Abstract：
:This study was performed to identify the role of cholinergic stimulation on changes of intracellular calcium concentrations as intracellular messenger of neuroimmune interaction. Incubation of PBMC with acetylcholine (ACh) leads to Ca(2+) oscillations in healthy controls. PBMC from rheumatoid arthritis (RA) patients exhibited increased basal Ca(2+) concentrations with a significantly reduced capacity to respond upon ACh stimulation compared to healthy controls. It can be assumed that cholinergic signals in PBMC are mediated via the nicotinergic type of ACh receptors, causing changes in intracellular Ca(2+) concentrations with various types of oscillations. The significantly decreased modulation of intracellular Ca(2+) levels by ACh in PBMC of RA patients points further to a disturbed neuroimmune interaction in this chronic disease.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Nast A,Malysheva O,Krause A,Wahle M,Baerwald CGdoi
10.1007/s00296-008-0723-4subject
Has Abstractpub_date
2009-03-01 00:00:00pages
497-502issue
5eissn
0172-8172issn
1437-160Xjournal_volume
29pub_type
杂志文章abstract：:The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen ind...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274777
更新日期：1990-01-01 00:00:00
abstract：:The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1176-0
更新日期：2010-09-01 00:00:00
abstract：:Fibromyalgia (FM), pre-dominantly found in women, may accompany other pre-existing rheumatic diseases. The association between FM and ankylosing spondylitis (AS) is uncertain. We evaluated FM in women with AS. Eighteen women with AS were compared with 18 men with AS (controls) for age, duration of symptoms, time to di...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0344-3
更新日期：2007-07-01 00:00:00
abstract：:The aim of this study is to determine whether and to which extent pentosidine (PEN) is influenced in the case of advanced osteoarthritis (OA) in urine and in some tissues. Reverse phase HPLC method for PEN determination with fluorescence monitoring was utilized. Urinary pentosidine (U-PEN) and pyridinoline (U-PD) were...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0105-8
更新日期：2006-08-01 00:00:00
abstract：:3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00301776
更新日期：1995-01-01 00:00:00
abstract：:Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3864-5
更新日期：2018-05-01 00:00:00
abstract：:Fibromyalgia syndrome is characterized by chronic generalized pain accompanied by a broad symptomatologic spectrum. Besides chronic fatigue, sleep disturbances, headaches and cognitive dysfunction that are extensively described in the literature, a considerable proportion of patients with fibromyalgia experience gastr...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-014-3109-9
更新日期：2015-03-01 00:00:00
abstract：:Wells' syndrome is a multifaceted dermatosis with a wide morphological spectrum, ranging from characteristic cellulitis-like erythema and papula to an unusual presentation of vesicles and pustules. The most important elements for diagnosis are erythemal plaques and histological picture of eosinophilic infiltration of ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1809-y
更新日期：2012-04-01 00:00:00
abstract：:Therapeutic proteins, such as infliximab, have revolutionized the treatment of many diseases during the last decade and more than 80 therapeutic proteins are currently approved for clinical use. However, all exogenous proteins have the potential to cause antibody formation. In order to ensure patient safety and the ef...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0085-0
更新日期：2006-03-01 00:00:00
abstract：:Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (tota...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0502-9
更新日期：2005-05-01 00:00:00
abstract：:The objective of this study was to evaluate human papillomavirus (HPV) and Chlamydia trachomatis (CT) infections in RA patients pre- and post-TNF blocker. Fifty female RA patients (ACR criteria), who were eligible to anti-TNF therapy [n = 50 at baseline (BL) and n = 45 after 6 months of treatment (6 M)], and 50 age-ma...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3157-1
更新日期：2015-03-01 00:00:00
abstract：:To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological gui...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3201-1
更新日期：2015-06-01 00:00:00
abstract：:To evaluate serum levels of IL6 in patients with Kawasaki disease and compare it with CRP, and to assess the role of these biomarkers in predicting coronary changes and resistance to the first-line therapy of this disease in a subset of Indian population. A single centre prospective observational study was conducted a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04375-9
更新日期：2019-10-01 00:00:00
abstract：:This study evaluates prospectively whether baseline scores [Health Assessment Questionnaire (HAQ) and SF-36] can predict clinical and radiographic evolution in a cohort of early rheumatoid arthritis (RA) during a 3-year follow-up. Forty consecutive early RA patients were followed for 3 years, while receiving standardi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2261-8
更新日期：2012-12-01 00:00:00
abstract：:The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s002960050066
更新日期：1998-01-01 00:00:00
abstract：:Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,评审
doi：10.1007/BF02274749
更新日期：1990-01-01 00:00:00
abstract：:Microscopic polyangiitis is a small-vessel necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies and presents itself with glomerulonephritis and hemorrhagic pulmonary capillaritis. Peripheral nervous system involvement is common in anti-neutrophil cytoplasmic antibodies-associated vasculitis, b...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-016-3424-4
更新日期：2016-07-01 00:00:00
abstract：:The objective of this study was to translate and evaluate the psychometric properties of the Thai version of the Rheumatoid Arthritis Disease Activity Index (RADAI) in patients with rheumatoid arthritis (RA). We translated and modified the original RADAI into the Thai version. A total of 116 Thai patients with RA were...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2749-5
更新日期：2013-10-01 00:00:00
abstract：:Tuberculosis can affect sacroiliac joints, but only a few such cases have been reported. The onset is usually insidious, and early diagnosis requires a high index of clinical suspicion. We report herein a culture-proven case of tuberculous sacroiliitis which initially mimicked neoplastic infiltration on CT scan. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0406-0
更新日期：2004-09-01 00:00:00
abstract：:To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-4150-x
更新日期：2018-12-01 00:00:00
abstract：:Nitric oxide (NO) is a free radical that plays important roles in many physiological and pathological processes. Evidence suggests that NO participates in the pathogenesis of inflammatory reactions in many autoimmune and inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this study was to evaluate...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002960100105
更新日期：2001-05-01 00:00:00
abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have poor prognosis, and pulmonary endarterectomy (PEA) is considered the treatment of choice for this condition. We report a case and review the literature of successful PEA for CTEPH due to antiphospholipid syndrome associated with systemic lupus er...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2346-4
更新日期：2013-07-01 00:00:00
abstract：:Not all patients with osteoarthritis (OA) show the same disease progression, as some of them remain relatively stable over time, while others progress to severe structural deterioration of the joint. In this sense, the main goal of both genetic and protein biomarkers in OA is to predict not only the risk of OA at an e...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3104-1
更新日期：2015-02-01 00:00:00
abstract：:Biological treatments aiming to neutralize TNF-alpha (tumour necrosis factor alpha) (infliximab, adalimumab and etanercept) are increasingly used to treat rheumatoid arthritis (RA). Although increased frequency has not been observed in randomized clinical trials with TNF-alpha antagonist agents, postmarketing surveill...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0165-9
更新日期：2006-11-01 00:00:00
abstract：:Takayasu arteritis (TA) is a rare autoimmune disease of unknown etiology. Genome-wide association studies (GWAS) have demonstrated association between genetic variants of IL12B and IL6 and TA. Since TA has been reported with ethnic heterogeneity, we sought to investigate whether the single-nucleotide-polymorphisms (SN...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-016-3648-3
更新日期：2017-04-01 00:00:00
abstract：:Celiac disease (CD) is an autoimmune systemic disease characterized by not only gastrointestinal but also extraintestinal manifestations. The aim of our study was to do a serological screening for CD, by IgA endomysial antibodies (EmA), in patients with unexplained articular manifestations. Two hundred and eleven pati...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-013-2906-x
更新日期：2014-05-01 00:00:00
abstract：:The aim of this study was to assess the changes in the characteristics of rheumatoid arthritis information on the Internet over a 15-year period and the positioning of Web sites posted by universities, hospitals, and medical associations. We replicated the methods of a 2001 study assessing rheumatoid arthritis informa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3507-2
更新日期：2016-09-01 00:00:00
abstract：:The capillaroscopic pattern in paraneoplastic Raynaud's phenomenon (RP) has not been investigated systematically and is not well-defined. Here, we present three case reports of patients with paraneoplastic rheumatic conditions, manifested with severe secondary RP with emphasis upon capillaroscopic findings. The first ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1715-8
更新日期：2013-06-01 00:00:00
abstract：:Our aim was to evaluate fatigue and quality of life (QoL) in Moroccan patients with primary Sjögren's syndrome (PSS) and determine their correlates with disease-related parameters. Fifty-seven consecutive patients with PSS according to the American-European Consensus group (AEGG) criteria were included. Demographic, c...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2009-5
更新日期：2012-09-01 00:00:00
abstract：:Folate supplementation is widely accepted and utilized for the prevention of adverse events in juvenile idiopathic arthritis (JIA) patients who are treated with methotrexate. Despite the widespread use of folate supplementation, there is a lack of convincing evidence to support the role of folate in the enhancement of...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2696-1
更新日期：2013-09-01 00:00:00
