Abstract：
:We studied the depletion and repopulation of synovial lining cells in mice. A single intra-articular injection of liposomes encapsulating the drug dichloromethylene diphosphonate (CL2MDP) in the mouse knee joint caused selective elimination of synovial lining cells. Depletion of cells occurred within a few days as evidenced by light microscopic, electronmicroscopic and immunohistochemical studies. Maximal depletion was seen on day 7. Repopulation was observed in the following weeks, starting at the bone side of the joint. Until day 30, full recovery (60% recovery) was not observed in the lining lying adjacent to the dermis. Side effects on cartilage metabolism, such as inhibition of proteoglycan synthesis or degradation of proteoglycans from the matrix was minor but significant, 1 and 2 days after liposome treatment but thereafter full recovery was observed. Selective elimination of lining cells from the joint enabled us to study the in vivo role of these cells in the onset and subsequent pathology of experimental arthritis. An immune-complex-mediated experimental arthritis elicited in lining cell depleted joints that had received CL2MDP-liposomes 7 days earlier prevented inflammation as compared to controls.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
van Lent PL,van den Bersselaar L,van den Hoek AE,van de Ende M,Dijkstra CD,van Rooijen N,van de Putte LB,van den Berg WBdoi
10.1007/BF00290330subject
Has Abstractpub_date
1993-01-01 00:00:00pages
21-30issue
1eissn
0172-8172issn
1437-160Xjournal_volume
13pub_type
杂志文章abstract：:The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1alpha and tumor necrosis factor (TNF) alpha, and the concentration...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0350-5
更新日期：2007-09-01 00:00:00
abstract：:Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with dela...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-013-2771-7
更新日期：2013-09-01 00:00:00
abstract：:To evaluate the efficacy and safety of infliximab biosimilar CT-P13 in patients with active Takayasu arteritis (TAK). In this single-center open-label trial, patients with active TAK received CT-P13 at a starting dose of 5 mg/kg at weeks 0, 2, 6, and then every 8 weeks up to week 46. They were followed up until week 5...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-018-4159-1
更新日期：2018-12-01 00:00:00
abstract：:The objective of the study is to assess the disease course and associated healthcare costs in a cohort of established rheumatoid arthritis (RA) patients in Turkey. The study cohort consisted of 75 RA patients from our outpatient clinic who took part in a previous multicenter study assessing RA-related healthcare costs...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04574-9
更新日期：2020-07-01 00:00:00
abstract：:The aim of this study was to evaluate the effectiveness of intravenous corticosteroid therapy when Henoch-Schönlein purpura (HSP) patients are unable to tolerate oral medications due to abdominal pain. We retrospectively analyzed 111 children with a diagnosis of HSP (mean age 6.9 ± 2.3 years, male:female = 54:57) from...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1507-1
更新日期：2011-11-01 00:00:00
abstract：:In recent years, scientific efforts on the topic "gout" have focused on pathogenetic aspects. This has opened new strategies of anti-inflammatory therapy and has improved urate-lowering therapy. So far, a scientometric analysis of the topic "gout" has not been generated despite an increased need for it in times of mod...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2805-1
更新日期：2013-11-01 00:00:00
abstract：:Human parvovirus B19 (B19) rarely induces pure red cell aplasia (PRCA) in healthy hosts. Meanwhile B19 infection is often clinically similar to systemic lupus erythematosus (SLE), and several cases have been reported wherein B19 actually stimulated SLE exacerbation in an immunocompetent subject. An 82-year-old healthy...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0227-z
更新日期：2007-02-01 00:00:00
abstract：:Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease. Of the numerous organ manifestations, involvement of the upper and lower gastrointestinal tract (GIT) appears to be the most frequent with regard to the clinical symptoms. However, as the frequency and clinical relevance of GI involvement in p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1988-6
更新日期：2012-08-01 00:00:00
abstract：:The current study was to investigate the quantity and quality of researches in the field of ankylosing spondylitis, and to reveal the characteristics of worldwide productivity on this disease. This was a bibliometric study on ankylosing spondylitis using Web of Science. The numbers of papers, citations, research outpu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04308-6
更新日期：2019-06-01 00:00:00
abstract：:In patients suffering from ankylosing spondylitis (AS) HLA-B27 determination by means of the microlymphocytotoxicity test (MLCT) sometimes gives equivocal or false-negative results even though it has been performed with meticulous care. These failures of the test did not arise when the isolated mononuclear cells (MNC)...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00301265
更新日期：1993-01-01 00:00:00
abstract：:The objective of the study was to investigate the possibility whether the in vitro treatment with vitamin D3 can restore the impaired expression of protein kinase C (PKC) isoenzymes and IL-2 production in the lymphocytes of patients with systemic lupus erythematosus (SLE). Purified T lymphocytes from 14 patients with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2751-y
更新日期：2014-05-01 00:00:00
abstract：:To evaluate the correlation between measurements of antinuclear antibodies serum levels by enzyme immunoassay (ANA-EIA), and the degree of systemic lupus erythematosus disease activity. To retest the performance of the test compared to measurement of antinuclear antibodies by immunofluorescence (ANA-IIF). Eighty-five ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0324-7
更新日期：2007-08-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) affects women of childbearing age. To optimize fetal and maternal outcomes, effective reproductive health counseling is crucial. To analyze the effectiveness of reproductive health counseling in women with SLE and identify gaps in patient educational needs. Cross-sectional study incl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04671-9
更新日期：2021-02-01 00:00:00
abstract：:Activated T lymphocytes (Ia+ T-cells) in peripheral blood are associated with immune stimulation. We found the percentages of these cells significantly increased in 95% of rheumatoid arthritis (RA) patients. Our studies showed no relation between the percentages of these cells in peripheral blood and concurrent erythr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00272435
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:The present study was performed to localize the articular deposition of monosodium urate (MSU) crystal in joints. We compare the detection efficiencies of dual-energy CT (DECT) and ultrasound scans. METHODS:Analyses by DECT and ultrasound were performed with 184 bilateral joints of the lower limbs of 54 cons...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-3994-4
更新日期：2018-05-01 00:00:00
abstract：:Low-dose radiotherapy (LD-RT) has been widely used for treatment of non-malignant disorders since its introduction and animal studies show anti-inflammatory effects in osteoarthritis (OA). However, the evidence for its effect in clinical practice remains unclear. Therefore, the aim of this study is to systematically s...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3337-7
更新日期：2016-01-01 00:00:00
abstract：:The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s002960050066
更新日期：1998-01-01 00:00:00
abstract：:A 45-year-old female presented to the rheumatology clinic with complaint of pain and swelling of multiple small joints of the hands and feet. She also complained of cough and shortness of breath onset around the same time. Since her cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor tests were posi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-1294-8
更新日期：2011-12-01 00:00:00
abstract：:Some infectious, rheumatic, allergic diseases, and malignancies have been associated with leucocytoclastic vasculitis (LCV). LCV and cancer occur most frequently in patients with hematological malignancies such as lymphomas and leukemias. There have been a few prior cases reported of LCV associated with renal cell car...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1063-8
更新日期：2010-08-01 00:00:00
abstract：:We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000054
更新日期：2000-01-01 00:00:00
abstract：:Measurement of the complement activation products C1s:C1-inh, C3bP and C5b-9 by ELISA in plasma samples from normals, rheumatoid arthritis (RA) and systemic lupus erythematosis (SLE) patients showed significantly elevated levels in the two patient groups (P less than 0.0001 for C1s:C1-inh, C3bP and C5b-9) compared to ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274831
更新日期：1990-01-01 00:00:00
abstract：:Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distribu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541520
更新日期：1985-01-01 00:00:00
abstract：:A 56-year-old woman presented with changes characteristic of the reflex sympathetic dystrophy syndrome (RSDS) but also frank synovitis of the left wrist, an elevated ESR and early damage of the left carpus on radiographs, suggesting septic arthritis. A dynamic scan showed changes characteristic of RSDS. A sample of sy...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541334
更新日期：1985-01-01 00:00:00
abstract：:Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0616-6
更新日期：2008-11-01 00:00:00
abstract：:Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04386-6
更新日期：2019-09-01 00:00:00
abstract：:The objective of this study was to report 11 cases of propylthiouracil (PTU)-induced autoimmune syndromes. We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had vasculitis and 4 pa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1675-z
更新日期：2012-03-01 00:00:00
abstract：:This study was performed to evaluate the effects of the TNF-alpha inhibitor etanercept on oxidation stress markers representing DNA damage, lipid peroxidation, and protein glycosylation. Twenty-two rheumatoid arthritis (RA) patients underwent etanercept treatment. The levels of serum total, urinary total, and urinary ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0419-1
更新日期：2008-01-01 00:00:00
abstract：:An abnormal immune response towards the Epstein-Barr virus (EBV) has been documented in patients with rheumatoid arthritis (RA). To investigate whether these findings are due to the transformation event caused by EBV, RA blood mononuclear cells and monocyte-enriched preparations were incubated with two different EBV s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00271873
更新日期：1989-01-01 00:00:00
abstract：:We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3618-9
更新日期：2017-01-01 00:00:00
abstract：:Diffuse idiopathic skeletal hyperostosis (DISH) is difficult to distinguish from various forms of inflammatory arthritis, including psoriatic arthritis (PsA), rheumatoid arthritis, and ankylosing spondylitis. A 67-year-old Japanese male had been treated for psoriasis vulgaris for 13 years. Numbness of his right arm an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1368-7
更新日期：2012-05-01 00:00:00
