00:00

  • Intracranial manifestations in SAPHO syndrome: the first case report in literature.

    abstract::A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and h...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Abul-Kasim K,Nilsson T,Turesson C

    更新日期:2012-06-01 00:00:00

  • Effectiveness of ultrasound treatment applied with exercise therapy on patients with ankylosing spondylitis: a double-blind, randomized, placebo-controlled trial.

    abstract::The aim of our study was to evaluate effectiveness of ultrasound treatment applied with exercise therapy in patients with ankylosing spondylitis. Fifty-two patients, who were diagnosed according to modified New York criteria, were aged 25-60, and have spine pain, were randomly assigned to two groups. Ultrasound (US) a...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验


    authors: Şilte Karamanlioğlu D,Aktas I,Ozkan FU,Kaysin M,Girgin N

    更新日期:2016-05-01 00:00:00

  • Noninvasive assessment of impaired endothelial dysfunction in mucocutaneous Behçet's disease.

    abstract::Noninvasive assessment of endothelial dysfunction (ED) and diagnosing the early vascular development of atherosclerosis in active mucocutaneous Behçet's disease. Twenty-nine active BD patients (study group) without any obstructive vascular involvement were compared with twenty-nine healthy controls (control group) in ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ulusoy RE,Karabudak O,Kilicaslan F,Kirilmaz A,Us MH,Cebeci BS

    更新日期:2008-05-01 00:00:00

  • Temporomandibular disorders in ankylosing spondylitis: a cross-sectional, monocentric study.

    abstract::There are contradictory results in the relevant literature about the relationship between objective determinants of craniocervical posture and temporomandibular disorder (TMD), whereas no study has worked on ankylosing spondylitis (AS) and TMD relationship. We conducted this study to test the predictors of TMD in AS p...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bilgin E,Bilgin E,Özdemir O,Kalyoncu U

    更新日期:2020-06-01 00:00:00

  • Association of rheumatoid arthritis with hearing loss: a systematic review and meta-analysis.

    abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting up to 1% of the worldwide population. RA is associated with multiple extra-articular manifestations (EAMs). Middle ear, cochlea and the auditory nerve are suspected sites of RA activity and hearing loss is a possible novel EAM of RA. Objective was to...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Chaitidis N,Theocharis P,Festas C,Aritzi I

    更新日期:2020-11-01 00:00:00

  • Current understanding and future perspectives of brain-heart-kidney axis in psoriatic arthritis.

    abstract::Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA reve...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Markousis-Mavrogenis G,Nurmohamed MT,Koutsogeorgopoulou L,Dimitroulas T,Katsifis G,Vartela V,Mitsikostas D,Kolovou G,Tektonidou M,Voulgari P,Sfikakis PP,Kitas GD,Mavrogeni SI

    更新日期:2020-09-01 00:00:00

  • Absence of salivary CCL28 in primary Sjögren's syndrome.

    abstract::CCL28 is a mucosa-associated epithelial-cell-produced chemokine involved in oral defense. We assessed the level of CCL28 in saliva of primary Sjögren's syndrome (pSS) patients in comparison with healthy controls and correlated it with IgA salivary levels. We included 30 non-smoker pSS patients and 30 non-smoker health...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Hernandez-Molina G,Burkhardt AM,Lima G,Zlotnik A,Betanzos JL,Bahena S,Llorente L

    更新日期:2015-08-01 00:00:00

  • Hand osteoarthritis in Chuvashian population: prevalence and determinants.

    abstract::The objectives of this study are to evaluate the prevalence of radiographic hand osteoarthritis (OA) in Chuvashian community-based sample and its associations with age, sex, body mass index (BMI), smoking, and alcohol consumption. The study population was comprised of Chuvashians (443 males, age 47.4 ± 17.0 years and ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kalichman L,Kobyliansky E

    更新日期:2009-11-01 00:00:00

  • Catalase and PPARgamma2 genotype and risk of rheumatoid arthritis in Koreans.

    abstract::Catalase (CAT) and peroxisome proliferator activated receptor-gamma2 (PPARgamma2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARgamma2 genotypes and risk and severity of RA using 474...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: El-Sohemy A,Cornelis MC,Park YW,Bae SC

    更新日期:2006-03-01 00:00:00

  • Pristane-induced arthritis in Balb/c mice. I. Clinical and histological features of the arthropathy.

    abstract::Intraperitoneal injection of pristane induced a clinical peripheral arthritis and/or tenosynovitis in 40% of 40 Balb/cJ/Ola mice. Hind paws were always affected first and fore paws were frequently involved. Involvement of knee joints was only apparent histologically. Some clinically unaffected animals and apparently u...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Hopkins SJ,Freemont AJ,Jayson MI

    更新日期:1984-01-01 00:00:00

  • Hypokalemic periodic paralysis in Sjogren's syndrome secondary to distal renal tubular acidosis.

    abstract::We report a 53-year-old Turkish female presented with progressive weakness and mild dyspnea. Laboratory results demonstrated severe hypokalemia with hyperchloremic metabolic acidosis. The urinary anion gap was positive in the presence of acidemia, thus she was diagnosed with hypokalemic paralysis from a severe distal ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Yılmaz H,Kaya M,Özbek M,ÜUreten K,Safa Yıldırım İ

    更新日期:2013-07-01 00:00:00

  • Hydroxychloroquine ototoxicity in a patient with rheumatoid arthritis.

    abstract::We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Seçkin U,Ozoran K,Ikinciogullari A,Borman P,Bostan EE

    更新日期:2000-01-01 00:00:00

  • Hypothermia induced by adenosine 5'-monophosphate attenuates early stage injury in an acute gouty arthritis rat model.

    abstract::To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Miao Z,Guo W,Lu S,Lv W,Li C,Wang Y,Zhao S,Yan S,Tao Z,Wang Y

    更新日期:2013-08-01 00:00:00

  • Association study of estrogen receptor alpha gene polymorphisms with bone mass assessed by quantitative ultrasound in young adults.

    abstract::Different genetic variants in estrogen receptor alpha (ESR1) have been shown to influence bone phenotypes including quantitative bone ultrasound in elderly. We aimed to investigate the role of ESR1 polymorphisms in bone mass assessed by calcaneal quantitative ultrasound (QUS) in a population of young adults. The study...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Correa-Rodriguez M,Schmidt-RioValle J,Rueda-Medina B

    更新日期:2017-08-01 00:00:00

  • Secondary amyloidosis in ankylosing spondylitis.

    abstract::We evaluated the frequency of secondary amyloidosis, associated clinical features, and outcomes in ankylosing spondylitis (AS) patients diagnosed in the last decade. The medical records of AS patients diagnosed at single academic medical center were reviewed for clinical evidence of amyloidosis. During routine follow-...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Dönmez S,Pamuk ÖN,Pamuk GE,Aydoğdu E,Inman R

    更新日期:2013-07-01 00:00:00

  • Association between daily level of objective physical activity and C-Reactive protein in a representative national sample of adults with self-reported diagnosed arthritis or fibromyalgia.

    abstract:PURPOSE:Examine the association between physical activity and sedentary time with high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. We also investigated the dose of physical activity that was associated with lower clinical levels of high sensitivity C-Reactive protein (< 3 mg/L). MA...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kingsbury C,Karelis AD,Hains-Monfette G,Bernard P

    更新日期:2020-09-01 00:00:00

  • The expression of PADI4 in synovium of rheumatoid arthritis.

    abstract::PADI4 that catalyzes the conversion of peptidylarginine to citrulline is associated with rheumatoid arthritis in some populations. The current study investigated the expressions of PADI4 in synovial fluid of RA (n = 73), osteoarthritis (OA, n = 96) and ankylosing spondylitis (AS, n = 32) using ELISA and western blotti...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Chang X,Zhao Y,Sun S,Zhang Y,Zhu Y

    更新日期:2009-10-01 00:00:00

  • Association between disease activity measured by RAPID3 and health-related quality of life in patients with rheumatoid arthritis.

    abstract::Routine assessment of patient index data 3 (RAPID3) is a simple, valid and reliable tool designed to measure disease activity in patients with rheumatoid arthritis (RA). RA causes significant disability and diminishes health-related quality of life (HR-QoL). The aim of this study was to investigate how RAPID3 is relat...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Qorolli M,Rexhepi B,Rexhepi S,Mustapić M,Doko I,Grazio S

    更新日期:2019-05-01 00:00:00

  • Parenchymal neuro-Behçet disease with erectile dysfunction and micturition disturbances: case report and literature review.

    abstract::Parenchymal neuro-Behçet disease (NBD) is a serious clinic condition with a sub-acute or chronic disease course that results in incapability through pyramidal tract involvement. Though well-known consequences can deter a patient's life, both urinary symptoms and sexual dysfunction are underestimated complications of N...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Taylan A,Birlik M

    更新日期:2018-01-01 00:00:00

  • Can clodronate be effective in the treatment of disabling hydroxyapatite crystal-deposition disease? A report of two cases.

    abstract::Hydroxyapatite crystals are often deposited in the vicinity of joints, where they can cause a clinical periarthritis. Clodronate is a first-generation bisphosphonate that has the ability to reduce ectopic calcifications. Two women were affected by disabling calcific periarthritis of the shoulders lasting for years and...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Saviola G,Abdi-Ali L,Baiardi P,Benucci M

    更新日期:2011-03-01 00:00:00