Hypokalemic periodic paralysis in Sjogren's syndrome secondary to distal renal tubular acidosis.

Abstract:

:We report a 53-year-old Turkish female presented with progressive weakness and mild dyspnea. Laboratory results demonstrated severe hypokalemia with hyperchloremic metabolic acidosis. The urinary anion gap was positive in the presence of acidemia, thus she was diagnosed with hypokalemic paralysis from a severe distal renal tubular acidosis (RTA). Immunologic work-up showed a strongly positive ANA of 1:3,200 and positive antibodies to SSA and SSB. Schirmer's test was abnormal. Autoimmune and other tests revealed Sjögren syndrome as the underlying cause of the distal renal tubular acidosis. Renal involvement in Sjogren's syndrome (SS) is not uncommon and may precede sicca complaints. The pathology in most cases is a tubulointerstitial nephritis causing among other things, distal RTA, and, rarely, hypokalemic paralysis. Treatment consists of potassium repletion, alkali therapy, and corticosteroids. Primary SS could be a differential in women with acute weakness and hypokalemia.

journal_name

Rheumatol Int

authors

Yılmaz H,Kaya M,Özbek M,ÜUreten K,Safa Yıldırım İ

doi

10.1007/s00296-011-2322-z

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

1879-82

issue

7

eissn

0172-8172

issn

1437-160X

journal_volume

33

pub_type

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