Abstract:
:Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease characterized by the production of autoantibodies against a spectrum of nuclear antigens. RANTES and its receptor CCR5 have been associated with the pathogenesis of SLE. The objective of this study is to analyze autoantibodies (DNA/RNA), allelic distribution of RANTES and the association of levels of RANTES and its receptor CCR5 in SLE patients in North Indian region. The RANTES-403 and RANTES-28 polymorphism in the promoter region of RANTES gene was studied in 80 patients and 80 healthy controls. The levels of chemokine RANTES, its receptor CCR5, anti-dsDNA, and anti-SSA antibodies levels were determined. Disease activity was assessed with the systemic lupus erythematosus disease activity index (SLEDAI) score. All the parameters were studied for statistical analysis by using t test (graph pad prism) and correlation by SPSS data. PCR-RFLP performed showed 28C/C and the 403G/G genotypes in both patients and controls, but no other genotypes such as 28C/G, 28G/G and 403A/G, 403A/A were found. Patients had higher levels of RANTES (1840.48 ± 739.42 vs. 835.44 ± 70.48 pg/ml; P < 0.0001) and its receptor CCR5 expression (26.49 ± 0.16 vs. 24.72 ± 3.02 %; P < 0.05) compared to controls. The levels of autoantibodies anti-dsDNA and anti-SSA were also higher in patients than controls. The patients showing elevated anti-dsDNA had negative correlation with SLEDAI score (P < 0.05) while borderline patients were not found to be correlated. In case of anti-Ro/anti-SSA antibody levels, the borderline patients showed a moderately significant negative correlation as compared to controls than patients with elevated autoantibody (P < 0.01). The levels of RANTES and CCR5 were also higher in case of patients than controls. But there was no significant correlation of RANTES and CCR5 with disease activity. We were unable to find an association of RANTES polymorphism with SLE in North Indian population in our sample. No significant difference in allele distribution of RANTES-28 and RANTES-403 in the sample of 160 individuals was detected. Of the two autoantibodies studied, anti-Ro/anti-SSA levels in borderline lupus patients appeared as an important parameter for monitoring/diagnosis of lupus patients.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Bidyalaxmi Devi L,Bhatnagar A,Wanchu A,Sharma Adoi
10.1007/s00296-013-2812-2subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2819-26issue
11eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract::The family name of author Francesco La Torre was incorrect in the published article. The correct family name should read as La Torre F. ...
journal_title:Rheumatology international
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00296-018-4042-0
更新日期:2018-07-01 00:00:00
abstract::One hundred and eighteen unrelated Greek patients with classic rheumatoid arthritis (RA) were tissue-typed for HLA-A, -B, -DR antigens and the frequency was compared to that of healthy controls. Greek RA patients regardless of sex, anatomical severity, seropositivity and age at disease onset are not associated with an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541336
更新日期:1985-01-01 00:00:00
abstract::Neopterin levels of serum and fluid were determined in 30 patients with inflammatory synovial fluids and in 30 controls with joint effusions induced by trauma or osteoarthritis. Neopterin was significantly elevated in inflammatory fluids. There was no correlation with the acute phase reactants. Neopterin levels were s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541281
更新日期:1986-01-01 00:00:00
abstract::31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00291145
更新日期:1991-01-01 00:00:00
abstract::We report on a 69-year-old woman who presented with myalgia, hearing impairment, fever, night sweats, weight loss, muscular weakness, paresthesia, hypesthesia, and hypalgesia. Sural nerve biopsy showed demyelinative and axonal polyneuropathy due to necrotizing vasculitis with fibrinoid necrosis. A positive test for an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960000063
更新日期:2000-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) patients have high risk for anxiety and depression. We aimed to investigate the prevalence and risk factors of anxiety and depression in SLE patients in Southwest China. Participants were recruited by convenience sampling from Rheumatic Outpatient Clinic of West China Hospital Sichua...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3559-3
更新日期:2016-12-01 00:00:00
abstract::We evaluated the frequency of secondary amyloidosis, associated clinical features, and outcomes in ankylosing spondylitis (AS) patients diagnosed in the last decade. The medical records of AS patients diagnosed at single academic medical center were reviewed for clinical evidence of amyloidosis. During routine follow-...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2646-3
更新日期:2013-07-01 00:00:00
abstract::Treatment of acute gout consists of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and steroids. However, the typical patient with gout has multiple comorbidities such as cardiovascular disease, hypertension, renal dysfunction or diabetes/metabolic syndrome that represent contraindications to these therape...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-020-04659-5
更新日期:2020-12-01 00:00:00
abstract::The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0461-z
更新日期:2008-03-01 00:00:00
abstract::This study was designed to determine the effects of the osteoprotegerin (OPG) on the mRNA expression of carbonic anhydrase II (CAII) and the receptor activator of NF-κB (RANK) in mouse osteoclast-like cells. Marrow cells were harvested from femora and tibiae of mouse and cultured in 6-well chamber slides. After 1 day ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2338-4
更新日期:2012-12-01 00:00:00
abstract::Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0616-6
更新日期:2008-11-01 00:00:00
abstract::The presence of specific anti-Proteus antibodies in active, rheumatoid arthritis (RA) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, ELISA, Western blotting and immunofluorescence. Furthermore, anti-HLA-DR4 tissue typing sera have been shown to bind to Proteus microorga...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/BF00271885
更新日期:1989-01-01 00:00:00
abstract::A case of relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome is described. The pattern of vascular involvement supports the inclusion of relapsing polychondritis within the spectrum of systemic vasculitides. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541214
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:Neprilysin (neutral endopeptidase, 3:4:24:11, CD10) (NEP) is a Zn metallopeptidase linked to controlling inflammation through the degradation of neuropeptides involved in neurogenic inflammation of chronic rheumatic diseases. The aim of our study was to evaluate circulating activity and cellular expression of...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0447-z
更新日期:2005-06-01 00:00:00
abstract::A period of 4 weeks (w) has been recommended for rheumatoid arthritis (RA) patients as the interval between intravenous (IV) tocilizumab (TCZ, 8 mg/kg). In a previous paper, we showed the possibility that the interval between successive IV TCZ can be extended from 4 to 6 weeks in more than 60% of patients with low dis...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4149-3
更新日期:2018-12-01 00:00:00
abstract::The aims of this systematic review and meta-analysis were to: (1) describe the prevalence of commonly reported comorbidities in psoriatic arthritis (PsA), (2) compare the incidence and/or prevalence of comorbidities between PsA and control populations; and (3) examine the impact of comorbidities on PsA outcomes. We sy...
journal_title:Rheumatology international
pub_type:
doi:10.1007/s00296-020-04775-2
更新日期:2021-02-01 00:00:00
abstract::This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960050097
更新日期:1999-01-01 00:00:00
abstract::We report a 34-year-old female case of diffuse systemic sclerosis (SSc) with generalized ectopic calcification, who developed severe headache with vertical atlantoaxial subluxation (AAS) complicated by calcification around the odontoid process (crowned dens pattern calcification). Although a rare complication, AAS sho...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1703-z
更新日期:2011-09-01 00:00:00
abstract::CCL28 is a mucosa-associated epithelial-cell-produced chemokine involved in oral defense. We assessed the level of CCL28 in saliva of primary Sjögren's syndrome (pSS) patients in comparison with healthy controls and correlated it with IgA salivary levels. We included 30 non-smoker pSS patients and 30 non-smoker health...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3210-0
更新日期:2015-08-01 00:00:00
abstract::Using a sensitive and specific enzyme-linked immunosorbent assay (ELISA) assay we showed that the cryoglobulins of a patient with Lucio phenomenon contain phenolic glycolipid I antigen and a specific antibody. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541512
更新日期:1986-01-01 00:00:00
abstract::Infliximab, a monoclonal chimeric anti-tumor necrosis factor alpha (anti-TNF-alpha) antibody, was tried in two patients suffering from severe refractory juvenile ankylosing spondylarthritis with disease duration of more than 10 years. To assess the response, validated clinical activity parameters were monitored prospe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0378-0
更新日期:2004-05-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scar...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00296-017-3784-4
更新日期:2017-10-01 00:00:00
abstract::The diagnosis of Kawasaki disease (KD), a common pediatric vasculitis, is based solely on clinical criteria. There is a need for a robust laboratory marker that can help differentiate KD from other acute, febrile, childhood illnesses and also to predict cardiac involvement. We conducted a cross-sectional study of 25 c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3430-6
更新日期:2016-04-01 00:00:00
abstract::Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 pat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2821-1
更新日期:2013-11-01 00:00:00
abstract::We hypothesise that T-cell apoptosis and the percentage of T cells expressing molecules involved in apoptosis modulation (CD95, CD28) are altered at the inflammation site and in peripheral blood (PB) of children with juvenile idiopathic arthritis (JIA). Paired JIA samples of synovial fluid (SF) and PB ( n=7) and PB sa...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0263-2
更新日期:2003-05-01 00:00:00
abstract::As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibr...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-007-0403-9
更新日期:2007-09-01 00:00:00
abstract::The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0210-2
更新日期:2002-07-01 00:00:00
abstract::We have examined the way in which products of cultured human blood mononuclear cells activate human articular chondrocytes. Conditioned medium from mononuclear cells enhanced the production of prostaglandin E by cultured human chondrocytes and also stimulated fibrinolytic activity in these cultures. These two effects ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541204
更新日期:1984-01-01 00:00:00
abstract::To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological gui...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3201-1
更新日期:2015-06-01 00:00:00
abstract::The objective of this research was to investigate the cellular source of soluble ICAM-1 (siCAM-1) from rheumatoid synovial tissue (RS) and its relation to sICAM-1 in synovial fluid (SF) and serum, and to study the expression of ICAM-1 in isolated cells of RS. sICAM-1 was determined by using the enzyme-linked immunosor...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/pl00006846
更新日期:1997-01-01 00:00:00