Abstract：
:The aim of the study was to estimate the annual direct costs of biological therapies in rheumatoid arthritis (RA), and to establish possible factors associated with those costs. The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry). We included patients with available 1-year data. Variables related to socio-economic status, disease and biological therapy were collected. Direct costs included prices of biologics, costs of infusions, and subcutaneous injections. Differences in costs across groups were tested by Mann-Whitney and Kruskal-Wallis tests. Correlations analysis was performed in search of factors associated with high costs. We included 197 rheumatoid arthritis patients. The mean age was 52.3 ± 11 years, with female predominance 86.8%. Receiving one of the following therapies: rituximab (n = 132), tocilizumab (n = 37), or TNF-blockers (n = 28). Median one-year direct costs per patient were €1665 [€1472-€9879]. The total annual direct costs were € 978,494. Rituximab, constituted 25.7% of the total annual budget. TNF-blockers and tocilizumab represented 27.3% and 47% of this overall budget, respectively. Although the costs were not significantly different in terms of gender or level of study, the insurance type significantly affected the cost estimation. A positive correlation was found between the annual direct cost and body mass index (r = 0.15, p = 0.04). In Morocco, a developing country, the annual direct costs of biological therapy are high. Our results may contribute to the development of strategies for better governance of these costs.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Fellous S,Rkain H,Ahid S,Abouqal R,Tahiri L,Hmamouchi I,Achemlal L,El Bouchti I,El Maghraoui A,Ghozlani I,Hassikou H,Harzy T,Ichchou L,Mkinsi O,Niamane R,Bahiri R,Allali Fdoi
10.1007/s00296-020-04762-7subject
Has Abstractpub_date
2021-01-02 00:00:00eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-020-04762-7pub_type
杂志文章abstract：:Osteomyelitis variolosa is an osteoarticular complication of small pox infection. We are presenting a case of osteomyelitis variolosa, who presented to us with fracture of ankle on the involved side with other orthopedic sequelae of small pox infection, which he contracted during his childhood period. We have discusse...
journal_title：Rheumatology international
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
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journal_title：Rheumatology international
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
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pub_type： 信件
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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pub_type： 杂志文章
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