Abstract:
:CD28 is one of the main activator receptors involved in systemic lupus erythematosus (SLE) pathogenesis, and its expression and serum levels are significantly higher in patients with SLE and other autoimmune diseases than in healthy controls (HC). However, it is unknown whether this increase is associated with specific organ damage. Therefore, our objective was to measure the CD28 levels in serum from SLE and HC groups to confirm the CD28 serum levels increase, as reported previously, and to determine whether this increase was associated with specific organ activity and the SLE Disease Activity Index (SLEDAI). Forty SLE patients and 40 matched HC were included, and the age, disease duration, SLEDAI and Mexican SLEDAI were recorded for the SLE group. CD28 serum levels were measured by ELISA. There was a statistically significant increase in the CD28 serum levels of SLE patients compared to controls (p = 0.039); however, we did not find any significant correlation with disease activity indices or organ involvement, although we found a significant but low correlation with C3. Our results and a review of the literature suggest that the increase in CD28 serum levels may be the result of CD28 gene overexpression, which could be related to the decrease in CD28+ T cells, T-cell hyporesponsiveness and immune impairment that occurs in SLE.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Brambila-Tapia AJ,Gámez-Nava JI,Salazar-Páramo M,Munoz-Valle JF,González-López L,Llamas-Covarrubias MA,Gutiérrez-Urena SR,Vázquez-Del Mercado M,Dávalos-Rodríguez IPdoi
10.1007/s00296-010-1479-1subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1321-1324issue
10eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
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