Abstract:
:To investigate the expression and effect of farnesoid X receptor (FXR) on systemic lupus erythematosus (SLE) liver dysfunction and indicate its hepatoprotective role and the immunomodulatory property. mRNA and protein levels of FXR were determined on the liver specimens of SLE patients with liver injury as well as MRL/lpr rodent models. The FXR agonist chenodeoxycholic acid (CDCA) was administrated to MRL/lpr mice and the control BALB/C with concanavalin A (ConA)-induced liver injury. Blood samples were taken 0, 4, 8, 12, 16, and 24 h after ConA injection for the detection of serum ALT, AST, IFN-γ, TNF-α, and IL-6. FXR was down-regulated at both mRNA and protein levels in the liver specimens of SLE patients with liver injury as well as MRL/lpr mice. MRL/lpr was more susceptible to ConA than BALB/C indicated by significantly higher levels of aminotransferase and inflammatory cytokines. Activation of FXR by CDCA significantly reduced aminotransferase and inflammatory cytokines IFN-γ, TNF-α, and IL-6 caused by ConA injection in MRL/lpr mice. FXR was down-regulated in SLE patients as well as MRL/lpr lupus models with liver dysfunction. FXR activation ameliorated liver injury and suppressed inflammatory cytokines, thereby showing its protective function in SLE. Our findings raised the promising potential target for the treatment of SLE liver injury.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Lian F,Wang Y,Chen J,Xu H,Yang X,Liang L,Zhan Z,Ye Y,Chen Mdoi
10.1007/s00296-011-1874-2subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1705-10issue
6eissn
0172-8172issn
1437-160Xjournal_volume
32pub_type
杂志文章abstract::The efficacy of balneotherapy in fibromyalgia syndrome (FS) has been well demonstrated, while controlled studies using mud packs are lacking. We performed a randomized clinical trial to evaluate the effects and the tolerability of mud-bath treatment in FS patients, who are poor responders to pharmacological therapy. E...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00296-007-0358-x
更新日期:2007-10-01 00:00:00
abstract::The effect of knee OA on kinetic and kinematic parameters during walking and standing is still controversial. Stability and energy consumption have not been well investigated in patients with OA. This research investigated the parameters distinguishing between the healthy subjects and patients with OA performance. It ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2639-2
更新日期:2013-07-01 00:00:00
abstract::Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1 mA, 10 Hz EA ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1364-y
更新日期:2011-06-01 00:00:00
abstract::The prevalence of overweight and obesity in patients with fibromyalgia is high, which makes these patients more likely to trigger metabolic changes. It is also uncertain whether the clinical manifestations of fibromyalgia alter the metabolism in these patients. This study investigates the influence of adiposity indica...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-2988-0
更新日期:2014-11-01 00:00:00
abstract::The aim of the study was the thermovisual comparison of mean temperature of hand surface changes after local cryotherapy with vapors of nitrogen (-160°C) and cold air (-30°C). Forty-seven patients with rheumatoid arthritis (39 women and 8 men; average age 56.2 ± 10.5 years) were included in the study. They had the app...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-011-2078-5
更新日期:2012-10-01 00:00:00
abstract::A previously healthy 40-year-old woman presented as unstable angina. She had a family history of stroke as the only cardiovascular risk factor. Her blood pressure on admission was 150/90 mmHg. Laboratory study showed absolutely all negative markers of inflammation, autoimmune disorders, or atherosclerosis. Coronary an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0739-9
更新日期:2009-04-01 00:00:00
abstract::The purpose of the present study was to evaluate the toxicity and tolerability of methotrexate (MTX)/gold (G; group 1) combination therapy as compared to other MTX combinations [MTX with hydroxychloroquine (HCQ; group 2), MTX with sulphasalazine (SASP; group 3) and MTX with minocycline (MNC; group 4)]. The hospital re...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/pl00006851
更新日期:1997-01-01 00:00:00
abstract::The role of free radicals in fibromyalgia is controversial. In this study, 85 female patients with primary fibromyalgia and 80 age-, height-, and weight-matched healthy women were evaluated for oxidant/antioxidant balance. Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of free radical dam...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0427-8
更新日期:2005-04-01 00:00:00
abstract::Schistosomiasis or bilharzia is a parasitic disease found in tropical countries. Most infections are subclinical but may progress to chronic form characterized most frequently by the presence of liver involvement and portal hypertension. We report a patient that presented chronic polyarthritis with positive rheumatoid...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1562-7
更新日期:2013-05-01 00:00:00
abstract::Activation of opioid receptors on peripheral sensory nerve terminals by opioid peptides that are produced and released from immune cells can result in inhibition of inflammatory pain. This study tests the hypothesis that postoperative pain is attenuated endogenously through a local sympathetic neurotransmitter-activat...
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-010-1489-z
更新日期:2011-10-01 00:00:00
abstract::We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA). The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar sp...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0391-3
更新日期:2004-09-01 00:00:00
abstract::In a randomized multicenter, double-blind, double-dummy, parallel group study a comparison of the efficacy and safety of 1 microg alfacalcidol to 880 IU vitamin D plus calcium carbonate (1 g calcium) once daily per os was performed on 148 postmenopausal osteoporotic Caucasian patients with normal vitamin D serum level...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00296-005-0073-4
更新日期:2006-03-01 00:00:00
abstract::The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual X-ray absorptiometry), cumulative glucocorticoid dose, age, disease duration, body mass index (BMI) and parameters of dis...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0576-x
更新日期:2008-09-01 00:00:00
abstract::Diffuse idiopathic skeletal hyperostosis (DISH) is difficult to distinguish from various forms of inflammatory arthritis, including psoriatic arthritis (PsA), rheumatoid arthritis, and ankylosing spondylitis. A 67-year-old Japanese male had been treated for psoriasis vulgaris for 13 years. Numbness of his right arm an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1368-7
更新日期:2012-05-01 00:00:00
abstract::Tumor necrosis factor (TNF) antagonists are among the most effective therapies for rheumatoid arthritis (RA), yet not all patients show a response. Using meta-analysis, this present study was designed to investigate whether or not the TNF-alpha promoter -308 A/G polymorphism is associated with responsiveness to anti-T...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s00296-006-0175-7
更新日期:2006-12-01 00:00:00
abstract::Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0357-5
更新日期:2004-07-01 00:00:00
abstract::Advanced glycation endproducts (AGEs) are the products of non-enzymatic glycation and oxidation of proteins and lipids. Low-turnover tissues such as articular cartilage seem to be susceptible to the accumulation of AGEs, which might lead to cartilage degradation. Recently, a non-invasive method for measuring skin AGE ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0408-4
更新日期:2007-12-01 00:00:00
abstract::Methotrexate (MTX) can be toxic to patients suffering from end stage renal disease (ESRD) on hemodialysis even at low doses. This increase in toxicity is more notable in terms of bone marrow suppression in the form of pancytopenia. Many methods of elimination including dialysis itself have been proven ineffective, and...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-011-2041-5
更新日期:2011-12-01 00:00:00
abstract::Elderly often have Heberden nodes (HN) and Bouchard nodes (BN) that may affect finger dexterity. The aim of this cross-sectional study was to assess an effect of HN and BN on finger dexterity of the elderly. The nine-hole peg test was used for dexterity measurement in 200 elderly with HN and/or BN. Mean age was 68.6 +...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1196-9
更新日期:2010-02-01 00:00:00
abstract::This study was performed to identify the role of cholinergic stimulation on changes of intracellular calcium concentrations as intracellular messenger of neuroimmune interaction. Incubation of PBMC with acetylcholine (ACh) leads to Ca(2+) oscillations in healthy controls. PBMC from rheumatoid arthritis (RA) patients e...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0723-4
更新日期:2009-03-01 00:00:00
abstract::Therapeutics targeting sphingosine-1-phosphate (S1P), a kind of lipid mediator regulating immune cell trafficking, has been emerging rapidly as a novel line of regimen for autoimmune diseases, including rheumatoid arthritis (RA). Here, we propose that S1P-targeted therapy is beneficial not only for limiting inflammati...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1634-8
更新日期:2011-07-01 00:00:00
abstract::The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observationa...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3814-2
更新日期:2017-11-01 00:00:00
abstract::Takayasu arteritis (TA) is a rare autoimmune disease of unknown etiology. Genome-wide association studies (GWAS) have demonstrated association between genetic variants of IL12B and IL6 and TA. Since TA has been reported with ethnic heterogeneity, we sought to investigate whether the single-nucleotide-polymorphisms (SN...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-016-3648-3
更新日期:2017-04-01 00:00:00
abstract::Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily involving the spine and sacroiliac joint and rarely the kidneys. This study aimed to define the clinical and histological features and biology of renal disease in AS. We reviewed the medical records of 681 patients diagnosed with AS from November ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2624-9
更新日期:2013-07-01 00:00:00
abstract::Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541352
更新日期:1985-01-01 00:00:00
abstract::The aim of this study was to investigate the association of three polymorphisms of CD154 with risk of SLE in Chinese population. The study population comprised 770 Chinese individuals, including 350 SLE patients and 420 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3745-y
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0556-8
更新日期:2006-01-01 00:00:00
abstract::As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibr...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-007-0403-9
更新日期:2007-09-01 00:00:00
abstract::The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evid...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541376
更新日期:1987-01-01 00:00:00
abstract::Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2199-x
更新日期:2012-11-01 00:00:00