Abstract：
:Although subclinical liver disease is common in systemic lupus erythematosus (SLE), strikingly high levels of liver enzymes are rare. Our aim was to determine the cause of high levels of liver enzymes in lupus patients, particularly in patients diagnosed with toxic hepatitis. We performed a retrospective chart review of SLE patients treated at the Inje University Hospital between 2001 and 2008. We defined liver enzyme abnormality as a twofold or greater increase in two or more of the following four components: total bilirubin, AST, ALT and LDH or ALP. Acute toxic hepatitis was diagnosed by a score ≥ 5 in the Roussel Uclaf Causality Assessment Method. Of 141 SLE patients 46 (32.6%) met strict criteria for the liver enzyme abnormality. In total, 11 patients (7.8%) in this study had presumed toxic hepatitis associated with either herbal medicines (n = 6), anti-tuberculosis medications (n = 3), antibiotics (n = 1) or valproic acid (n = 1). There were striking laboratory abnormalities in the groups diagnosed with toxic hepatitis (mean peak values: AST 775 ± 464 U/L, ALT 400 ± 447 U/L, ALP 767 ± 408 U/L, LDH 1,469 ± 779 U/L). All six patients with herbal-induced toxic hepatitis were in the active SLE state. After cessation of the suspected causative medication and subsequent administration of steroids, liver enzyme levels were improved. Herbal medicines and anti-tuberculosis medications, known to cause toxic hepatitis, can also induce increased liver enzyme levels in lupus patients. However, since most herbal medicines contain a mixture of various products, we could not ascertain what specific ingredient induced the increase in liver enzyme levels.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Her M,Lee Y,Jung E,Kim T,Kim Ddoi
10.1007/s00296-009-1237-4subject
Has Abstractpub_date
2011-01-01 00:00:00pages
79-84issue
1eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
杂志文章abstract：:To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2282-3
更新日期：2012-12-01 00:00:00
abstract：:The mechanisms of male idiopathic osteoporosis are little known. We evaluated bone mineral loss by dual-energy X-ray absorptiometry and determined its cortical or trabecular nature in a cohort of men with idiopathic osteoporosis with fractures. Thirty-nine men (mean age 60 ± 13 years), with negative investigations for...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2076-7
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:The prevalence of dermatophytic infections in rheumatoid arthritis is unknown. This study investigated the prevalence of dermatophytosis in patients with rheumatoid arthritis and the relationship between sulfasalazine, low-dose methotrexate and steroid therapy. METHODS:We examined 53 consecutive patients wit...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0238-3
更新日期：2003-01-01 00:00:00
abstract：:Macrophage activation syndrome (MAS) is a hyper-inflammatory disorder secondary to a rheumatic disease such as systemic juvenile idiopathic arthritis (SJIA) and systemic lupus erythematosus (SLE). We aimed to present the characteristics of our pediatric MAS patients. Clinical features, laboratory parameters, treatment...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3545-9
更新日期：2016-10-01 00:00:00
abstract：:We report a case of sudden onset of late infection after TKA inflamed by anti-TNFalpha therapy, Infliximab, in a 54-year-old woman with RA. Infliximab therapy was started 3 years and 8 months after TKAs as a result of multiple arthritides showing high inflammation of RA. One week after the third administration of Infl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0948-x
更新日期：2010-01-01 00:00:00
abstract：:The objective of this study was to translate and evaluate the psychometric properties of the Thai version of the Rheumatoid Arthritis Disease Activity Index (RADAI) in patients with rheumatoid arthritis (RA). We translated and modified the original RADAI into the Thai version. A total of 116 Thai patients with RA were...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2749-5
更新日期：2013-10-01 00:00:00
abstract：:Secondary amyloidosis is a well-known complication of certain familial Mediterranean fever (FMF). We presented three Turkish patients with FMF and biopsy proven amyloidosis. These patients were treated with colchicine 1.5 mg/day. They have experienced five to six peritonitis attacks with fever within 1 year. On admiss...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0188-2
更新日期：2006-12-01 00:00:00
abstract：:HLA-DR antigens were determined in 111 patients with classic or definite rheumatoid arthritis. HLA-DR4 was significantly (P corr. less than 10(-6] increased in patients with rheumatoid arthritis (54%) compared with controls (23.2%). HLA-DR 5 was decreased in rheumatoid arthritis (12.6% vs 26.4% of controls); however, ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541190
更新日期：1983-01-01 00:00:00
abstract：:We report on a 7-month-old infant with Kawasaki disease (KD) whose only manifestations were high-grade fever of 7 days duration, "non-toxic look" and "extreme irritability", thereby not meeting the criteria for the classical or the atypical form of the disease. The diagnosis was confirmed by the demonstration of a sol...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0899-2
更新日期：2009-07-01 00:00:00
abstract：:This retrospective medical chart review aimed to provide a current, real-world overview of biologic usage in patients with rheumatoid arthritis (RA) in Germany, Spain, and the UK, and estimate clinical and healthcare utilization outcomes associated with early versus late treatment. Adults (≥18 years) with a confirmed ...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-015-3312-3
更新日期：2015-11-01 00:00:00
abstract：:We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000054
更新日期：2000-01-01 00:00:00
abstract：:We present the case of a patient with long-standing rheumatoid arthritis and an acute onset of total dysfunction of the posterior tibial tendon. On MRI, a rupture of the tendon was apparent. Intraoperatively, however, massive tenosynovitis with stricture of the tendon was identified as the cause of posterior tibial te...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0183-1
更新日期：2002-05-01 00:00:00
abstract：:Tumor necrosis factor (TNF) antagonists are among the most effective therapies for rheumatoid arthritis (RA), yet not all patients show a response. Using meta-analysis, this present study was designed to investigate whether or not the TNF-alpha promoter -308 A/G polymorphism is associated with responsiveness to anti-T...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-006-0175-7
更新日期：2006-12-01 00:00:00
abstract：:Kawasaki disease (KD) is a systemic vasculitis that can involve the nervous system, including the cranial nerves. Central nervous system findings, especially irritability, lethargy, and aseptic meningitis, occur in 1-30 % of KD patients (1). Cranial nerve palsies are seen rarely, and abducens nerve palsy has been repo...
journal_title：Rheumatology international
pub_type： 信件
doi：10.1007/s00296-016-3515-2
更新日期：2016-08-01 00:00:00
abstract：:Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3385-z
更新日期：2016-03-01 00:00:00
abstract：:Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04689-z
更新日期：2021-02-01 00:00:00
abstract：:TNF-α is one of the key proinflammatory cytokines in pathogenesis of rheumatoid arthritis (RA). TNF-α was also found to enhance synthesis of leptin. Leptin is mainly adipocyte-derived hormone controlling appetite and energy expenditure. It acts through inhibition of neuropeptide Y secretion. It is possible that TNF-α-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2182-6
更新日期：2012-11-01 00:00:00
abstract：:Intercellular adhesion molecule-1 (ICAM-1) is a membrane-bound molecule primarily involved in cell-cell adhesive interactions of the immune system. It is a cytokine-induced glycoprotein involved in the recruitment of cells into tissues undergoing inflammatory responses. The levels of soluble ICAM-1 were measured in se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-001-0159-6
更新日期：2002-01-01 00:00:00
abstract：:31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00291145
更新日期：1991-01-01 00:00:00
abstract：:To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological gui...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3201-1
更新日期：2015-06-01 00:00:00
abstract：:There are numerous causes of pulmonary cavitary lesions as infection (bacterial, parasitic and invasive fungal), Wegener granulomatosis (WG) and other vasculitis, sarcoidosis, malignancy, septic thromboembolism, airways disease (cystic bronchiectasis and bullae), pneumatoceles and traumatic parenchymal laceration. Her...
journal_title：Rheumatology international
pub_type： 信件
doi：10.1007/s00296-012-2424-2
更新日期：2013-08-01 00:00:00
abstract：:Rheumatology has its roots in ancient Greece. Hippocrates and other prominent Greek (Hellenes) physicians in ancient times, Hellenistic, Roman, and Byzantine period were acute observers of disease course and of patients and were able to define many disorders. They wrote books on various aspects of medicine and these w...
journal_title：Rheumatology international
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00296-019-04261-4
更新日期：2019-06-01 00:00:00
abstract：:The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observationa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3814-2
更新日期：2017-11-01 00:00:00
abstract：:Dermatomyositis (DM) is a rare inflammatory disorder affecting the muscle and skin. DM patients can present with spontaneous muscle hemorrhage, a potentially fatal complication. The best practice for management of hemorrhagic myositis in these patients remains unclear. Here we discuss the case of a patient who present...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04501-7
更新日期：2020-02-01 00:00:00
abstract：:The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method comb...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270983
更新日期：1989-01-01 00:00:00
abstract：:A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia ...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-013-2924-8
更新日期：2014-04-01 00:00:00
abstract：:Recent data suggest that childhood and adulthood stressors may play a significant role in the development of an autoimmune disease. The present study explores the relationship between psoriatic arthritis (PsA) and positive and negative life events during childhood and adulthood in psoriatic patients. Forty-five patien...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2569-z
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVES:X-ray is the fundamental imaging technique in both diagnosis and follow-up of rheumatic diseases. As patients often require sequential X-rays over many years, dose reduction is of great importance. New advanced noise reduction algorithms allow for a dose reduction of up to 50%. The aim of this study was to e...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04560-1
更新日期：2020-06-01 00:00:00
abstract：:Protein synthesis in all cells is readily interrupted by environmental stresses such as hyperthermia. However, stressed cells also have mechanisms which, even under conditions where normal protein synthesis is completely inhibited, allow them to synthesise a group of highly conserved proteins--the so-called heat shock...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/BF00541323
更新日期：1990-01-01 00:00:00
abstract：:The family name of author Francesco La Torre was incorrect in the published article. The correct family name should read as La Torre F. ...
journal_title：Rheumatology international
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00296-018-4042-0
更新日期：2018-07-01 00:00:00
