Abstract：
:Protein synthesis in all cells is readily interrupted by environmental stresses such as hyperthermia. However, stressed cells also have mechanisms which, even under conditions where normal protein synthesis is completely inhibited, allow them to synthesise a group of highly conserved proteins--the so-called heat shock proteins (HSP). Some of these proteins are now known to facilitate the recovery of normal RNA processing and protein synthesis after exposure to hyperthermia and to protect the cell against further damage. They also play an important role in the synthesis and transport of normal proteins in unstressed cells, and perhaps also the export from cells of abnormal proteins of host or viral origin. Synthesis of HSP is also triggered by exposure to stresses other than hyperthermia, for example heavy metals (e.g. gold complexes), thiol-reactive chemicals, near UV radiation, viruses, oxyradicals and certain cytokines. Furthermore, there are also a number of proteins which are induced by these physicochemical stresses but not by heat; for this reason "stress protein" will be used as a general term to describe both HSP and related, physicochemically-induced, proteins. The cysteine-rich metallothioneins, which behave in some respects as stress proteins, will not be included in this review. Because many of the factors which stimulate stress protein induction occur during inflammatory and immune responses, there has been increasing interest in the possible role of stress proteins in inflammatory disease such as arthritis. The purpose of this article is to review the basic biochemical mechanisms involved in the induction of stress proteins and offer some speculations on their potential role in rheumatic disease.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Hurst NPdoi
10.1007/BF00541323subject
Has Abstractpub_date
1990-01-01 00:00:00pages
271-6issue
6eissn
0172-8172issn
1437-160Xjournal_volume
9pub_type
杂志文章,评审abstract：:The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the ne...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1672-2
更新日期：2011-08-01 00:00:00
abstract：:The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-3964-x
更新日期：2018-04-01 00:00:00
abstract：:Several studies of rheumatoid arthritis (RA) incidence and prevalence indicate that occurrence of the disease varies significantly among different populations. We aimed to estimate the prevalence and incidence of RA in South Korea. We used Korean National Health Insurance (NHI) claims data to estimate the prevalence o...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2590-2
更新日期：2013-06-01 00:00:00
abstract：:The aim of this study was to compare clinical symptoms, perceived health status, health resource use and psychosocial features in fibromyalgia (FM) patients at different health care levels. A total of 315 participants were recruited from primary care (PC) (n=101) and rheumatology settings (RS) (n=214). Subjects comple...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0818-y
更新日期：2009-08-01 00:00:00
abstract：:Macrophage activation syndrome (MAS) is a clinical syndrome caused by an excessive proliferation of T lymphocytes and well-differentiated macrophages; an entity distinct from malignant histiocytosis. Although rheumatologic conditions are the common cause of MAS, a wide range of infections are also seen to cause MAS. W...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1033-1
更新日期：2010-06-01 00:00:00
abstract：:Juvenile dermatomyositis (JDM) is a rare but complex and potentially life-threatening autoimmune disease of childhood. Significant proportions of patients have residual weakness, muscle atrophy, joint contractures, and calcinosis. Recently, new clinical findings, such as lipodystrophy accompanied with increased fat de...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3031-1
更新日期：2014-11-01 00:00:00
abstract：:A 7-year-old child was first admitted for persistent fever of 15-day duration and suspected meningitis. Kawasaki syndrome was lately diagnosed upon the recognition of an extensive diffuse coronary artery damage characterized by medium-sized aneurysms of the epicardial vessels. An eccentric thrombus along the inferior ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-1814-1
更新日期：2012-03-01 00:00:00
abstract：:The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observationa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3814-2
更新日期：2017-11-01 00:00:00
abstract：:To evaluate the correlation between measurements of antinuclear antibodies serum levels by enzyme immunoassay (ANA-EIA), and the degree of systemic lupus erythematosus disease activity. To retest the performance of the test compared to measurement of antinuclear antibodies by immunofluorescence (ANA-IIF). Eighty-five ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0324-7
更新日期：2007-08-01 00:00:00
abstract：:In December 2019, numerous coronavirus disease 2019 (COVID-19) cases were reported in Wuhan, China, which has since spread throughout the world. However, its impact on rheumatoid arthritis (RA) patients is unknown. Herein, we report a case of COVID-19 pneumonia in a 61-year-old female RA patient who was receiving conv...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04584-7
更新日期：2020-06-01 00:00:00
abstract：:The aim of this study was to investigate (a) the mortality in a clinical cohort of patients with established rheumatoid arthritis in comparison with the general Dutch population over 15 years, (b) the trend in the mortality ratio during the study period, and (c) causes of death and compare these with the general popul...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3638-5
更新日期：2017-04-01 00:00:00
abstract：:The objective of the study was to evaluate synovial tissue receptor activator of nuclear factor-κβ ligand (RANKL) and osteoprotegerin (OPG) as biomarkers of disease activity, progressive joint damage, and therapeutic response, during cytokine blockade in rheumatoid arthritis (RA). Patients with active RA entered a ran...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-009-1191-1
更新日期：2010-11-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disorder leading to disability and reduced quality of life. Effective treatment with biologic DMARDs poses a significant economic burden. The Abatacept versus Adalimumab Comparison in Biologic-Naïve RA Subjects with Background Methotrexate (AMPLE) trial was a head-to...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00296-017-3739-9
更新日期：2017-07-01 00:00:00
abstract：:Regional migratory osteoporosis (RMO) is an idiopathic disorder characterized by severe periarticular pain, transient and migratory arthralgia, and osteoporosis. Osteoporosis in this disease may appear in the form of local regional osteoporosis and bone marrow edema or generalized osteoporosis. It occurs most commonly...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1256-1
更新日期：2011-10-01 00:00:00
abstract：:The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1176-0
更新日期：2010-09-01 00:00:00
abstract：:Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease but it has been found in many other autoimmune diseases like systemic lupus erythematosus (SLE). Furthermore, cross-reactive epitopes on β2-glycoprotein I (β2GPI) and Saccharomyces cerevisiae were found in SLE patients. T...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2431-3
更新日期：2013-03-01 00:00:00
abstract：:Ultrasonography (US) and power Doppler sonography (PDS) was used to investigate causes of new onset of shoulder pain and sites of shoulder inflammation in 157 shoulders of 99 patients with rheumatoid arthritis (RA). US detected effusion and/or synovitis in 92/157 glenohumeral joints, subdeltoid bursitis in 56/157 shou...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0465-8
更新日期：2008-03-01 00:00:00
abstract：:Osteomyelitis variolosa is an osteoarticular complication of small pox infection. We are presenting a case of osteomyelitis variolosa, who presented to us with fracture of ankle on the involved side with other orthopedic sequelae of small pox infection, which he contracted during his childhood period. We have discusse...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2194-2
更新日期：2012-11-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is a rare disease, and large epidemiological studies of this disease are limited. Furthermore, it has been difficult to show the incidence and characteristics of severe AOSD complications due to the rarity of this disease. The aim of our study was to describe the demographics of AOSD...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3546-8
更新日期：2016-10-01 00:00:00
abstract：:The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-3980-x
更新日期：2018-04-01 00:00:00
abstract：:We have investigated the role of the Th17-related cytokines interleukin-17A (IL-17A), IL-21, and IL-23 in spondyloarthritis (SpA) by examining their association with disease activity and magnetic resonance imaging (MRI) findings in patients with SpA (n = 80). Furthermore, to investigate the cellular origins of the cyt...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1655-3
更新日期：2012-02-01 00:00:00
abstract：:Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (tota...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0502-9
更新日期：2005-05-01 00:00:00
abstract：:A 44-year-old man with intermittent asymmetric migratory oligoarthritis lasting the recent decade was admitted to our hospital. Considerable specific biomarkers for rheumatoid arthritis such as anti-agalactosyl IgG antibody are all negative. He was diagnosed as palindromic rheumatism (PR). Although hand X-rays showed ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0654-0
更新日期：2008-11-01 00:00:00
abstract：:Fibromyalgia (FM) is the most common chronic pain syndrome encountered in medical practice, affecting females more than males, and the estimated prevalence of FM in Egypt is 1.3 %. The aim was to translate and adapt the Fibromyalgia Impact Questionnaire (FIQ) into Arabic and assess reliability and validity. The Arabic...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2779-z
更新日期：2013-10-01 00:00:00
abstract：:Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3385-z
更新日期：2016-03-01 00:00:00
abstract：:Macrophagic myofascitis (MMF) is an unusual inflammatory myopathy characterized by muscle infiltration by macrophages and lymphocytes. Here, we describe a case of MMF which is associated with rheumatoid arthritis. A 53-year-old Japanese rheumatoid arthritis (RA) patient presented with focal tenderness of lower extremi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1015-3
更新日期：2010-05-01 00:00:00
abstract：:We aimed to investigate how orbital blood flow rates in patients with rheumatoid arthritis (RA) are affected by the active and remission phase of the disease. This prospective study included a total of 56 patients with RA (study group) and 24 control individuals (control group). All RA patients were divided into two g...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04275-y
更新日期：2019-06-01 00:00:00
abstract：:Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541352
更新日期：1985-01-01 00:00:00
abstract：:Alkoptunuria is an inherited autosomal recessive metabolic disorder which is caused by the lack of homogentisic acid-oxidase enzyme. It is associated with various systemic abnormalities and related to the deposition of homogentisic acid pigment in connective tissues. These pigmentary changes are termed "ochronosis". W...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0538-x
更新日期：2005-08-01 00:00:00
abstract：:We report a 53-year-old Turkish female presented with progressive weakness and mild dyspnea. Laboratory results demonstrated severe hypokalemia with hyperchloremic metabolic acidosis. The urinary anion gap was positive in the presence of acidemia, thus she was diagnosed with hypokalemic paralysis from a severe distal ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2322-z
更新日期：2013-07-01 00:00:00
