Abstract：
OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age at onset of disease, and a history of vertebral fracture was inserted in one issue of the membership journals of the AS patient organizations in Germany and Austria. RESULTS:Among the 1,071 patients responding who all had indicated that the diagnosis of AS had been established or confirmed by a physician, 61 (5.7%) indicated a history of vertebral fracture, 15 of them (1.4%) without an accident. The prevalence of vertebral fractures was 6.2% among male AS patients and 4.6% among females (NS), and 4.8% among HLA-B27+ patients and 9.9% among HLA-B27(-) patients (p<0.05). Spinal fractures occurred more often among AS patients with peripheral arthritis (7.1%) than among patients with axial involvement only (3.1%, p<0.01). The average delay between disease onset and diagnosis of AS was 10.5 years for patients with a vertebral fracture, compared to 8.7 years for patients without any such event (p<0.05). Among patients with a disease duration >or=42 years, the prevalence of vertebral fractures was 14%. The annual incidence of vertebral fractures which occurred without an accident had a maximum of 0.1% per annum at a disease duration of 20-35 years, whereas the incidence of vertebral fractures caused by an accident increased continuously with increasing disease duration, amounting to 1.3% per annum after a disease duration of 45 years. CONCLUSION:A considerable proportion of AS patients will experience a vertebral fracture during the course of the disease, in particular if peripheral joints are also involved.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Feldtkeller E,Vosse D,Geusens P,van der Linden Sdoi
10.1007/s00296-004-0556-8subject
Has Abstractpub_date
2006-01-01 00:00:00pages
234-9issue
3eissn
0172-8172issn
1437-160Xjournal_volume
26pub_type
杂志文章abstract：:To determine the "hand anatomic index" (HAI--a quantitative measure of hand deformity) in systemic sclerosis (scleroderma) and to compare it with the other measures of hand deformity and functional impairment. The HAI (measure of open hand span minus closed hand span/lateral height of hand) was determined in 30 patien...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0058-3
更新日期：2006-03-01 00:00:00
abstract：:The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen ind...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274777
更新日期：1990-01-01 00:00:00
abstract：:Increased QT interval dispersion has been associated with an increased risk for ventricular arrhythmias and sudden cardiac events. We examined the QT interval dispersion in 20 North Indian children with Kawasaki disease (KD) with no coronary artery abnormalities on echocardiography compared the same with matched contr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1252-5
更新日期：2011-03-01 00:00:00
abstract：:Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2340-x
更新日期：2013-01-01 00:00:00
abstract：:The objective of this study was to search for proteomic patterns distinguishing patients with rheumatoid arthritis (RA) from healthy controls, biomarker candidates specific for early RA, and proteins reflecting disease activity, by profiling of serum proteins using magnetic bead-based (MB) separation and matrix-assist...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1407-4
更新日期：2011-08-01 00:00:00
abstract：:The presence of specific anti-Proteus antibodies in active, rheumatoid arthritis (RA) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, ELISA, Western blotting and immunofluorescence. Furthermore, anti-HLA-DR4 tissue typing sera have been shown to bind to Proteus microorga...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/BF00271885
更新日期：1989-01-01 00:00:00
abstract：:Schistosomiasis or bilharzia is a parasitic disease found in tropical countries. Most infections are subclinical but may progress to chronic form characterized most frequently by the presence of liver involvement and portal hypertension. We report a patient that presented chronic polyarthritis with positive rheumatoid...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1562-7
更新日期：2013-05-01 00:00:00
abstract：:Acromegaly is a chronic endocrinopathy characterized by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-1 (IGF-1). The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. Rheumatoid arthritis (RA) is a rarely repo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1490-6
更新日期：2012-09-01 00:00:00
abstract：:An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3774-6
更新日期：2017-10-01 00:00:00
abstract：:Using a sensitive and specific enzyme-linked immunosorbent assay (ELISA) assay we showed that the cryoglobulins of a patient with Lucio phenomenon contain phenolic glycolipid I antigen and a specific antibody. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541512
更新日期：1986-01-01 00:00:00
abstract：:Neuropathic arthropathy (NA), known as Charcot neuroarthropathy, is a chronic, degenerative arthropathy and is associated with decreased sensory innervation. Numerous causes of this arthropathy have been described. Neuropathic joint, although first described by Charcot in tabes dorsalis in 1868, has subsequently been ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1013-5
更新日期：2010-05-01 00:00:00
abstract：:Arachnoid ossificans is a rare type of chronic arachnoiditis characterised by the presence of calcification or ossification of the dura and arachnoid. There are a few reports of these findings in relation to various disease entities, but only one case has been reported in relation to ankylosing spondylitis. We describ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2293-0
更新日期：2013-06-01 00:00:00
abstract：:The cost-effectiveness of treatments that have the potential to change the "natural history" of a chronic progressive disease has to be evaluated over the long term. Cost-effectiveness estimates have been based on the concept that, with treatment, patients will not progress to the next level(s) of disease severity or ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1502-6
更新日期：2011-11-01 00:00:00
abstract：:One hundred and eighteen unrelated Greek patients with classic rheumatoid arthritis (RA) were tissue-typed for HLA-A, -B, -DR antigens and the frequency was compared to that of healthy controls. Greek RA patients regardless of sex, anatomical severity, seropositivity and age at disease onset are not associated with an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541336
更新日期：1985-01-01 00:00:00
abstract：:A 56-year-old woman presented with changes characteristic of the reflex sympathetic dystrophy syndrome (RSDS) but also frank synovitis of the left wrist, an elevated ESR and early damage of the left carpus on radiographs, suggesting septic arthritis. A dynamic scan showed changes characteristic of RSDS. A sample of sy...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541334
更新日期：1985-01-01 00:00:00
abstract：:This study examines whether or not MBD4 polymorphism is a marker for rheumatoid arthritis (RA) susceptibility or severity for Chinese patients in Taiwan. This study included 193 patients with RA, while 190 unrelated healthy individuals living in Central Taiwan served as controls. The relationship between MBD4 polymorp...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1545-8
更新日期：2012-01-01 00:00:00
abstract：:The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0461-z
更新日期：2008-03-01 00:00:00
abstract：:Although subclinical liver disease is common in systemic lupus erythematosus (SLE), strikingly high levels of liver enzymes are rare. Our aim was to determine the cause of high levels of liver enzymes in lupus patients, particularly in patients diagnosed with toxic hepatitis. We performed a retrospective chart review ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1237-4
更新日期：2011-01-01 00:00:00
abstract：:Malignant neoplasms are associated with a wide variety of paraneoplastic rheumatological syndromes. The paraneoplastic nature should be based on specific criteria. We report a series of eight cases of paraneoplastic rheumatic syndromes revealing an underlying neoplasia. Our series consists of six men and two women, wi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2252-9
更新日期：2012-06-01 00:00:00
abstract：:Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541153
更新日期：1981-01-01 00:00:00
abstract：:Uveitis in juvenile idiopathic arthritis (JIA) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first-choice therapy, and immunosuppression is commonly used. However, treatment has not been standardized. Representatives from the German Ophthalmological Soc...
journal_title：Rheumatology international
pub_type： 杂志文章,实务指引,评审
doi：10.1007/s00296-011-2126-1
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:Examine the association between physical activity and sedentary time with high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. We also investigated the dose of physical activity that was associated with lower clinical levels of high sensitivity C-Reactive protein (< 3 mg/L). MA...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04571-y
更新日期：2020-09-01 00:00:00
abstract：:The purpose of this study was to demonstrate the direct effects of celecoxib, one of the selective cyclo-oxygenase (COX)-2 inhibitors, on nitric oxide (NO) and prostaglandinE2 (PGE2) synthesis in cultured osteoarthritic chondrocyte comparing with those of indomethacin. Articular chondrocytes were isolated from rat ost...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0107-6
更新日期：2006-09-01 00:00:00
abstract：:In a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4044-y
更新日期：2018-08-01 00:00:00
abstract：:To evaluate the correlation between measurements of antinuclear antibodies serum levels by enzyme immunoassay (ANA-EIA), and the degree of systemic lupus erythematosus disease activity. To retest the performance of the test compared to measurement of antinuclear antibodies by immunofluorescence (ANA-IIF). Eighty-five ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0324-7
更新日期：2007-08-01 00:00:00
abstract：:The objective of this study was to analyze the clinical characteristics, associated disorders, and the most common sites of stress fractures in rheumatological patients. Over a 3-year period, 35 patients with 44 stress fractures were prospectively recruited from an outpatient rheumatological department (32 postmenopau...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0194-y
更新日期：2002-06-01 00:00:00
abstract：:Low-dose radiotherapy (LD-RT) has been widely used for treatment of non-malignant disorders since its introduction and animal studies show anti-inflammatory effects in osteoarthritis (OA). However, the evidence for its effect in clinical practice remains unclear. Therefore, the aim of this study is to systematically s...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3337-7
更新日期：2016-01-01 00:00:00
abstract：:Patients with rheumatoid arthritis (RA) are at increased risk of low bone density and fractures. This study identifies predictors of initiation of dual energy X-ray absorptiometry (DXA) testing in RA. We identified RA patients from the CORRONA registry with >or=1 year follow-up without reported DXA at study entry. The...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0804-4
更新日期：2009-06-01 00:00:00
abstract：:Therapeutics targeting sphingosine-1-phosphate (S1P), a kind of lipid mediator regulating immune cell trafficking, has been emerging rapidly as a novel line of regimen for autoimmune diseases, including rheumatoid arthritis (RA). Here, we propose that S1P-targeted therapy is beneficial not only for limiting inflammati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1634-8
更新日期：2011-07-01 00:00:00
abstract：:To investigate the clinical manifestations and outcomes of musculoskeletal (MSK) nontuberculous mycobacterium (NTM) infections. This study was a retrospective cohort study using the Siriraj Hospital database from 2005 to 2017. Enrolled were all patients aged 15 or older who had an MSK infection with NTM identified in ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04392-8
更新日期：2019-10-01 00:00:00
