Abstract:
:The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method combined with autoradiography that identifies DNA synthesis and, thus, activation. Most of the activated T lymphocytes in reactive arthritis were found to belong to the CD8 suppressor/cytotoxic T-lymphocyte subset. In striking contrast, the majority of the activated T lymphocytes detected in rheumatoid arthritis (RA) synovial fluid belonged to the CD4 helper/inducer subset. These findings agree well with the assumption that CD8-positive cells identify the foreign antigen in the context of class I antigens, whereas CD4-positive cells are found to be associated with the recognition of MHC locus II coded HLA antigens.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Nordström DCdoi
10.1007/BF00270983subject
Has Abstractpub_date
1989-01-01 00:00:00pages
269-72issue
6eissn
0172-8172issn
1437-160Xjournal_volume
8pub_type
杂志文章abstract::Non-tuberculous mycobacteria (NTM) are an unusual cause of osteomyelitis in immunocompetent children. Diagnosis is often difficult due to the paucity of clinical symptoms and a subtle course of the disease. NTM comprise a group of about 91 identified species of environmental mycobacteria that cause infections most fre...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0844-4
更新日期:2009-10-01 00:00:00
abstract::Familial Mediterranean fever is characterized by self-limited attacks of serositis and arthritis. However, substantial number of patients suffer from chronic complications of this disease, primarily involving musculoskeletal system. Treatment for these complications is challenging due to limited evidence. Interleukin-...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04490-7
更新日期:2020-01-01 00:00:00
abstract::We aimed to investigate the diagnostic significance of high frequency ultrasonography (USG), comparing the findings in USG, bone scintigraphy and clinical stuation. Fifty-one patients who had early symptoms of inflammatory arthritis, but not fulfilling the ACR diagnostic criteria for rheumatoid arthritis (RA) were inc...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0765-7
更新日期:2009-05-01 00:00:00
abstract::The family name of author Francesco La Torre was incorrect in the published article. The correct family name should read as La Torre F. ...
journal_title:Rheumatology international
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00296-018-4042-0
更新日期:2018-07-01 00:00:00
abstract::Antibodies to citrullinated proteins and rheumatoid factor (RF) are widely used in patients with rheumatoid arthritis (RA) and the antibodies to citrullinated proteins appear to be the most specific markers of the disease. The objective was to compare the diagnostic performance of the anti-cyclic citrullinated peptide...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0980-x
更新日期:2010-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and J...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3358-2
更新日期:2016-02-01 00:00:00
abstract::CD28 is one of the main activator receptors involved in systemic lupus erythematosus (SLE) pathogenesis, and its expression and serum levels are significantly higher in patients with SLE and other autoimmune diseases than in healthy controls (HC). However, it is unknown whether this increase is associated with specifi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1479-1
更新日期:2011-10-01 00:00:00
abstract::Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1374-9
更新日期:2011-06-01 00:00:00
abstract::The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0461-z
更新日期:2008-03-01 00:00:00
abstract::We present the case of a patient with long-standing rheumatoid arthritis and an acute onset of total dysfunction of the posterior tibial tendon. On MRI, a rupture of the tendon was apparent. Intraoperatively, however, massive tenosynovitis with stricture of the tendon was identified as the cause of posterior tibial te...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0183-1
更新日期:2002-05-01 00:00:00
abstract::The Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is an inclusive questionnaire, able to describe the total impairments and restrictions due to axial spondyloarthritis (axSpA). Considering the relationship between ASAS HI and the Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP,...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3642-9
更新日期:2017-05-01 00:00:00
abstract::The aim of this study was to identify the possible determinants of impaired health-related quality of life (HRQOL) in Egyptian children and adolescents with juvenile idiopathic arthritis (JIA). Fifty-eight consecutive patients of JIA aged from 8 to 18 years underwent assessment of socio-economic and demographic charac...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-2950-1
更新日期:2014-08-01 00:00:00
abstract::The case of a 29-year-old white female with a 7-year history of typical scleroderma is presented who developed excessive fibrosis of the supraclavicular lymph nodes. After 3 years of disease, firm right supraclavicular lymphadenopathy appeared, accompanied by a high fever. Biopsy revealed non-caseating granulomas and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301013
更新日期:1993-01-01 00:00:00
abstract::Low molecular weight IgM (LMW IgM) is the monomeric subunit of the naturally occurring pentameric IgM. It is not seen in health but has been previously observed in systemic lupus erythematosus (SLE) particularly in those patients with active disease and may reflect an adverse prognostic finding. We have therefore stud...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274821
更新日期:1990-01-01 00:00:00
abstract::To define and give priority to standards of care and quality indicators of multidisciplinary care for patients with psoriatic arthritis (PsA). A systematic literature review on PsA standards of care and quality indicators was performed. An expert panel of rheumatologists and dermatologists who provide multidisciplinar...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3986-4
更新日期:2018-06-01 00:00:00
abstract::The aim of the study was the thermovisual comparison of mean temperature of hand surface changes after local cryotherapy with vapors of nitrogen (-160°C) and cold air (-30°C). Forty-seven patients with rheumatoid arthritis (39 women and 8 men; average age 56.2 ± 10.5 years) were included in the study. They had the app...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-011-2078-5
更新日期:2012-10-01 00:00:00
abstract::Most infectious agents, such as viruses, bacteria and parasites, can trigger autoimmunity via different mechanisms. The development of an autoimmune disorder after infection tends to occur in genetically susceptible individuals. Some parameters, such as genetic predisposition, feature of the infectious agent and somet...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-012-2451-z
更新日期:2012-11-01 00:00:00
abstract::Arachnoid ossificans is a rare type of chronic arachnoiditis characterised by the presence of calcification or ossification of the dura and arachnoid. There are a few reports of these findings in relation to various disease entities, but only one case has been reported in relation to ankylosing spondylitis. We describ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2293-0
更新日期:2013-06-01 00:00:00
abstract::To investigate changes in the risk for serious infections (SIs) over time in Japanese rheumatoid arthritis (RA) patients treated with tumor necrosis factor inhibitors (TNFIs). This prospective cohort study included Japanese RA patients who began treatment with a TNFI from 2005 to 2007 (2005 group, n = 716, 634.2 patie...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-014-3045-8
更新日期:2014-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease characterized by the production of autoantibodies against a spectrum of nuclear antigens. RANTES and its receptor CCR5 have been associated with the pathogenesis of SLE. The objective of this study is to analyze autoantibodies (DNA/RNA), al...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2812-2
更新日期:2013-11-01 00:00:00
abstract::To evaluate the efficacy and safety of infliximab biosimilar CT-P13 in patients with active Takayasu arteritis (TAK). In this single-center open-label trial, patients with active TAK received CT-P13 at a starting dose of 5 mg/kg at weeks 0, 2, 6, and then every 8 weeks up to week 46. They were followed up until week 5...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-018-4159-1
更新日期:2018-12-01 00:00:00
abstract::We characterized the anemia in monkey collagen-induced arthritis (CIA) to evaluate whether this model is useful to analyze the basis of an anemia of inflammatory diseases. Cynomolgus monkey was immunized with bovine type II collagen on days 0 and 21. Blood samples were collected regularly and hematological parameters,...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0547-2
更新日期:2008-07-01 00:00:00
abstract::Abstract A 66-year-old woman showing renal dysfunction with elevated serum alkaline phosphatase and anti-SS-A antibody was admitted. A labial salivary gland biopsy showing infiltration of mononuclear cells and positive anti-SS-A antibody with sicca symptoms led to a diagnosis of primary Sjögren’s syndrome (SS). Fancon...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0924-5
更新日期:2009-12-01 00:00:00
abstract::3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301776
更新日期:1995-01-01 00:00:00
abstract::Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF02274749
更新日期:1990-01-01 00:00:00
abstract::We examined the intracellular mechanisms of substance P induced oxyradical production in rheumatoid synovial cells by the luminol-dependent chemiluminescence method. After stimulation with substance P (30 microM), single synovial A (macrophage-like) or B (fibroblast-like) cells released oxyradicals such as superoxide ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF01419729
更新日期:1996-01-01 00:00:00
abstract::Dermatomyositis (DM) is a rare inflammatory disorder affecting the muscle and skin. DM patients can present with spontaneous muscle hemorrhage, a potentially fatal complication. The best practice for management of hemorrhagic myositis in these patients remains unclear. Here we discuss the case of a patient who present...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04501-7
更新日期:2020-02-01 00:00:00
abstract::The purpose of this study was to determine the effects of an oral preparation containing hyaluronic acid on osteoarthritic knee joint pain and function as well as changes in inflammatory cytokines, bradykinin, and leptin. We also used heavy water to determine the turnover rates of glycosaminoglycans in synovial fluid....
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-014-3047-6
更新日期:2015-01-01 00:00:00
abstract::The Australian/Canadian Osteoarthritis Hand Index (AUSCAN) is a patient self-reported 15-item questionnaire measuring the severity of hand osteoarthritis symptoms in the respect of pain, stiffness, and function. In this study, we developed a Korean version of the AUSCAN Index (K-AUSCAN) and confirmed its reliability, ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2227-x
更新日期:2012-11-01 00:00:00
abstract::Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were fi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541284
更新日期:1986-01-01 00:00:00