Abstract:
:The objectives of the study were to evaluate the prevalence of antinuclear antibodies (ANA) in patients with fibromyalgia (FM) and the probability of the development of clinically overt connective tissue diseases. Four hundred and fifty FM patients were compared to 129 healthy matched blood donors. ANA testing was performed by immunofluorescence on rat tissue sections; in case of highly positive results, ANA were specified further by ELISA and immunodiffusion. All ANA positive FM patients were invited for a control examination. The ANA negative patients received a questionnaire, which was designed to identify those patients with possible connective tissue diseases (CTD). There was no significant difference in the frequency of ANA or thyroid antibodies between patients and controls (11.6% vs. 7%). Two patients had developed SLE: one was already ANA/anti-dsDNA positive at time of first diagnosis of FM; in the other, specific antibodies and SLE-related symptoms developed after 4.5 years. The probability for FM patients to develop CTD (SLE) within one year is 0.0027%, which is comparable to the incidence of SLE in the general population (0.005%). The risk of CTD is not increased in FM. The detection of ANA does not predict the development of CTD. However, in individual cases, FM may be an early sign of an autoimmune disease.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kötter I,Neuscheler D,Günaydin I,Wernet D,Klein Rdoi
10.1007/s00296-007-0413-7subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1031-9issue
11eissn
0172-8172issn
1437-160Xjournal_volume
27pub_type
杂志文章abstract::Fibromyalgia (FM) is the most common chronic pain syndrome encountered in medical practice, affecting females more than males, and the estimated prevalence of FM in Egypt is 1.3 %. The aim was to translate and adapt the Fibromyalgia Impact Questionnaire (FIQ) into Arabic and assess reliability and validity. The Arabic...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2779-z
更新日期:2013-10-01 00:00:00
abstract::The aim of this study was to investigate the frequency of patients with rheumatoid arthritis (RA) who have inflammatory back pain (IBP) and meet the existing classification criteria for ankylosing spondylitis (AS) and spondyloarthritis (SpA). We included 167 patients fulfilling the ACR 1987 revised criteria for RA. Af...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2553-7
更新日期:2013-05-01 00:00:00
abstract::To assess the prognostic value of scleroderma pattern of nailfold capillary changes for the development of connective tissue diseases (CTD) in subjects with primary Raynaud's phenomenon (RP). The study included 3,029 consecutive patients with primary RP who had been followed at 6-month intervals during the mean of 4.8...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2109-2
更新日期:2012-10-01 00:00:00
abstract::Severe vaso-occlusive retinopathy is a relatively rare form of retinopathy in systemic lupus erythematosus (SLE). We report two patients with severe vaso-occlusive retinopathy in SLE who were treated with intravitreal bevacizumab (IVB). (Patient 1) A 35-year-old woman presented with left visual loss and was diagnosed ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2139-9
更新日期:2013-01-01 00:00:00
abstract::To evaluate serum levels of IL6 in patients with Kawasaki disease and compare it with CRP, and to assess the role of these biomarkers in predicting coronary changes and resistance to the first-line therapy of this disease in a subset of Indian population. A single centre prospective observational study was conducted a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04375-9
更新日期:2019-10-01 00:00:00
abstract::To examine messages perceived by members of an osteoporosis (OP) patient group from various healthcare providers regarding bone health. We conducted a phenomenological (qualitative) study in members of an OP patient group who resided in Canada, had sustained a fragility fracture at 50+ years old, and were not taking a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3079-y
更新日期:2015-01-01 00:00:00
abstract::The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evid...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541376
更新日期:1987-01-01 00:00:00
abstract::The aim of the study was to compare the diagnostic efficacy of the visual assessment of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) sequences compared to the STIR sequence in the diagnostics of active sacroiliitis in the course of axial spondyloarthritis (axSpA). The study group consisted of 4...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04373-x
更新日期:2019-09-01 00:00:00
abstract::3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301776
更新日期:1995-01-01 00:00:00
abstract::Arthrocutaneous disorders including Reiter's syndrome, psoriasiform rashes, and other forms of chronic arthritis and enthesopathy, such as psoriatic arthritis, occur with an increased prevalence in the setting of HIV infection. Herein we describe the spectrum and prevalence of musculoskeletal and allied skin disorders...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/BF00271870
更新日期:1989-01-01 00:00:00
abstract::The aim of this study was to compare the efficacy of sodium hyaluronate (SH) injection with the most common treatment methods, intraarticular steroid injection and physical therapy modalities in patients with adhesive capsulitis (AC). A total of 95 shoulders of 90 patients were included in the study and were randomize...
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-005-0022-2
更新日期:2006-04-01 00:00:00
abstract::Neopterin levels of serum and fluid were determined in 30 patients with inflammatory synovial fluids and in 30 controls with joint effusions induced by trauma or osteoarthritis. Neopterin was significantly elevated in inflammatory fluids. There was no correlation with the acute phase reactants. Neopterin levels were s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541281
更新日期:1986-01-01 00:00:00
abstract::Adult-onset Still's disease (AOSD) is known as a systemic inflammatory disease of unknown etiology and pathogenesis, characterized by fever, skin eruptions, systemic organ involvement, and arthralgias. AOSD is difficult to diagnose because of its heterogeneous clinical manifestations and prevalence (although more prev...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1991-y
更新日期:2012-08-01 00:00:00
abstract::A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04414-5
更新日期:2019-12-01 00:00:00
abstract::Leg ulcers are a manifestation of antiphospholipid syndrome (APS), and characteristically respond poorly to treatment. Because the similar findings both clinical and pathological to pyoderma gangrenosum (PG), we treated these patients with a combination of immunosuppression (steroids, azathioprine or cyclosporine), ac...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1418-1
更新日期:2010-07-01 00:00:00
abstract::Spondyloarthropathy refers to any joint disease of the vertebral column, but the term is mainly used for a specific group of disorders called seronegative spondyloarthropathies (SpAs). The axial skeletal involvement, peripheral and extra-articular manifestations and an association with the major histocompatibility com...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04346-0
更新日期:2019-09-01 00:00:00
abstract::Takayasu arteritis (TA) is a rare autoimmune disease of unknown etiology. Genome-wide association studies (GWAS) have demonstrated association between genetic variants of IL12B and IL6 and TA. Since TA has been reported with ethnic heterogeneity, we sought to investigate whether the single-nucleotide-polymorphisms (SN...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-016-3648-3
更新日期:2017-04-01 00:00:00
abstract::Routine assessment of patient index data 3 (RAPID3) is a simple, valid and reliable tool designed to measure disease activity in patients with rheumatoid arthritis (RA). RA causes significant disability and diminishes health-related quality of life (HR-QoL). The aim of this study was to investigate how RAPID3 is relat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04258-z
更新日期:2019-05-01 00:00:00
abstract::Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04689-z
更新日期:2021-02-01 00:00:00
abstract::The aim of this study was to identify the possible determinants of impaired health-related quality of life (HRQOL) in Egyptian children and adolescents with juvenile idiopathic arthritis (JIA). Fifty-eight consecutive patients of JIA aged from 8 to 18 years underwent assessment of socio-economic and demographic charac...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-2950-1
更新日期:2014-08-01 00:00:00
abstract::Chondrocyte structure and function under the influence of two gold-containing therapeutic agents, aurothioglucose and triethylphosphine gold, were studied in a monolayer culture system for cultivating lapine articular chondrocytes. The functional parameters investigated were chondrocyte proliferation and the incorpora...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541144
更新日期:1983-01-01 00:00:00
abstract::We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960000054
更新日期:2000-01-01 00:00:00
abstract::Rickettsia rickettsii, a tick borne disease, is the pathogen responsible for inducing Rocky Mountain Spotted Fever (RMSF), an illness that can progress to fulminant multiorgan failure and death. We present a case where R. rickettsii, acquired on a camping trip, precipitated a flare of peripheral arthritis and episcler...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04330-8
更新日期:2019-09-01 00:00:00
abstract::Malignant neoplasms are associated with a wide variety of paraneoplastic rheumatological syndromes. The paraneoplastic nature should be based on specific criteria. We report a series of eight cases of paraneoplastic rheumatic syndromes revealing an underlying neoplasia. Our series consists of six men and two women, wi...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-011-2252-9
更新日期:2012-06-01 00:00:00
abstract::PADI4 that catalyzes the conversion of peptidylarginine to citrulline is associated with rheumatoid arthritis in some populations. The current study investigated the expressions of PADI4 in synovial fluid of RA (n = 73), osteoarthritis (OA, n = 96) and ankylosing spondylitis (AS, n = 32) using ELISA and western blotti...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0870-2
更新日期:2009-10-01 00:00:00
abstract::The Fc receptor-like (FCRL) molecules have recently been shown to contribute to the pathogenesis of certain autoimmune disorders. In this study, we investigated the expression levels of FCRL1, 2 and 4 in blood mononuclear cells from rheumatoid arthritis patients using real-time PCR. The mRNA of these molecules was det...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3495-2
更新日期:2016-08-01 00:00:00
abstract::Fibromyalgia syndrome is characterized by chronic generalized pain accompanied by a broad symptomatologic spectrum. Besides chronic fatigue, sleep disturbances, headaches and cognitive dysfunction that are extensively described in the literature, a considerable proportion of patients with fibromyalgia experience gastr...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-014-3109-9
更新日期:2015-03-01 00:00:00
abstract::Familial Mediterranean fever is characterized by self-limited attacks of serositis and arthritis. However, substantial number of patients suffer from chronic complications of this disease, primarily involving musculoskeletal system. Treatment for these complications is challenging due to limited evidence. Interleukin-...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04490-7
更新日期:2020-01-01 00:00:00
abstract::To describe the characteristics of patients receiving belimumab, overall patterns of systemic lupus erythematosus (SLE) care, clinical outcomes, and changes in glucocorticoid dose following 6 months of therapy with belimumab, and healthcare resource utilization in belimumab users in Canadian clinical practice settings...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-017-3682-9
更新日期:2017-06-01 00:00:00
abstract::The objectives of this study are to evaluate the prevalence of radiographic hand osteoarthritis (OA) in Chuvashian community-based sample and its associations with age, sex, body mass index (BMI), smoking, and alcohol consumption. The study population was comprised of Chuvashians (443 males, age 47.4 ± 17.0 years and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0920-9
更新日期:2009-11-01 00:00:00