Abstract:
:Intraocular inflammation is one of the more relevant complications of Behçet's disease (BD), which tends to respond poorly to different medications. The ocular histopathologic changes are basically identical to those occurring in other organs and consist in a necrotizing leukocytoclastic obliterative vasculitis, which is probably immune complex-mediated and affects both arteries and veins of all sizes. There are growing evidences showing the potential role of biologic agents other than anti-tumor necrosis factor (TNF)-α agents in the management of ocular-BD, which have been collected in this review, including interleukin-1 and interleukin-6 blockade, secukinumab, ustekinumab, daclizumab, rituximab, and alemtuzumab. Further large studies are needed to fully elucidate and establish the clinical efficacy of these different tools in the refractory ocular manifestations of BD.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Sota J,Rigante D,Lopalco G,Frediani B,Franceschini R,Galeazzi M,Iannone F,Tosi GM,Fabiani C,Cantarini Ldoi
10.1007/s00296-017-3775-5subject
Has Abstractpub_date
2018-01-01 00:00:00pages
25-35issue
1eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-017-3775-5journal_volume
38pub_type
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