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Absence of salivary CCL28 in primary Sjögren's syndrome.

Abstract：

:CCL28 is a mucosa-associated epithelial-cell-produced chemokine involved in oral defense. We assessed the level of CCL28 in saliva of primary Sjögren's syndrome (pSS) patients in comparison with healthy controls and correlated it with IgA salivary levels. We included 30 non-smoker pSS patients and 30 non-smoker healthy controls paired by age (±5 years). Saliva samples were collected during the morning and kept frozen at -86 °C until the analysis. Fifty microliters of saliva was diluted 3:1 with water and analyzed for CCL28 salivary levels by ELISA method. The samples were tested in triplicate. IgA salivary levels were tested by ELISA method. We used descriptive statistics, Mann-Whitney U test and Kendall's tau correlation coefficients. pSS patients were mostly females (93.3 %), mean age 54.5 ± 13.3 years and median disease duration of 7.6 years (0.5-33). Patients with pSS had lower levels of salivary CCL28 when compared with controls [0 (0-1,272 pg/ml) vs. 94.4 (0-5,810) pg/ml, p < 0.0001]. pSS patients also had lower median levels of salivary IgA [72.55 μg/ml (0.40-297.4)] than controls [131.9 μg/ml (6.8-281.8)], although the latter results did not reach statistical significance (p = 0.51). Among the SS group, there was no correlation between CCL28 and IgA salivary levels nor between salivary IgA and disease duration, salivary flow, serum immunoglobulins or dental loss. CCL28 was absent in saliva of pSS patients; however, this finding did not correlate with salivary IgA levels.

journal_name

Rheumatol Int

journal_title

Rheumatology international

authors

Hernandez-Molina G,Burkhardt AM,Lima G,Zlotnik A,Betanzos JL,Bahena S,Llorente L

doi

10.1007/s00296-014-3210-0

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

1431-4

issue

8

eissn

0172-8172

issn

1437-160X

journal_volume

35

pub_type

杂志文章

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