Abstract：
:Several molecular epidemiological studies have been conducted in recent years to evaluate a possible association between the interferon regulatory factor 5 (IRF5) rs2004640 polymorphism and rheumatoid arthritis risk in diverse populations. However, the results remain conflicting rather than conclusive. Our aim was to assess associations of IRF5 gene polymorphisms with rheumatoid arthritis risk. Meta-analysis was performed on six published case-control studies (from eight countries) that included 4,818 cases of rheumatoid arthritis and 4,316 controls. The rs2004640-T allele was associated with a significantly increased risk of rheumatoid arthritis when the dominant genetic model was applied (T/T + T/G versus G/G: P = 0.003, OR = 1.14, 95% CI 1.05-1.25). Upon stratified analysis by ethnicity, the rs2004640 polymorphism was associated with an increased rheumatoid arthritis risk in Caucasians when the homozygotic contrast model was employed(T/T versus G/G: P = 0.03, OR = 1.25, 95% CI 1.02-1.53) and this was also the case when the dominant genetic model was used (T/T + T/G versus G/G: P = 0.04, OR = 1.20, 95% CI 1.01-1.42), whereas, in Asian populations, only the dominant genetic model was associated with an increased rheumatoid arthritis risk (T/T + T/G versus G/G: P = 0.02, OR = 1.14, 95% CI 1.02-1.26). The results suggest that the IRF5 rs2004640 polymorphism is associated with rheumatoid arthritis especially when the dominant genetic model is applied.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Jia X,Hu M,Lin Q,Ren Hdoi
10.1007/s00296-013-2806-0subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2757-61issue
11eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章,meta分析abstract：:Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541153
更新日期：1981-01-01 00:00:00
abstract：:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatological conditions that are characterized by mucosal erosions, epidermal detachments and erosions. The most common causes of SJS and TEN are drugs; other causes such as systemic lupus erythematosus (SLE), vaccinations and i...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3677-6
更新日期：2017-07-01 00:00:00
abstract：:We assess the usefulness of 99mTc-pertechnetate hand perfusion scintigraphy in patients with Raynaud's phenomenon (RP). The study population consisted of 18 patients with primary RP, 25 patients with secondary RP within systemic sclerosis (SSc), and ten healthy individuals. Gamma camera dynamic first-pass study during...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3584-2
更新日期：2016-12-01 00:00:00
abstract：:Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side ef...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04588-3
更新日期：2020-07-01 00:00:00
abstract：:Intraperitoneal injection of pristane induced a clinical peripheral arthritis and/or tenosynovitis in 40% of 40 Balb/cJ/Ola mice. Hind paws were always affected first and fore paws were frequently involved. Involvement of knee joints was only apparent histologically. Some clinically unaffected animals and apparently u...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541361
更新日期：1984-01-01 00:00:00
abstract：:Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease but it has been found in many other autoimmune diseases like systemic lupus erythematosus (SLE). Furthermore, cross-reactive epitopes on β2-glycoprotein I (β2GPI) and Saccharomyces cerevisiae were found in SLE patients. T...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2431-3
更新日期：2013-03-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic, progressive, debilitating disease that demands continuous therapy with multiple medications. Noncompliance with disease-modifying drugs may cause disease flares, preventable functional impairment, unnecessary treatment changes, and loss of health care resources. The aim of the c...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2162-x
更新日期：2012-10-01 00:00:00
abstract：:Protein synthesis in all cells is readily interrupted by environmental stresses such as hyperthermia. However, stressed cells also have mechanisms which, even under conditions where normal protein synthesis is completely inhibited, allow them to synthesise a group of highly conserved proteins--the so-called heat shock...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/BF00541323
更新日期：1990-01-01 00:00:00
abstract：:Microscopic polyangiitis is a small-vessel necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies and presents itself with glomerulonephritis and hemorrhagic pulmonary capillaritis. Peripheral nervous system involvement is common in anti-neutrophil cytoplasmic antibodies-associated vasculitis, b...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-016-3424-4
更新日期：2016-07-01 00:00:00
abstract：:To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-4150-x
更新日期：2018-12-01 00:00:00
abstract：:The objective of the study is to investigate the clinical characteristics and long-term prognosis including flares and organ damage in patients with giant cell arteritis (GCA) from a tertiary referral centre and compare these features in different subgroups. In this retrospective observational study, patients with GCA...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04730-1
更新日期：2021-02-01 00:00:00
abstract：:Dissemination of research studies is important for research ideas to be transformed from initial abstracts to full publications. Analyses of the scientific impact and publication record of the Canadian Rheumatology Association (CRA) Annual meeting have not been previously described. This study determines the publicati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3701-x
更新日期：2017-06-01 00:00:00
abstract：:The objectives of the study were to evaluate the prevalence of antinuclear antibodies (ANA) in patients with fibromyalgia (FM) and the probability of the development of clinically overt connective tissue diseases. Four hundred and fifty FM patients were compared to 129 healthy matched blood donors. ANA testing was per...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0413-7
更新日期：2007-09-01 00:00:00
abstract：:Our aim was to investigate the relationship between the DNA methylation status of glucocorticoid receptor (GR) gene promoter and mRNA expression level of GRα gene of peripheral blood mononuclear cells (PBMCs) in patients with systemic lupus erythematosus (SLE). Fifteen newly emerging SLE patients and fifteen healthy c...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3266-5
更新日期：2015-08-01 00:00:00
abstract：:When rheumatoid articular cartilage samples were incubated with normal peripheral blood monocytes and cultured synovial cells in the presence of recombinant human interleukin-1 (IL-1) in vitro, large numbers of monocytes were seen to be attached to the articular surface. Significant numbers of monocytes invaded the ca...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00290248
更新日期：1991-01-01 00:00:00
abstract：:To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2463-8
更新日期：2013-04-01 00:00:00
abstract：:Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270349
更新日期：1986-01-01 00:00:00
abstract：:Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-1145-7
更新日期：2011-01-01 00:00:00
abstract：:The risk of herpes zoster among patients with juvenile idiopathic arthritis (JIA) exposed to biologics has not been evaluated. We determined incidence rates of herpes zoster among children with JIA in correlation with medication at time of occurrence and total drug exposure. The German biologics register database was ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3197-6
更新日期：2015-03-01 00:00:00
abstract：:The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report results of the cross-cultural adaptation and validation of the parent and patient v...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-3969-5
更新日期：2018-04-01 00:00:00
abstract：:Tuberculosis can affect sacroiliac joints, but only a few such cases have been reported. The onset is usually insidious, and early diagnosis requires a high index of clinical suspicion. We report herein a culture-proven case of tuberculous sacroiliitis which initially mimicked neoplastic infiltration on CT scan. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0406-0
更新日期：2004-09-01 00:00:00
abstract：:To compare oxidative stress (OS) biomarkers and antioxidant capacity of plasma (ACP) between dcSSc (diffuse cutaneous systemic sclerosis) and healthy Mexicans and their possible relationship with autoantibodies, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid (UA). We included 28 dcSSc an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2701-8
更新日期：2013-09-01 00:00:00
abstract：:Solid organ transplantation is an important lifesaving procedure mainly performed in patients with end-stage organ failure such as liver cirrhosis, congestive heart failure, and end-stage renal disease. While these complications are among the most preventable adverse effects of solid organ transplantation, these are g...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1970-3
更新日期：2012-08-01 00:00:00
abstract：:Thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP) is a rare but potentially lethal condition requiring rapid recognition, diagnosis, and initiation of therapy. We experienced a case of a 61-year-old woman with primary Sjögren's syndrome (pSS) complicated with severe renal TMA/TTP following IgM...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1569-0
更新日期：2013-01-01 00:00:00
abstract：:A community-based cohort comprising 150 patients with recent-onset seropositive arthritis or seronegative oligoarthritis or polyarthritis was monitored for 8 years. Of the different rheumatoid factor (RF) tests, the initial positivity in the most sensitive assays (latex slide test and IgM-RF by enzyme immunoassay) was...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541346
更新日期：1988-01-01 00:00:00
abstract：:To examine messages perceived by members of an osteoporosis (OP) patient group from various healthcare providers regarding bone health. We conducted a phenomenological (qualitative) study in members of an OP patient group who resided in Canada, had sustained a fragility fracture at 50+ years old, and were not taking a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3079-y
更新日期：2015-01-01 00:00:00
abstract：:The aim of the study was the thermovisual comparison of mean temperature of hand surface changes after local cryotherapy with vapors of nitrogen (-160°C) and cold air (-30°C). Forty-seven patients with rheumatoid arthritis (39 women and 8 men; average age 56.2 ± 10.5 years) were included in the study. They had the app...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-011-2078-5
更新日期：2012-10-01 00:00:00
abstract：:In a randomized multicenter, double-blind, double-dummy, parallel group study a comparison of the efficacy and safety of 1 microg alfacalcidol to 880 IU vitamin D plus calcium carbonate (1 g calcium) once daily per os was performed on 148 postmenopausal osteoporotic Caucasian patients with normal vitamin D serum level...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00296-005-0073-4
更新日期：2006-03-01 00:00:00
abstract：:Osteopoikilosis, a form of osteosclerotic disorders, is a rare bone dysplasia with typical radiologic findings. The pathology, which sometimes requires attention in differential diagnosis due to its radiologic appearance, has been reported previously with other diseases. In this report, a case diagnosed with both reac...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0037-8
更新日期：2006-05-01 00:00:00
abstract：:The exact elucidation of skeletal and cartilagineous involvement in neonatal-onset multisystem inflammatory disease (NOMID) is still poorly known, and there are few data providing the long-term response to treatment with the available interleukin-1 inhibitors. We present here a 13-year-old boy with NOMID treated with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1787-5
更新日期：2011-12-01 00:00:00
