Abstract：
:A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were 4-week, double-blind, randomized, parallel-group comparisons of etodolac SR 600 mg (119 patients) against diclofenac SR 100 mg (54 patients), tenoxicam 20 mg (46 patients), or piroxicam 20 mg (18 patients). The primary efficacy parameters (assessed after 2 and 4 weeks of treatment) were physicians' and patients' overall assessments of patients' condition, night pain, and pain intensity. All patients had radiographic and clinical evidence of OA of the knee. For the meta-analysis, the data from the individual etodolac SR studies were pooled and compared with the pooled data for diclofenac SR, tenoxicam, and piroxicam. The homogeneity of the treatments across studies and the changes from baseline between groups were tested using a Cochran-Mantel-Haenszel test and an analysis of variance, including "study," "treatment," and "center within treatment" effects and their interaction. The analysis for the efficacy parameters was based on the final assessment during therapy (last visit). At baseline, the two treatment groups were comparable. Improvement rates were high in both groups (range, 68-81%), indicating that treatments were effective for most patients. No significant treatment difference was observed for the patients' overall assessment, night pain, or pain intensity. Both etodolac SR and the reference preparations were well tolerated. No clinically significant changes were noted in the laboratory data.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Porzio Fdoi
10.1007/BF00290280subject
Has Abstractpub_date
1993-01-01 00:00:00pages
S19-24issue
2 Suppleissn
0172-8172issn
1437-160Xjournal_volume
13pub_type
杂志文章,meta分析abstract：:The objectives of the study were to evaluate the prevalence of antinuclear antibodies (ANA) in patients with fibromyalgia (FM) and the probability of the development of clinically overt connective tissue diseases. Four hundred and fifty FM patients were compared to 129 healthy matched blood donors. ANA testing was per...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0413-7
更新日期：2007-09-01 00:00:00
abstract：:Some infectious, rheumatic, allergic diseases, and malignancies have been associated with leucocytoclastic vasculitis (LCV). LCV and cancer occur most frequently in patients with hematological malignancies such as lymphomas and leukemias. There have been a few prior cases reported of LCV associated with renal cell car...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1063-8
更新日期：2010-08-01 00:00:00
abstract：:We have prepared antibody/3H-dsDNA immune complexes and have used three independent radioimmunoassays to quantitate their interaction with complement; the solution phase C1q assay, the Raji cell assay, and a complement-based red blood cell adherence assay (RBC-CF). Our results indicate that although there is reasonabl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541220
更新日期：1981-01-01 00:00:00
abstract：:Ultrasonography (US) and power Doppler sonography (PDS) was used to investigate causes of new onset of shoulder pain and sites of shoulder inflammation in 157 shoulders of 99 patients with rheumatoid arthritis (RA). US detected effusion and/or synovitis in 92/157 glenohumeral joints, subdeltoid bursitis in 56/157 shou...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0465-8
更新日期：2008-03-01 00:00:00
abstract：:The objective of this study is to describe the interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients of China, and to study clinical significance of high-resolution computed tomography (HRCT) in evaluation and treatment. One hundred and ten Chinese patients (79 women and 31 man) diagnosed with RA betwe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1665-1
更新日期：2012-03-01 00:00:00
abstract：:CD4(+) T cells from patients with systemic lupus erythematosus (SLE) exhibit increased expression of various proteins contributing to defective function of CD4(+) T cells. We evaluated the transcript and protein levels of perforin (PRF1) in CD4(+) T cells from SLE patients (n = 41) and healthy individuals (n = 34). Th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1329-1
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVES:To identify recommendations on the diagnosis and management of rheumatoid arthritis (RA) supported by low recommendation grades, to study the causes of this low grading, and to propose solutions. METHODS:A group of six rheumatologists, with extensive experience in the development of systematic reviews, revi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04724-z
更新日期：2021-01-01 00:00:00
abstract：:Severe vaso-occlusive retinopathy is a relatively rare form of retinopathy in systemic lupus erythematosus (SLE). We report two patients with severe vaso-occlusive retinopathy in SLE who were treated with intravitreal bevacizumab (IVB). (Patient 1) A 35-year-old woman presented with left visual loss and was diagnosed ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2139-9
更新日期：2013-01-01 00:00:00
abstract：:Behçet's disease (BD) commonly presents with articular manifestations and thrombotic vasculopathy. Arthritis of BD characteristically demonstrates a recurrent and nondestructive course. The pathobiological basis of the thrombotic vasculopathy and protective factors against cartilage destruction in arthritis of BD have...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0324-1
更新日期：2004-03-01 00:00:00
abstract：:While carpal tunnel syndrome (CTS) is the most common entrapment neuropathy presented at rheumatologic consultation, its ulcerative variant is rarely described. We report of a case of severe bilateral medial nerve palsy, presented to us for diagnosis of chronic digital ulcers which had been suspected to be rheumatolog...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1229-4
更新日期：2011-05-01 00:00:00
abstract：:Malignant neoplasms are associated with a wide variety of paraneoplastic rheumatological syndromes. The paraneoplastic nature should be based on specific criteria. We report a series of eight cases of paraneoplastic rheumatic syndromes revealing an underlying neoplasia. Our series consists of six men and two women, wi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2252-9
更新日期：2012-06-01 00:00:00
abstract：:Infliximab, a monoclonal chimeric anti-tumor necrosis factor alpha (anti-TNF-alpha) antibody, was tried in two patients suffering from severe refractory juvenile ankylosing spondylarthritis with disease duration of more than 10 years. To assess the response, validated clinical activity parameters were monitored prospe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0378-0
更新日期：2004-05-01 00:00:00
abstract：:The purpose of this study was to demonstrate the direct effects of celecoxib, one of the selective cyclo-oxygenase (COX)-2 inhibitors, on nitric oxide (NO) and prostaglandinE2 (PGE2) synthesis in cultured osteoarthritic chondrocyte comparing with those of indomethacin. Articular chondrocytes were isolated from rat ost...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0107-6
更新日期：2006-09-01 00:00:00
abstract：:Macrophage activation syndrome (MAS) is a hyper-inflammatory disorder secondary to a rheumatic disease such as systemic juvenile idiopathic arthritis (SJIA) and systemic lupus erythematosus (SLE). We aimed to present the characteristics of our pediatric MAS patients. Clinical features, laboratory parameters, treatment...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3545-9
更新日期：2016-10-01 00:00:00
abstract：:We measured alpha 2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P less than 0.001) and the SLE patients wi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270984
更新日期：1989-01-01 00:00:00
abstract：:The FRAX tool that calculates the 10-year probability of having a fracture has recently been validated for Belgium. Little is known about the perception and knowledge that GPs have about this tool in their daily practice. A survey has been conducted as part of a screening campaign for various diseases. The primary obj...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2461-x
更新日期：2013-04-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) affects women of childbearing age. To optimize fetal and maternal outcomes, effective reproductive health counseling is crucial. To analyze the effectiveness of reproductive health counseling in women with SLE and identify gaps in patient educational needs. Cross-sectional study incl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04671-9
更新日期：2021-02-01 00:00:00
abstract：:In a prospective study 222 sera from 56 patients with systemic lupus erythematosus (SLE) were tested for antibodies to poly(A), poly dAT and histones using enzyme-linked immunosorbent assay (ELISA). Patients with active disease had significantly more often antibodies to poly(A), poly dAT and histones than patients wit...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541200
更新日期：1984-01-01 00:00:00
abstract：:We sought to determine the prevalence of additional connective tissue diseases (CTDs) in patients with idiopathic inflammatory myopathies (IIM), and to study the muscle biopsy patterns in various clinico-serologic subsets of myositis. We undertook a retrospective cohort study of 648 patients with a histological diagno...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04411-8
更新日期：2019-10-01 00:00:00
abstract：:Diagnostic accuracy of anti-DNase I antibodies measurement in a differentiation between SLE and other autoimmune rheumatic diseases was evaluated. The share of anti-DNase I and actin in the DNase I activity decrease in SLE was established. Serum samples were obtained from 54 patients with verified SLE, 52 control pati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3437-z
更新日期：2016-04-01 00:00:00
abstract：:A 44-year-old man with intermittent asymmetric migratory oligoarthritis lasting the recent decade was admitted to our hospital. Considerable specific biomarkers for rheumatoid arthritis such as anti-agalactosyl IgG antibody are all negative. He was diagnosed as palindromic rheumatism (PR). Although hand X-rays showed ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0654-0
更新日期：2008-11-01 00:00:00
abstract：:Osteoporosis has become an increasingly recognized complication among patients with chronic liver disease (CLD). The aim of the present study was to assess the prevalence and risk factors of osteoporosis in patients with CLD (primary biliary cirrhosis and chronic viral hepatitis B or C patients) in comparison with a g...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1071-8
更新日期：2010-05-01 00:00:00
abstract：:To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological gui...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3201-1
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to measure serum oxidized low-density lipoprotein (Ox-LDL) levels in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and to identify any association with clinical variables. METHODS:We studied 126 female patients (27 with active RA, 27 with inactive RA,...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0358-4
更新日期：2004-07-01 00:00:00
abstract：:We determined whether repeated treatment with the tumor necrosis factor-α (TNF-α) antagonist etanercept can be effective after an initial clinical response to this drug is lost. We describe three female patients with active, refractory rheumatoid arthritis who were administered with a second course of etanercept after...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2124-3
更新日期：2012-11-01 00:00:00
abstract：:Serotonin antagonists show impressive analgesic efficacy in rheumatoid arthritis, osteoarthritis (OA) or fibromyalgia; however, this effect is not well understood. We examined the mechanism of serotonin-induced inflammation and its antagonists in OA. Serotonin receptor subtypes and COX-2 were analysed by RT-PCR from s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0564-1
更新日期：2008-08-01 00:00:00
abstract：:A 45-year-old female presented to the rheumatology clinic with complaint of pain and swelling of multiple small joints of the hands and feet. She also complained of cough and shortness of breath onset around the same time. Since her cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor tests were posi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-1294-8
更新日期：2011-12-01 00:00:00
abstract：:Osteoarthritis (OA) is a multifactorial degenerative pathology, whose progression is exacerbated by pro-inflammatory cytokines signaling. Among the changes triggered in chondrocytes during inflammation, modified expression of tiny epigenetic regulators as microRNAs was shown having deleterious implications for articul...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2754-8
更新日期：2014-05-01 00:00:00
abstract：:GPA with pituitary involvement is a rare condition which is prone to be misdiagnosed. The aim of this study was to summarize clinical features of pituitary involvement in GPA and facilitate early diagnosis. Twelve GPA patients were retrospectively analyzed at a single hospital between 2000 and 2017. A literature revie...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04338-0
更新日期：2019-08-01 00:00:00
abstract：:Individual differences in adjustment during a disease's course determine psychological response and outcome. This study aimed to investigate prospectively whether coping with health stressors and self-sacrificing defense style could predict psychological adjustment and health-related quality of life (HRQoL) in patient...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3134-8
更新日期：2015-04-01 00:00:00
