Abstract：
:Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 patients undergoing joint replacement and in 680 control subjects. SNPs were located in WNT1, WNT10A, WNT16, DVL2, FZD5, BCL9, SFRP1, TCF7L1 and SFRP4 genes. SNPs significantly associated with OA were genotyped in an independent group of 369 patients and 407 controls. One SNP in WNT10A, rs3806557, was associated with hip OA in men (OR 0.65, 95% CI 0.46-0.93; p = 0.017), but the association was not confirmed in the replication phase. The TCF7L1 polymorphism rs11547160 was also associated with hip OA in the discovery set, but not in the replication set. Similarly, the SFRP4 SNP rs1052981 was associated with knee OA in women with OR of 2.73 (95% CI 1.29-5.8; p = 0.006), but the association was not replicated. The BCL9 polymorphism rs2353525 was associated with knee OA in women, both in the unadjusted and in the age- and BMI-adjusted analysis (OR 2.01; 95% CI 1.34-2.98; p = 0.0006). A similar, but not statistically significant, trend was observed in the replication phase. In the combined analysis, OR was 3.13 (1.34-7.28; p = 0.009). These data suggest that some SNPs of genes related to the Wnt pathway and, specifically BCL9, influence the genetic predisposition to osteoarthritis of the large joints in a sex- and joint-specific way.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
García-Ibarbia C,Pérez-Castrillón JL,Ortiz F,Velasco J,Zarrabeitia MT,Sumillera M,Riancho JAdoi
10.1007/s00296-013-2821-1subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2875-80issue
11eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract：:A 56-year-old woman presented with changes characteristic of the reflex sympathetic dystrophy syndrome (RSDS) but also frank synovitis of the left wrist, an elevated ESR and early damage of the left carpus on radiographs, suggesting septic arthritis. A dynamic scan showed changes characteristic of RSDS. A sample of sy...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541334
更新日期：1985-01-01 00:00:00
abstract：:Human parvovirus B19 (B19) rarely induces pure red cell aplasia (PRCA) in healthy hosts. Meanwhile B19 infection is often clinically similar to systemic lupus erythematosus (SLE), and several cases have been reported wherein B19 actually stimulated SLE exacerbation in an immunocompetent subject. An 82-year-old healthy...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0227-z
更新日期：2007-02-01 00:00:00
abstract：:Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2199-x
更新日期：2012-11-01 00:00:00
abstract：:We studied causes of death (CoDs) between 1952 and 1991 assessed by a clinician before autopsy and then determined at autopsy by a pathologist in 369 subjects with rheumatoid arthritis (RA) and 370 subjects without RA (non-RA). We analysed clinical data for RA subjects between 1973 and 1991. In RA subjects, leading au...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0685-6
更新日期：2008-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541512
更新日期：1986-01-01 00:00:00
abstract：:Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0616-6
更新日期：2008-11-01 00:00:00
abstract：:Splenectomy may be necessary to treat systemic lupus erythematosus (SLE) patients with thrombocytopenia; however, whether performing a splenectomy on patients without SLE increases the subsequent risk of SLE remains unknown. Therefore, this study was conducted to determine the association between splenectomy and SLE. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3388-9
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abstract：:Low-dose radiotherapy (LD-RT) has been widely used for treatment of non-malignant disorders since its introduction and animal studies show anti-inflammatory effects in osteoarthritis (OA). However, the evidence for its effect in clinical practice remains unclear. Therefore, the aim of this study is to systematically s...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3337-7
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abstract：:Elderly often have Heberden nodes (HN) and Bouchard nodes (BN) that may affect finger dexterity. The aim of this cross-sectional study was to assess an effect of HN and BN on finger dexterity of the elderly. The nine-hole peg test was used for dexterity measurement in 200 elderly with HN and/or BN. Mean age was 68.6 +...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1196-9
更新日期：2010-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3266-5
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abstract：:Among the clinical manifestations of systemic lupus erythematosus is an arthropathy, which is usually non-erosive. In many cases, the joint involvement is mild. A subset of patients has deforming, non-erosive Jaccoud's arthropathy, and a minority have an arthropathy with clinical findings similar to rheumatoid arthrit...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1176-0
更新日期：2010-09-01 00:00:00
abstract：:This study examines whether or not MBD4 polymorphism is a marker for rheumatoid arthritis (RA) susceptibility or severity for Chinese patients in Taiwan. This study included 193 patients with RA, while 190 unrelated healthy individuals living in Central Taiwan served as controls. The relationship between MBD4 polymorp...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1545-8
更新日期：2012-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/BF00541323
更新日期：1990-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2483-4
更新日期：2013-10-01 00:00:00
abstract：:The objective of this study is to investigate the clinical markers of life-threatening Pneumocystis pneumonia (PCP) in patients with collagen vascular diseases (CVD). The patients who contracted Pneumocystis jeroveccii were retrospectively selected from our medical charts and conditions related to the patients' death ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0857-z
更新日期：2009-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/pl00006851
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abstract：:Familial Mediterranean fever is a chronic inflammatory disease characterized by periodic and self-limited episodes of fever and aseptic polyserositis. Although colchicine treatment has altered the course of the disease, it is believed that subclinical inflammation is still present, leading to endothelial dysfunction a...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
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journal_title：Rheumatology international
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journal_title：Rheumatology international
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journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
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更新日期：2017-04-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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abstract：:Tribal differences are demonstrated in the presentation of lupus in Omani Gulf Arabs (OGA) and Omani Arabs of Persian descent (OAP), both groups resident in and indigenous to the Sultanate of Oman. The OAP have a lower risk of joint complications, skin rash, and dsDNA antibodies than OGA (beta coefficient and 95% conf...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-001-0151-1
更新日期：2002-01-01 00:00:00
abstract：:Histoplasmosis is an important cause of morbidity in endemic areas of the USA. Infection is often asymptomatic but can cause a broad spectrum of pathology. Less commonly, histoplasmosis can present with a wide-range of rheumatologic manifestations. The aim of this review is to provide a synopsis of the rheumatologic m...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-013-2816-y
更新日期：2013-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1252-5
更新日期：2011-03-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
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更新日期：2013-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270984
更新日期：1989-01-01 00:00:00
abstract：:Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3385-z
更新日期：2016-03-01 00:00:00
abstract：:We have investigated the prevalence of dry mouth among patients with autoimmune diseases other than Sjögren's syndrome. One hundred and forty-four patients, excluding patients with primary Sjögren's syndrome, were enrolled in this study. The volume of saliva secreted was measured with the screening technique for estim...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2611-1
更新日期：2013-12-01 00:00:00
