Abstract：
:Low molecular weight IgM (LMW IgM) is the monomeric subunit of the naturally occurring pentameric IgM. It is not seen in health but has been previously observed in systemic lupus erythematosus (SLE) particularly in those patients with active disease and may reflect an adverse prognostic finding. We have therefore studied the presence of LMW IgM in 33 Chinese or Malay SLE patients (Singapore) and 21 Caucasian patients (Adelaide). LMW IgM was measured using filtration chromatography or by a sensitive immunoblotting technique. LMW IgM was observed in all patients in the Adelaide group and in 32 patients in the Singapore group with slightly greater quantities being seen in the Adelaide group. LMW IgM constituted up to 15.3% of the total IgM and was frequently associated with the presence of other low molecular weight IgM oligomers. In both groups LMW IgM correlated significantly with the total IgM levels (P less than 0.01). In a more detailed study in the Singapore group LMW IgM also correlated significantly with the IgM anticardiolipin levels (P = 0.02) but not with IgG anticardiolipin or with IgG or IgM anti-DNA levels or with rheumatoid factor. Patients with more extensive organ involvement had higher levels of LMW IgM but not at a significant level. We conclude that circulating LMW IgM occurs almost universally in SLE, is closely related to the total IgM levels and appears independent of ethnic background. The significance of LMW IgM in this disorder is unclear.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Roberts-Thomson PJ,Shepherd K,Bradley J,Boey MLdoi
10.1007/BF02274821subject
Has Abstractpub_date
1990-01-01 00:00:00pages
95-8issue
3eissn
0172-8172issn
1437-160Xjournal_volume
10pub_type
杂志文章abstract：:Rheumatoid vasculitis (RV) is an uncommon but potentially catastrophic complication of rheumatoid arthritis (RA). There are few current extensive studies and no consensus regarding the clinical, laboratory, histologic features and management or prognosis of RV. We report a case of RV in a 74-year old woman with a long...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0592-x
更新日期：2008-10-01 00:00:00
abstract：:Protein synthesis in all cells is readily interrupted by environmental stresses such as hyperthermia. However, stressed cells also have mechanisms which, even under conditions where normal protein synthesis is completely inhibited, allow them to synthesise a group of highly conserved proteins--the so-called heat shock...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/BF00541323
更新日期：1990-01-01 00:00:00
abstract：:An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3774-6
更新日期：2017-10-01 00:00:00
abstract：:We investigated the effect of chrysotherapy on the Fc and complement receptor binding activity of peripheral blood (PB) monocytes and peritoneal (PE) macrophages isolated from normal rats and rats with adjuvant induced arthritis. The adjuvant induced severe disease in Dark Agouti (DA) rats and less marked disease in J...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270454
更新日期：1988-01-01 00:00:00
abstract：:The aim of this study was to determine the association between individual and external exposure factors, and the reporting of Raynaud's phenomenon, with or without concomitant cold sensitivity. In a population-based nested case-control study, cases with Raynaud's phenomenon (N = 578), and matched controls (N = 1156), ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4133-y
更新日期：2019-02-01 00:00:00
abstract：:We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000054
更新日期：2000-01-01 00:00:00
abstract：:The efficacy of balneotherapy in fibromyalgia syndrome (FS) has been well demonstrated, while controlled studies using mud packs are lacking. We performed a randomized clinical trial to evaluate the effects and the tolerability of mud-bath treatment in FS patients, who are poor responders to pharmacological therapy. E...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00296-007-0358-x
更新日期：2007-10-01 00:00:00
abstract：:Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0638-0
更新日期：2008-11-01 00:00:00
abstract：:The aim of this study was to evaluate the total antioxidant status (TAS), total oxidative status (TOS) and oxidative stress index (OSI) in patients with postmenopausal osteoporosis. We also investigate the relation between bone mineral density and oxidative/antioxidative parameters. Thirty-nine patients with osteoporo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0452-0
更新日期：2008-02-01 00:00:00
abstract：:Here we evaluated whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have beneficial effects for collagen-induced arthritis (CIA). DBA/1 mice were immunized with bovine type-II collagen and administered 100 mg/kg of pravastatin interperitoneally. We measured the effects of pravastatin for CIA...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0270-9
更新日期：2007-05-01 00:00:00
abstract：:Smoking produces substances that activate proinflammatory, prothrombotic and vasoconstrictive mediators via posttranslational carbamylation of proteins. As a new consequence of carbamylation, induction of anti-carbamylated autoantibodies were observed in rheumatoid arthritis (RA) patients, sometimes prior to onset of ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3472-9
更新日期：2016-06-01 00:00:00
abstract：:We have examined the way in which products of cultured human blood mononuclear cells activate human articular chondrocytes. Conditioned medium from mononuclear cells enhanced the production of prostaglandin E by cultured human chondrocytes and also stimulated fibrinolytic activity in these cultures. These two effects ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541204
更新日期：1984-01-01 00:00:00
abstract：:Rheumatoid arthritis is a systemic autoimmune disease resulting in joint destruction and deformities, but also associated with extraarticular and systemic manifestations. The later devastating conditions, such as the development of rheumatoid vasculitis, are more frequently encountered in seropositive patients and the...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3861-8
更新日期：2018-01-01 00:00:00
abstract：:We have investigated the prevalence of dry mouth among patients with autoimmune diseases other than Sjögren's syndrome. One hundred and forty-four patients, excluding patients with primary Sjögren's syndrome, were enrolled in this study. The volume of saliva secreted was measured with the screening technique for estim...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2611-1
更新日期：2013-12-01 00:00:00
abstract：:The ultrastructural localisation of class II and macrophage antigens has been sought in the intimal layer of the human synovium. The cells described as type A in early morphological studies are shown to express both class II antigens and two markers of the macrophage/monocyte lineage of cells, OKM1 and MAB 24. The mor...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270456
更新日期：1988-01-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is an autoimmune spondyloarthropathy involving principally the sacroiliac joint and axial skeleton. Spinal cord involvement is an infrequent and late complication. It mostly results from compressive myelopathy due to skeletal osteopathy and usually presents with radiculomyelopathic sensory ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1614-z
更新日期：2011-07-01 00:00:00
abstract：:The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method comb...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270983
更新日期：1989-01-01 00:00:00
abstract：:Circulating endothelial progenitor cells (EPCs) are reduced in patients with systemic lupus erythematosus (SLE). A reduced number of EPCs are associated with the presence of atherosclerosis in other populations. We sought to determine whether the reduction in EPC numbers in SLE is dependent on the presence of advanced...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1730-9
更新日期：2012-04-01 00:00:00
abstract：:The aim of the study was to analyze the concentrations of sTNFR1 and sTNFR2 in both plasma and synovial fluid of patients with primary knee osteoarthritis (OA) and to determine their relationship to self-reported pain, stiffness and physical function. Twenty-seven patients with knee OA and 19 healthy subjects were enr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3016-0
更新日期：2014-12-01 00:00:00
abstract：:We examined the intracellular mechanisms of substance P induced oxyradical production in rheumatoid synovial cells by the luminol-dependent chemiluminescence method. After stimulation with substance P (30 microM), single synovial A (macrophage-like) or B (fibroblast-like) cells released oxyradicals such as superoxide ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF01419729
更新日期：1996-01-01 00:00:00
abstract：:Monocyte interleukin-1 (IL-1) production in vitro was studied in 49 patients with rheumatoid arthritis (RA) and 31 controls. Twenty-six of the RA patients were studied prospectively for up to 12 months after beginning chrysotherapy. About half of the patients (group 1) exhibited pretreatment levels of monocyte IL-1 se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274840
更新日期：1990-01-01 00:00:00
abstract：:The objective of the study is to investigate the clinical characteristics and long-term prognosis including flares and organ damage in patients with giant cell arteritis (GCA) from a tertiary referral centre and compare these features in different subgroups. In this retrospective observational study, patients with GCA...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04730-1
更新日期：2021-02-01 00:00:00
abstract：:Biological treatments aiming to neutralize TNF-alpha (tumour necrosis factor alpha) (infliximab, adalimumab and etanercept) are increasingly used to treat rheumatoid arthritis (RA). Although increased frequency has not been observed in randomized clinical trials with TNF-alpha antagonist agents, postmarketing surveill...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0165-9
更新日期：2006-11-01 00:00:00
abstract：:Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement is very rare in sarcoidosis. The objective of this report was to evaluate a rare involvement of sarcoidosis. This report includes a case of nasopharyngeal sarcoidosis. A 51-year-old female with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1866-2
更新日期：2012-05-01 00:00:00
abstract：:The main goal of this project was to identify the presence of fibromyalgia (FM) subgroups using a simple and frequently used clinical tool, the Fibromyalgia Impact Questionnaire (FIQ). A total of 61 women diagnosed with FM participated in this study. FM subgroups were created by applying a hierarchical cluster analysi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0722-5
更新日期：2009-03-01 00:00:00
abstract：:We studied the relationships between physician-assessed damage, severity and activity in a large, multicentre systemic sclerosis (SSc, scleroderma) cohort. We hypothesized that there is a relationship between disease activity and severity and damage, but that severity would be more strongly related to damage. A total ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1129-7
更新日期：2010-07-01 00:00:00
abstract：:We have recently reported on two cases of scleroderma patients with ANCA-associated vasculitis for the first time in Korea. In order to explore the nature of this disease combination, we pooled together all the previously known cases and statistically analyzed them. Out of the 50 selected cases, survival analysis was ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-005-0011-5
更新日期：2006-03-01 00:00:00
abstract：:Macrophage activation syndrome (MAS) is a clinical syndrome caused by an excessive proliferation of T lymphocytes and well-differentiated macrophages; an entity distinct from malignant histiocytosis. Although rheumatologic conditions are the common cause of MAS, a wide range of infections are also seen to cause MAS. W...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1033-1
更新日期：2010-06-01 00:00:00
abstract：:The aims of this systematic review and meta-analysis were to: (1) describe the prevalence of commonly reported comorbidities in psoriatic arthritis (PsA), (2) compare the incidence and/or prevalence of comorbidities between PsA and control populations; and (3) examine the impact of comorbidities on PsA outcomes. We sy...
journal_title：Rheumatology international
pub_type：
doi：10.1007/s00296-020-04775-2
更新日期：2021-02-01 00:00:00
abstract：:Behçet's disease (BD) commonly presents with articular manifestations and thrombotic vasculopathy. Arthritis of BD characteristically demonstrates a recurrent and nondestructive course. The pathobiological basis of the thrombotic vasculopathy and protective factors against cartilage destruction in arthritis of BD have...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0324-1
更新日期：2004-03-01 00:00:00
