Abstract：
:Non-tuberculous mycobacteria (NTM) are an unusual cause of osteomyelitis in immunocompetent children. Diagnosis is often difficult due to the paucity of clinical symptoms and a subtle course of the disease. NTM comprise a group of about 91 identified species of environmental mycobacteria that cause infections most frequently in immunocompromised individuals or in patients with predisposing factors. Cervical lymphadenitis is the most common presentation of NTM infection in children. Invasive and recurrent infections with these organisms have been associated with a genetic defect of the interferon gamma-receptor. We report a 3-year-old immunocompetent girl who presented a NTM osteomyelitis of the left femur. Four months before she had been treated with medical and surgical therapy for a mycobacterium avium complex cervical lymphadenitis. Polymerase chain reaction assay on bone aspirate specimens confirmed the diagnosis of mycobacterium avium osteomyelitis. The patient was treated successfully with clarithromycin and rifampicin for 6 months.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Breda L,de Michele G,Nozzi M,De Sanctis S,Di Marzio D,Chiarelli Fdoi
10.1007/s00296-009-0844-4subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1487-9issue
12eissn
0172-8172issn
1437-160Xjournal_volume
29pub_type
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