Abstract:
:A critical analysis has been performed of reports published on the incidence of gastro-intestinal (GI) side-effects found in arthritic patients being treated with non-steroid anti-inflammatory (NSAI) drugs. The results show the following: 1. The incidence of GI ulceration (as revealed by gastroscopy) and haemorrhage in arthritic patients taking NSAI drugs may be higher than suspected from clinical trial data. 2. Incidence of all GI side-effects (including ulceration and haemorrhage) may be lower with some of the new NSAI drugs than with traditional drugs (e.g. aspirin, indomethacin and phenylbutazone). 3. Arthritic patients may be more susceptible to the ulcerogenic actions of NSAI drugs. Experiments with animals, together with evidence from clinical studies, indicate that stress factors and the presence of decreased mucosal resistance in the diseased state may contribute to the enhanced susceptibility of the GI tract towards the ulcerogenicity of NSAI drugs. 4. Comparison of data on gastroscopic observations in man with the author's data on the effects of NSAI drugs in stress-sensitized rats shows the latter technique appears to be a useful means of predicting the ulcerogenic potential of NSAI drugs in man. The comparison has also been used to predict the ulcerogenicity of drug - alcohol combinations; alcohol being a common ulcerogen consumed by many patients. Some NSAI drugs with low ulcerogenic activity (i.e. azapropazone, benoxaprofen and fenclofenac) in the stressed-rat assay show little or no interaction with alcohol. These studies using laboratory animals show the importance of employing conditions to mimic environmental factors (e.g. stress and alcohol consumption) which might predispose individuals to ulcerogenic or other side-effects of NSAI drugs. From these studies it appears possible to construct 'predictive profiles' of the relative ulcerogenicity of NSAI drugs which may be applicable to the clinical situation in man.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Rainsford KDdoi
10.1007/BF00541263subject
Has Abstractpub_date
1982-01-01 00:00:00pages
1-10issue
1eissn
0172-8172issn
1437-160Xjournal_volume
2pub_type
杂志文章abstract::Ankylosing spondylitis is a rather uncommon condition in the UAE. Over a period of 10 years. 28 hospital-based patients diagnosed as having AS were retrospectively studied. They included 17 Arabs and 11 Asians. The onset of AS in most patients in this study was in adulthood (mean age at onset was 27.7 years in Arabs a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960050033
更新日期:1998-01-01 00:00:00
abstract::Previous studies showed a link between systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection. We sought to determine the features of serologic response to EBV in SLE patients and whether this response differs from those of systemic sclerosis (SSc) and primary antiphospholipid syndrome (PAPS) patien...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1573-4
更新日期:2012-01-01 00:00:00
abstract::PXK was identified as a novel candidate gene for systemic lupus erythematosus (SLE) from genome-wide association studies (GWAS) in Caucasians. But a recent replication study in Hong Kong Chinese reported that PXK was not associated with SLE. The aim of this study was to determine whether PXK is associated with SLE in ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1789-3
更新日期:2012-01-01 00:00:00
abstract::The diagnosis of Kawasaki disease (KD), a common pediatric vasculitis, is based solely on clinical criteria. There is a need for a robust laboratory marker that can help differentiate KD from other acute, febrile, childhood illnesses and also to predict cardiac involvement. We conducted a cross-sectional study of 25 c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3430-6
更新日期:2016-04-01 00:00:00
abstract::The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an excessive regional inflammation, sensitization of primary somatosensory afferents, and sensitization of spinal neurons are considered to have a role in the pathogenesis of RSD. The underlying pathophysiology relating the c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0009-z
更新日期:2006-03-01 00:00:00
abstract::Takayasu's arteritis (TA) is a rare chronic vasculitis of the aorta and its main branches. Infectious agents or autoimmunity are thought to influence the pathophysiology. Ethnic preponderance in East Asia and usually affects young Asian women suggesting a possible role of genetic factor in the etiology. We present a r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1234-7
更新日期:2011-06-01 00:00:00
abstract::Interleukin-15 (IL-15) is a pleotrophic cytokine that is involved in the pathogenesis of diverse inflammatory rheumatic diseases. The aims of this study were to compare serum IL-15 levels and expression of its receptor (IL-15Rα) in Behçet's disease (BD) with those in other rheumatic diseases and to identify the relati...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2705-4
更新日期:2013-08-01 00:00:00
abstract::Macrophagic myofascitis (MMF) is an unusual inflammatory myopathy characterized by muscle infiltration by macrophages and lymphocytes. Here, we describe a case of MMF which is associated with rheumatoid arthritis. A 53-year-old Japanese rheumatoid arthritis (RA) patient presented with focal tenderness of lower extremi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1015-3
更新日期:2010-05-01 00:00:00
abstract::Nailfold videocapillaroscopy was performed in 21 controls (C) and 21 patients (P) with systemic lupus erythematosus (SLE) classified according to the American College of Rheumatology, with, at least, 1 year of diagnosed disease and having low activity (MEX-SLEDAI) and sequel (SLICC) indexes at the time of the examinat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0033-z
更新日期:2006-05-01 00:00:00
abstract::Thrombocytosis is well described in children with Kawasaki disease (KD). We describe six children with KD who had thrombocytopenia at disease onset. This is an unusual finding and has clinical implications in the diagnosis of this condition. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0947-y
更新日期:2009-12-01 00:00:00
abstract::The aim of the present study was to evaluate the effect of long-term leflunomide and methotrexate (MTX) therapy during the course of rheumatoid arthritis (RA) estimated by digital X-ray radiogrammetry (DXR) and computer-aided joint space analysis (CAJSA) as diagnostic tools for the quantification of disease-related pe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0682-9
更新日期:2009-01-01 00:00:00
abstract::The aim of the study was to assess agreement between three-dimensional volumetric ultrasound (3D US) performed by inexperienced staff and real-time conventional ultrasound (2D US) performed by experienced rheumatologists in detecting and scoring rheumatoid arthritis (RA) lesions. Thirty-one RA patients underwent exami...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3606-0
更新日期:2017-02-01 00:00:00
abstract::Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1374-9
更新日期:2011-06-01 00:00:00
abstract::Spondyloarthropathy refers to any joint disease of the vertebral column, but the term is mainly used for a specific group of disorders called seronegative spondyloarthropathies (SpAs). The axial skeletal involvement, peripheral and extra-articular manifestations and an association with the major histocompatibility com...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04346-0
更新日期:2019-09-01 00:00:00
abstract::Aseptic loosening is the predominant cause of total hip implant failure. It has been assumed that a layer or membrane, containing macrophages, fibroblasts and vascular endothelial cells, of synovial-like tissue develops at the implant-to-bone interface almost invariably and, with time, somehow leads to loosening of th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960050037
更新日期:1998-01-01 00:00:00
abstract::Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in wome...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04591-8
更新日期:2020-09-01 00:00:00
abstract::Life expectancy in autoimmune rheumatic diseases (ARDs) remains lower compared to the general population, due to various comoborbidities. Cardiovascular disease (CVD) represents the main contributor to premature mortality. Conventional and biologic disease-modifying antirheumatic drugs (DMARDs) have considerably impro...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4004-6
更新日期:2018-06-01 00:00:00
abstract::The aim of the study is to study the relationship between androgen levels and bone mineral density (BMD) in elderly Arab males. Forty-five elderly Arab males underwent Dual X-ray absorptiometry for measurement of BMD. The outcomes were defined as per WHO description. Assays for testosterone (T), gonadotropins (LH and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0970-z
更新日期:2010-01-01 00:00:00
abstract::Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0638-0
更新日期:2008-11-01 00:00:00
abstract::The aim of this study was to investigate the association of three polymorphisms of CD154 with risk of SLE in Chinese population. The study population comprised 770 Chinese individuals, including 350 SLE patients and 420 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3745-y
更新日期:2017-08-01 00:00:00
abstract::The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease seve...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541162
更新日期:1982-01-01 00:00:00
abstract::Familial Mediterranean fever is characterized by self-limited attacks of serositis and arthritis. However, substantial number of patients suffer from chronic complications of this disease, primarily involving musculoskeletal system. Treatment for these complications is challenging due to limited evidence. Interleukin-...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04490-7
更新日期:2020-01-01 00:00:00
abstract::Sixty-six hospitalized patients with systemic lupus erythematosus (SLE) were enrolled into this study. The test for anti-mitochondrial antibodies (AMAs) was performed and biochemical parameters were determined. AMAs were detected in 15 of the 66 patients with SLE. Meanwhile, we compared enzymatic levels in AMA-positiv...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0034-y
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:The prevalence of dermatophytic infections in rheumatoid arthritis is unknown. This study investigated the prevalence of dermatophytosis in patients with rheumatoid arthritis and the relationship between sulfasalazine, low-dose methotrexate and steroid therapy. METHODS:We examined 53 consecutive patients wit...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0238-3
更新日期:2003-01-01 00:00:00
abstract::We report a case of an association of four autoimmune diseases in a 15-year-old girl and we discuss the etiopathogenic of this association and difficulties of treatment. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0988-2
更新日期:2010-04-01 00:00:00
abstract::We report our experience and hypothesis on the diagnosis and treatment of patients with vasculitis who are simultaneously diagnosed with serum-positive cytomegalovirus (CMV) immunoglobulin (Ig)M antibodies and negative CMV DNA polymerase chain reaction (PCR). It remains unknown how to treat this kind of "phantom" CMV ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0522-5
更新日期:2005-10-01 00:00:00
abstract::There are contradictory results in the relevant literature about the relationship between objective determinants of craniocervical posture and temporomandibular disorder (TMD), whereas no study has worked on ankylosing spondylitis (AS) and TMD relationship. We conducted this study to test the predictors of TMD in AS p...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04563-y
更新日期:2020-06-01 00:00:00
abstract::In Spain, the QUANTUM project has been promoted to reduce variability in clinical practice and improve the care and quality of life of people with psoriatic arthritis (PsA) by accrediting PsA units throughout the Spanish national health system. To present the results of this approach which sought to ensure an optimum ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04632-2
更新日期:2020-11-01 00:00:00
abstract::Primary osteoarthritis (OA) is a multifactorial disease with several genetics factors involved. The COL2A1 gene is of particular interest because it encodes for the most abundant protein in articular cartilage. The aim was to evaluate the association of COL2A1 gene polymorphism with OA of the knee in Mexican Mestizo p...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1091-4
更新日期:2010-06-01 00:00:00
abstract::The objective of this study was to determine whether levels of soluble receptors for tumor necrosis factor type I and type II (sTNF-RI and sTNF-RII) as measured in paired synovial fluids (SF) of arthritis patients are associated with clinical or laboratory parameters of local inflammation. sTNF-RI and -RII were measur...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00290299
更新日期:1993-01-01 00:00:00