Abstract：
:The role of free radicals in fibromyalgia is controversial. In this study, 85 female patients with primary fibromyalgia and 80 age-, height-, and weight-matched healthy women were evaluated for oxidant/antioxidant balance. Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of free radical damage. Superoxide dismutase is an intracellular antioxidant enzyme and shows antioxidant capacity. Pain was assessed by visual analog scale. Tender points were assessed by palpation. Age, smoking, body mass index (BMI), and duration of disease were also recorded. Malondialdehyde levels were significantly higher and superoxide dismutase levels significantly lower in fibromyalgic patients than controls. Age, BMI, smoking, and duration of disease did not affect these parameters. We found no correlation between pain and number of tender points. In conclusion, oxidant/antioxidant balances were changed in fibromyalgia. Increased free radical levels may be responsible for the development of fibromyalgia. These findings may support the hypothesis of fibromyalgia as an oxidative disorder.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Bagis S,Tamer L,Sahin G,Bilgin R,Guler H,Ercan B,Erdogan Cdoi
10.1007/s00296-003-0427-8subject
Has Abstractpub_date
2005-04-01 00:00:00pages
188-90issue
3eissn
0172-8172issn
1437-160Xjournal_volume
25pub_type
杂志文章abstract：:This study investigated the prevalence of antibody against annexin II (A2) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored the role of this antibody in thrombosis. Purified recombinant A2 was used in ELISA to measure the levels of IgG anti-A2 antibody in 101 AP...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1379-4
更新日期：2011-07-01 00:00:00
abstract：:Osteopoikilosis, a form of osteosclerotic disorders, is a rare bone dysplasia with typical radiologic findings. The pathology, which sometimes requires attention in differential diagnosis due to its radiologic appearance, has been reported previously with other diseases. In this report, a case diagnosed with both reac...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0037-8
更新日期：2006-05-01 00:00:00
abstract：:Genetic polymorphisms in cytokine genes, which influence gene expression, may have an important impact on SLE susceptibility and severity. The aim of this study was to examine the possible influence of two functional polymorphisms in cis-regulatory regions of IL12B gene in the susceptibility and clinical symptoms of S...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1547-6
更新日期：2012-01-01 00:00:00
abstract：:Intraocular inflammation is one of the more relevant complications of Behçet's disease (BD), which tends to respond poorly to different medications. The ocular histopathologic changes are basically identical to those occurring in other organs and consist in a necrotizing leukocytoclastic obliterative vasculitis, which...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3775-5
更新日期：2018-01-01 00:00:00
abstract：:Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children and adolescents who had undergone serum uric acid (SUA) measurement at the Chang Gung Memorial Hospital betwe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2808-y
更新日期：2013-11-01 00:00:00
abstract：:Tuberculosis (TB) is an important preventable infection in patients with rheumatoid arthritis (RA). To determine the risk of TB in patients with RA by comparing with those with non-specific back pain (NSBP), and to identify the risk factors in the RA group. Medical data were retrieved from a centralized electronic dat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04583-8
更新日期：2020-06-01 00:00:00
abstract：:The objectives of this study are to describe appropriateness and drug treatment of comorbidities in fibromyalgia (FM). Cross-sectional study of a group of patients. Number of drugs, indication, duration and appropriateness of prescriptions were evaluated. Patients were classified as: group 1, (FM/FM) previous FM diagn...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3568-2
更新日期：2016-12-01 00:00:00
abstract：:Familial Mediterranean fever is characterized by self-limited attacks of serositis and arthritis. However, substantial number of patients suffer from chronic complications of this disease, primarily involving musculoskeletal system. Treatment for these complications is challenging due to limited evidence. Interleukin-...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04490-7
更新日期：2020-01-01 00:00:00
abstract：:The current study was to investigate the quantity and quality of researches in the field of ankylosing spondylitis, and to reveal the characteristics of worldwide productivity on this disease. This was a bibliometric study on ankylosing spondylitis using Web of Science. The numbers of papers, citations, research outpu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04308-6
更新日期：2019-06-01 00:00:00
abstract：:We studied the relationships between physician-assessed damage, severity and activity in a large, multicentre systemic sclerosis (SSc, scleroderma) cohort. We hypothesized that there is a relationship between disease activity and severity and damage, but that severity would be more strongly related to damage. A total ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1129-7
更新日期：2010-07-01 00:00:00
abstract：:The aim of this study was to investigate the influence of various weather parameters on pain intensity levels in patients with acute low back pain (LBP). We performed a secondary analysis using data from the PACE trial that evaluated paracetamol (acetaminophen) in the treatment of acute LBP. Data on 1604 patients with...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3419-6
更新日期：2016-05-01 00:00:00
abstract：:A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04414-5
更新日期：2019-12-01 00:00:00
abstract：:This review explores the prevalence and factors associated with disturbed sleep for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis in order to clarify consistent findings in this otherwise disparate research field. The association of physical, demographic and psychological factors co...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-016-3589-x
更新日期：2017-02-01 00:00:00
abstract：:This study examines whether or not MBD4 polymorphism is a marker for rheumatoid arthritis (RA) susceptibility or severity for Chinese patients in Taiwan. This study included 193 patients with RA, while 190 unrelated healthy individuals living in Central Taiwan served as controls. The relationship between MBD4 polymorp...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1545-8
更新日期：2012-01-01 00:00:00
abstract：:The objective of this study was to analyze the clinical characteristics, associated disorders, and the most common sites of stress fractures in rheumatological patients. Over a 3-year period, 35 patients with 44 stress fractures were prospectively recruited from an outpatient rheumatological department (32 postmenopau...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0194-y
更新日期：2002-06-01 00:00:00
abstract：:Rheumatoid vasculitis (RV) is an uncommon but potentially catastrophic complication of rheumatoid arthritis (RA). There are few current extensive studies and no consensus regarding the clinical, laboratory, histologic features and management or prognosis of RV. We report a case of RV in a 74-year old woman with a long...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0592-x
更新日期：2008-10-01 00:00:00
abstract：:The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0461-z
更新日期：2008-03-01 00:00:00
abstract：:Takayasu's arteritis (TA) is a rare chronic vasculitis of the aorta and its main branches. Infectious agents or autoimmunity are thought to influence the pathophysiology. Ethnic preponderance in East Asia and usually affects young Asian women suggesting a possible role of genetic factor in the etiology. We present a r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1234-7
更新日期：2011-06-01 00:00:00
abstract：:The aim of the study is to investigate the levels of serum interleukin-35 (IL-35) before and after treatment and its relationship with clinical parameters as well as the frequency of different subsets of CD4+ T cells in patients with systemic sclerosis (SSc) to explore the role of IL-35 in the pathogenesis of SSc. The...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4071-8
更新日期：2018-08-01 00:00:00
abstract：:Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2340-x
更新日期：2013-01-01 00:00:00
abstract：:We describe the case of a 59 year old man with systemic sclerosis and superficial siderosis of the central nervous system characterized by progressive worsening of walking with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia. Ferritin and oligoclonal bands were found on lumbar ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0523-x
更新日期：2008-06-01 00:00:00
abstract：:Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270349
更新日期：1986-01-01 00:00:00
abstract：:Currently, many studies have focused on the possibility of using mean platelet volume (MPV) as a biomarker for disease activity in patients with systemic lupus erythematosus (SLE). To derive a more accurate estimation, a meta-analysis was conducted. Embase, PubMed, The Cochrane Library database and several Chinese dat...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-018-4065-6
更新日期：2018-09-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) related to hepatitis B is an uncommon vasculitis that is sometimes associated with the rapid progression of distal ischemia. A few recent reports have proposed the use of antiviral therapy. However, there is not yet a consensus for the standard treatment of this disease entity and none of th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0103-x
更新日期：2006-08-01 00:00:00
abstract：:Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541597
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVES:We aimed to assess the clinical significance of Krebs von den Lungen-6 (KL-6) in the diagnosis and severity of interstitial lung disease (ILD) in a French cohort of patients with systemic sclerosis (SSc). METHODS:Serum KL-6 concentrations were measured with chemiluminescent enzyme immunoassay (CLEIA) in 75 ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-3987-3
更新日期：2018-05-01 00:00:00
abstract：:Primary Sjögren syndrome (pS) is associated with autoantibodies such as rheumatoid factor (RF) and anti-nuclear antibodies such as anti-Ro (SS-A) and/or La (SS-B). Recent developments within autoimmune diagnostics allow quantitation of RF subclasses and anti-Ro epitopes. Will this refinement by autoimmune diagnostics ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4090-5
更新日期：2018-08-01 00:00:00
abstract：:TNF-α is one of the key proinflammatory cytokines in pathogenesis of rheumatoid arthritis (RA). TNF-α was also found to enhance synthesis of leptin. Leptin is mainly adipocyte-derived hormone controlling appetite and energy expenditure. It acts through inhibition of neuropeptide Y secretion. It is possible that TNF-α-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2182-6
更新日期：2012-11-01 00:00:00
abstract：:In a randomized multicenter, double-blind, double-dummy, parallel group study a comparison of the efficacy and safety of 1 microg alfacalcidol to 880 IU vitamin D plus calcium carbonate (1 g calcium) once daily per os was performed on 148 postmenopausal osteoporotic Caucasian patients with normal vitamin D serum level...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00296-005-0073-4
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:The prevalence of dermatophytic infections in rheumatoid arthritis is unknown. This study investigated the prevalence of dermatophytosis in patients with rheumatoid arthritis and the relationship between sulfasalazine, low-dose methotrexate and steroid therapy. METHODS:We examined 53 consecutive patients wit...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0238-3
更新日期：2003-01-01 00:00:00
