Abstract:
:The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measured three times (I, baseline; II, after 10-12 days; III, after 17-24 days) during a 3- or 4-week treatment at the health resort. At the same times, the variables for mobility were measured, and the patients were asked to assess their complaints (score) in a self-styled questionnaire. The serum concentration of IL-6 correlated with the measurements of occiput-to-wall distance, cervical rotation, finger-floor distance and Schober sign, and with morning pain at all three evaluations. Comparisons between changes in IL-6 and changes in the variables (measures of mobility, scores of the questionnaires) did not reveal significant correlations. Present data would suggest that in AS the serum concentration of IL-6 indicates the degree of mobility restriction resulting from previous disease progression, but is not a reliable marker of current disease activity.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Falkenbach A,Herold Mdoi
10.1007/s002960050066subject
Has Abstractpub_date
1998-01-01 00:00:00pages
103-6issue
3eissn
0172-8172issn
1437-160Xjournal_volume
18pub_type
临床试验,杂志文章abstract::The efficacy of balneotherapy in fibromyalgia syndrome (FS) has been well demonstrated, while controlled studies using mud packs are lacking. We performed a randomized clinical trial to evaluate the effects and the tolerability of mud-bath treatment in FS patients, who are poor responders to pharmacological therapy. E...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00296-007-0358-x
更新日期:2007-10-01 00:00:00
abstract::Using commercially available antigens, enzyme-linked immunosorbent assays (ELISAs) were set up to demonstrate antibodies of IgG class against Sm and SS-A. Anti-Sm antibodies were demonstrated in 40% of patients with systemic lupus erythematosus (SLE), in 12% of patients with SJögren's syndrome, in 6% of patients with ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00332564
更新日期:1991-01-01 00:00:00
abstract::Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04689-z
更新日期:2021-02-01 00:00:00
abstract::Macrophagic myofascitis (MMF) is an unusual inflammatory myopathy characterized by muscle infiltration by macrophages and lymphocytes. Here, we describe a case of MMF which is associated with rheumatoid arthritis. A 53-year-old Japanese rheumatoid arthritis (RA) patient presented with focal tenderness of lower extremi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1015-3
更新日期:2010-05-01 00:00:00
abstract::The risk of herpes zoster among patients with juvenile idiopathic arthritis (JIA) exposed to biologics has not been evaluated. We determined incidence rates of herpes zoster among children with JIA in correlation with medication at time of occurrence and total drug exposure. The German biologics register database was ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3197-6
更新日期:2015-03-01 00:00:00
abstract::The clinical use of pulsed electromagnetic fields (PEMF) in osteoarticular pathology is widely extended, although the mechanisms involved are unknown. The aim of this study was to evaluate the action of a new protocol of treatment with PEMF on liquid medium cultures of fibroblast-like cells derivates of mononuclear pe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1488-0
更新日期:2011-10-01 00:00:00
abstract::We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3618-9
更新日期:2017-01-01 00:00:00
abstract::Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3864-5
更新日期:2018-05-01 00:00:00
abstract::Routine assessment of patient index data 3 (RAPID3) is a simple, valid and reliable tool designed to measure disease activity in patients with rheumatoid arthritis (RA). RA causes significant disability and diminishes health-related quality of life (HR-QoL). The aim of this study was to investigate how RAPID3 is relat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04258-z
更新日期:2019-05-01 00:00:00
abstract::The synovial fluids (SF) of patients with rheumatoid arthritis (RA) were investigated for their effects on thymocytes of C3H/HeJ mice. Of the 20 SF tested, 17 (85%) showed an augmentation of the phytohaemagglutinin (PHA) induced thymocyte stimulation. Out of 16 SF of patients with osteoarthrosis, such an activity was ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541245
更新日期:1982-01-01 00:00:00
abstract::The objective of the study was to determine the clinical features and treatment course in Canadian patients with dermatomyositis (DM) associated with the anti-melanoma differentiation-associated gene 5 antibody (MDA5). A retrospective chart review of consecutive patients with anti-MDA5 antibody DM from two Canadian te...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04398-2
更新日期:2019-11-01 00:00:00
abstract::In a prospective study 222 sera from 56 patients with systemic lupus erythematosus (SLE) were tested for antibodies to poly(A), poly dAT and histones using enzyme-linked immunosorbent assay (ELISA). Patients with active disease had significantly more often antibodies to poly(A), poly dAT and histones than patients wit...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541200
更新日期:1984-01-01 00:00:00
abstract::Aseptic loosening is the predominant cause of total hip implant failure. It has been assumed that a layer or membrane, containing macrophages, fibroblasts and vascular endothelial cells, of synovial-like tissue develops at the implant-to-bone interface almost invariably and, with time, somehow leads to loosening of th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960050037
更新日期:1998-01-01 00:00:00
abstract::In Spain, the QUANTUM project has been promoted to reduce variability in clinical practice and improve the care and quality of life of people with psoriatic arthritis (PsA) by accrediting PsA units throughout the Spanish national health system. To present the results of this approach which sought to ensure an optimum ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04632-2
更新日期:2020-11-01 00:00:00
abstract::Various surgical procedures including percutaneous and open release and arthroscopic procedures have been described to treat recalcitrant tennis elbow. We present the outcome of Boyd-McLeod surgical procedure for tennis elbow resistant to non-operative treatment in twenty-seven patients (twenty-nine limbs). Boyd McLeo...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1450-1
更新日期:2011-08-01 00:00:00
abstract::Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial flu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0006-2
更新日期:2006-03-01 00:00:00
abstract::Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-009-1145-7
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the expression of apoptosis-related molecules in rheumatoid arthritis (RA) synovium, with special emphasis on the apoptosis accelerator Bax. METHODS:Immunohistochemical analysis of Bax, Bcl-2, and Bcl-x(L) was performed in tissue specimens of patients with RA and compared...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0255-2
更新日期:2003-03-01 00:00:00
abstract::Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541352
更新日期:1985-01-01 00:00:00
abstract::Tribal differences are demonstrated in the presentation of lupus in Omani Gulf Arabs (OGA) and Omani Arabs of Persian descent (OAP), both groups resident in and indigenous to the Sultanate of Oman. The OAP have a lower risk of joint complications, skin rash, and dsDNA antibodies than OGA (beta coefficient and 95% conf...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-001-0151-1
更新日期:2002-01-01 00:00:00
abstract::Rheumatoid vasculitis (RV) is an uncommon but potentially catastrophic complication of rheumatoid arthritis (RA). There are few current extensive studies and no consensus regarding the clinical, laboratory, histologic features and management or prognosis of RV. We report a case of RV in a 74-year old woman with a long...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0592-x
更新日期:2008-10-01 00:00:00
abstract::Accumulating evidence suggests that defects in the function of CD4(+)CD25(+) regulatory T cells (Tregs) are important in immune-mediated diseases such as rheumatoid arthritis. Here, we investigated the effects of various disease-modifying anti-rheumatic drugs (DMARDs) on Treg function. Tregs and CD4(+)CD25(-) effector...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2365-9
更新日期:2013-02-01 00:00:00
abstract::The aim of the study was to estimate the annual direct costs of biological therapies in rheumatoid arthritis (RA), and to establish possible factors associated with those costs. The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry). We included patients with avai...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04762-7
更新日期:2021-01-02 00:00:00
abstract::Meigs' syndrome represents a triad of pleural effusion, ascites, and an ovarian tumor, usually benign, occurring together. We describe here a case of Meigs' syndrome in a patient with systemic sclerosis, the first such report to our knowledge, in systemic sclerosis. A 53-year-old woman with systemic sclerosis presente...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2437-x
更新日期:2013-10-01 00:00:00
abstract::To establish whether a cadaver model can serve as an effective surrogate for the detection of tendon damage characteristic of rheumatoid arthritis (RA). In addition, we evaluated intraobserver and interobserver agreement in the grading of RA-like tendon tears shown by US, as well as the concordance between the US find...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3460-0
更新日期:2016-06-01 00:00:00
abstract::Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541597
更新日期:1983-01-01 00:00:00
abstract::The objective of the study was to assess the ESSDAI index characteristics in the SJÖGRENSER cohort (Spanish Rheumatology Association's registry of patients with Primary Sjögren Syndrome [PSS]). SJÖGRENSER is a prospective multicentric study on a cohort of Spanish patients with PSS who meet the 2002 American-European c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04285-w
更新日期:2019-06-01 00:00:00
abstract::A 56-year-old woman presented with changes characteristic of the reflex sympathetic dystrophy syndrome (RSDS) but also frank synovitis of the left wrist, an elevated ESR and early damage of the left carpus on radiographs, suggesting septic arthritis. A dynamic scan showed changes characteristic of RSDS. A sample of sy...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541334
更新日期:1985-01-01 00:00:00
abstract::Polyarteritis nodosa (PAN) related to hepatitis B is an uncommon vasculitis that is sometimes associated with the rapid progression of distal ischemia. A few recent reports have proposed the use of antiviral therapy. However, there is not yet a consensus for the standard treatment of this disease entity and none of th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0103-x
更新日期:2006-08-01 00:00:00
abstract::Anti-TNF drugs may increase lymphoma risk in autoimmune rheumatic diseases, such as rheumatoid arthritis, but there have been no reports stating increased risk of lymphoma in ankylosing spondylitis (AS). Before 2 years, we had presented a case with AS developing Hodgkin's lymphoma following 6 months of etanercept trea...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1265-0
更新日期:2011-12-01 00:00:00