A comparison of the effects of two gold-containing therapeutic agents on articular chondrocyte growth in vitro.


:Chondrocyte structure and function under the influence of two gold-containing therapeutic agents, aurothioglucose and triethylphosphine gold, were studied in a monolayer culture system for cultivating lapine articular chondrocytes. The functional parameters investigated were chondrocyte proliferation and the incorporation of 35SO4 as indicator of glycosaminoglycan synthesis. Aurothioglucose (0.2, 1 and 10 micrograms/ml) failed to affect either parameter and caused no cytotoxic effect detectable with the light microscope. Triethylphosphine gold (1.5 and 3 micrograms/ml) prevented subcultured chondrocytes from forming monolayers and was cytotoxic to chondrocytes present in established monolayers, studied with the light and scanning electron microscope. A 0.3 microgram/ml concentration did not alter chondrocyte proliferation or sulphate incorporation and was not cytotoxic.


Rheumatol Int


Kirkpatrick CJ,Mohr W




Has Abstract


1983-01-01 00:00:00












  • Temperature changes in rheumatoid hand treated with nitrogen vapors and cold air.

    abstract::The aim of the study was the thermovisual comparison of mean temperature of hand surface changes after local cryotherapy with vapors of nitrogen (-160°C) and cold air (-30°C). Forty-seven patients with rheumatoid arthritis (39 women and 8 men; average age 56.2 ± 10.5 years) were included in the study. They had the app...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章


    authors: Korman P,Straburzyńska-Lupa A,Romanowski W,Trafarski A

    更新日期:2012-10-01 00:00:00

  • Drug-induced lupus in anti-TNF-alpha therapy and its treatment with rituximab.

    abstract::We report three patients with rheumatoid arthritis (RA) who were treated with anti-TNF-α agents and who developed drug-induced lupus (DIL). Two of them received etanercept and the remainder adalimumab. We also present the favorable response observed with the withdrawal of the anti-TNF-alpha agents and the introduction...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Diaz JC,Vallejo S,Cañas CA

    更新日期:2012-10-01 00:00:00

  • Infliximab in two patients with juvenile ankylosing spondylitis.

    abstract::Infliximab, a monoclonal chimeric anti-tumor necrosis factor alpha (anti-TNF-alpha) antibody, was tried in two patients suffering from severe refractory juvenile ankylosing spondylarthritis with disease duration of more than 10 years. To assess the response, validated clinical activity parameters were monitored prospe...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Schmeling H,Horneff G

    更新日期:2004-05-01 00:00:00

  • Association of the IRF5 rs2004640 polymorphism with rheumatoid arthritis: a meta-analysis.

    abstract::Several molecular epidemiological studies have been conducted in recent years to evaluate a possible association between the interferon regulatory factor 5 (IRF5) rs2004640 polymorphism and rheumatoid arthritis risk in diverse populations. However, the results remain conflicting rather than conclusive. Our aim was to ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,meta分析


    authors: Jia X,Hu M,Lin Q,Ren H

    更新日期:2013-11-01 00:00:00

  • Ultrastructural characterisation of macrophages (type A cells) in the synovial lining.

    abstract::The ultrastructural localisation of class II and macrophage antigens has been sought in the intimal layer of the human synovium. The cells described as type A in early morphological studies are shown to express both class II antigens and two markers of the macrophage/monocyte lineage of cells, OKM1 and MAB 24. The mor...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Mapp PI,Revell PA

    更新日期:1988-01-01 00:00:00

  • Factors associated with the accuracy of self-reported osteoporosis in the community.

    abstract::We examined the agreement between self-reported osteoporosis and bone mineral density (BMD) results through dual-energy x-ray absorptiometry (DXA) using data from a national representative sample taken from the US communities. Six-year data from the continuous National Health and Nutrition Examination Survey 2005-2006...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Cunningham TD,DeShields SC

    更新日期:2016-12-01 00:00:00

  • Development and validation of SCAISS, a tool for semi-automated quantification of sacroilitis by magnetic resonance in spondyloarthritis.

    abstract::To develop a semi-automated method to quantify inflammation in sacroiliac (SI) joints by measuring bone marrow edema (BME) on MRI. The SCAISS was designed as an image-processing software. Validation followed: (1) three readers evaluated SI images of 23 patients with axial SpA and various levels of BME severity with th...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Zarco P,Almodóvar R,Bueno Á,Molinero LM,SCAISS Study Group.

    更新日期:2018-10-01 00:00:00

  • Bullous lupus erythematosus in a patient with pre-existing dermatomyositis.

    abstract::The group of autoimmune cutaneous connective tissue diseases (CCTD) includes systemic sclerosis, dermatomyositis (DM), lupus erythematosus (LE), and subtypes. Most CCTD patients can be assigned to one of these phenotypes or mixed forms, and transitions among the subsets exist. We present the case of a 26-year-old woma...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Wenzel J,Bokemeyer D,Wilsmann D,Gerdsen R,Tueting T,Uerlich M,Bieber T

    更新日期:2004-03-01 00:00:00

  • Bisphosphonate-related osteonecrosis of the jaw in non-malignant bone disease.

    abstract::Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with dela...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Wong PK,Borromeo GL,Wark JD

    更新日期:2013-09-01 00:00:00

  • Exercise capacity in relation to autoantibodies in systemic sclerosis patients.

    abstract::Autoantibodies have been detected in systemic sclerosis patients, and typical clinical features regarding organ involvement by each autoantibody have been reported. To reveal differences in exercise intolerance in patients with either anti-topoisomerase-I or anti-centromere antibodies, 53 systemic sclerosis patients w...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Someya F,Mugii N,Yahata T,Nakagawa T

    更新日期:2013-11-01 00:00:00

  • Prevalence of other connective tissue diseases in idiopathic inflammatory myopathies.

    abstract::We sought to determine the prevalence of additional connective tissue diseases (CTDs) in patients with idiopathic inflammatory myopathies (IIM), and to study the muscle biopsy patterns in various clinico-serologic subsets of myositis. We undertook a retrospective cohort study of 648 patients with a histological diagno...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Maundrell A,Proudman S,Limaye V

    更新日期:2019-10-01 00:00:00

  • Relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome.

    abstract::A case of relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome is described. The pattern of vascular involvement supports the inclusion of relapsing polychondritis within the spectrum of systemic vasculitides. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Giordano M,Valentini G,Sodano A

    更新日期:1984-01-01 00:00:00

  • Failure of the serological determination of HLA-B27 due to antigen masking in patients with ankylosing spondylitis.

    abstract::In patients suffering from ankylosing spondylitis (AS) HLA-B27 determination by means of the microlymphocytotoxicity test (MLCT) sometimes gives equivocal or false-negative results even though it has been performed with meticulous care. These failures of the test did not arise when the isolated mononuclear cells (MNC)...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Neumüller J,Fischer M,Eberl R

    更新日期:1993-01-01 00:00:00

  • Serum oxidized low-density lipoproteins in rheumatoid arthritis.

    abstract:OBJECTIVE:The aim of this study was to measure serum oxidized low-density lipoprotein (Ox-LDL) levels in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and to identify any association with clinical variables. METHODS:We studied 126 female patients (27 with active RA, 27 with inactive RA,...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kim SH,Lee CK,Lee EY,Park SY,Cho YS,Yoo B,Moon HB

    更新日期:2004-07-01 00:00:00

  • The right place of interleukin-1 inhibitors in the treatment of Behçet's syndrome: a systematic review.

    abstract::Behçet's syndrome (BS) is a chronic (auto)-inflammatory disorder characterized by different clusters of symptoms, including mucocutaneous and ocular involvements. Interleukin-1 inhibitors anakinra (ANA), canakinumab (CAN), and gevokizumab (GEV) represent a promising therapeutic alternative in BS. To date, evidence on ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bettiol A,Silvestri E,Di Scala G,Amedei A,Becatti M,Fiorillo C,Lopalco G,Salvarani C,Cantarini L,Soriano A,Emmi G

    更新日期:2019-06-01 00:00:00

  • Comparison of an administrative algorithm for SLE disease severity to clinical SLE Disease Activity Index scores.

    abstract::Systemic lupus erythematosus (SLE) severity, reflecting both disease intensity and duration, is heterogeneous making it challenging to study in administrative databases where severity may confound or mediate associations with outcomes. Garris et al. developed an administrative claims-based algorithm employing claims o...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Speyer CB,Li D,Guan H,Yoshida K,Stevens E,Jorge AM,Everett BM,Feldman CH,Costenbader KH

    更新日期:2020-02-01 00:00:00

  • ESSDAI activity index of the SJÖGRENSER cohort: analysis and comparison with other European cohorts.

    abstract::The objective of the study was to assess the ESSDAI index characteristics in the SJÖGRENSER cohort (Spanish Rheumatology Association's registry of patients with Primary Sjögren Syndrome [PSS]). SJÖGRENSER is a prospective multicentric study on a cohort of Spanish patients with PSS who meet the 2002 American-European c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Rosas J,Sánchez-Piedra C,Fernández-Castro M,Andreu JL,Martínez-Taboada V,Olivé A,SJÖGRENSER Group, part of the Spanish Society of Rheumatology Systemic Autoimmune Diseases Study Group (EASSER).

    更新日期:2019-06-01 00:00:00

  • Do Heberden and Bouchard nodes affect finger dexterity in elderly?

    abstract::Elderly often have Heberden nodes (HN) and Bouchard nodes (BN) that may affect finger dexterity. The aim of this cross-sectional study was to assess an effect of HN and BN on finger dexterity of the elderly. The nine-hole peg test was used for dexterity measurement in 200 elderly with HN and/or BN. Mean age was 68.6 +...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kitisomprayoonkul W,Promsopa K,Chaiwanichsiri D

    更新日期:2010-02-01 00:00:00

  • Patterns of circulatory and peripheral blood mononuclear cytokines in rheumatoid arthritis.

    abstract::An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Azizieh FY,Al Jarallah K,Shehab D,Gupta R,Dingle K,Raghupathy R

    更新日期:2017-10-01 00:00:00

  • Fibrodysplasia ossificans progressiva without characteristic skeletal anomalies.

    abstract::Fibrodysplasia ossificans progressiva (FOP) is a rare but extremely disabling genetic disease of the skeletal system. This disease is characterized by progression of heterotopic ossification within skeletal muscles, ligaments and tendons. Most patients with FOP are misdiagnosed early in life before the appearance of h...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ulusoy H

    更新日期:2012-05-01 00:00:00

  • Cryoglobulins in cases of rheumatoid arthritis.

    abstract::Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distribu...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Chattopadhya D,Ravindran B,Prakash K

    更新日期:1985-01-01 00:00:00

  • Serum serotonin levels and bone in rheumatoid arthritis patients.

    abstract::In rheumatoid arthritis (RA), a disease characterized by bone loss, increased levels of serotonin have been reported. Recent studies have demonstrated a role for circulating serotonin as a regulator of osteoblastogenesis, inhibiting bone formation. Thus, we measured serum serotonin levels (SSL) in a Portuguese sample ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bernardes M,Vieira T,Lucas R,Pereira J,Costa L,Simões-Ventura F,Martins MJ

    更新日期:2017-11-01 00:00:00

  • High frequencies of HLA-B27 in Chinese patients with suspected of ankylosing spondylitis.

    abstract::This study was performed to investigate the frequency of human leukocyte antigen (HLA)-B27 in Chinese patients with suspected of ankylosing spondylitis (AS) and to assess the clinical significance of HLA-B27 typing. A total of 1,016 patients suspected of AS were classified into six groups based on one major AS-related...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Liu X,Li YR,Hu LH,Zhou ZM,Chen FH,Ning Y,Yao QF

    更新日期:2010-08-01 00:00:00

  • Comorbidities in psoriatic arthritis: a systematic review and meta-analysis.

    abstract::The aims of this systematic review and meta-analysis were to: (1) describe the prevalence of commonly reported comorbidities in psoriatic arthritis (PsA), (2) compare the incidence and/or prevalence of comorbidities between PsA and control populations; and (3) examine the impact of comorbidities on PsA outcomes. We sy...

    journal_title:Rheumatology international



    authors: Gupta S,Syrimi Z,Hughes DM,Zhao SS

    更新日期:2021-02-01 00:00:00

  • Anterior uveitis in patients with spondyloarthropathies in a single US academic center: a retrospective study.

    abstract::Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Gevorgyan O,Riad M,Sarran RD,Merrill PT,Block JA,Castrejon I

    更新日期:2019-09-01 00:00:00

  • Thrombocytopenia as a presenting feature of Kawasaki disease: a case series from North India.

    abstract::Thrombocytosis is well described in children with Kawasaki disease (KD). We describe six children with KD who had thrombocytopenia at disease onset. This is an unusual finding and has clinical implications in the diagnosis of this condition. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Singh S,Gupta D,Suri D,Kumar RM,Ahluwalia J,Das R,Varma N

    更新日期:2009-12-01 00:00:00

  • Sense of coherence and self-sacrificing defense style as predictors of psychological distress and quality of life in rheumatoid arthritis: a 5-year prospective study.

    abstract::Individual differences in adjustment during a disease's course determine psychological response and outcome. This study aimed to investigate prospectively whether coping with health stressors and self-sacrificing defense style could predict psychological adjustment and health-related quality of life (HRQoL) in patient...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Goulia P,Voulgari PV,Tsifetaki N,Andreoulakis E,Drosos AA,Carvalho AF,Hyphantis T

    更新日期:2015-04-01 00:00:00

  • Perception, knowledge, and use by general practitioners of Belgium of a new WHO tool (FRAX) to assess the 10-year probability of fracture.

    abstract::The FRAX tool that calculates the 10-year probability of having a fracture has recently been validated for Belgium. Little is known about the perception and knowledge that GPs have about this tool in their daily practice. A survey has been conducted as part of a screening campaign for various diseases. The primary obj...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bruyère O,Nicolet D,Compère S,Rabenda V,Jeholet P,Zegels B,Maassen P,Pire G,Reginster JY

    更新日期:2013-04-01 00:00:00

  • Adherence to best practice consensus guidelines for familial Mediterranean fever: a modified Delphi study among paediatric rheumatologists in Turkey.

    abstract:BACKGROUND:Although not validated fully, recommendations are present for diagnosis, screening and treatment modalities of patients with familial Mediterranean fever (FMF). OBJECTIVE:To review the current practices of clinicians regarding FMF and reveal their adherence to consensus guidelines. METHODS:Fifteen key poin...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kavrul Kayaalp G,Sozeri B,Sönmez HE,Demir F,Cakan M,Oztürk K,Karadag SG,Otar Yener G,Ozdel S,Baglan E,Celikel E,Sahin N,Gezgin Yildirim D,Eker Omeroglu R,Aktay Ayaz N,PeRA-Research Group.

    更新日期:2021-01-16 00:00:00

  • Pattern of bone mineral density in idiopathic male osteoporosis.

    abstract::The mechanisms of male idiopathic osteoporosis are little known. We evaluated bone mineral loss by dual-energy X-ray absorptiometry and determined its cortical or trabecular nature in a cohort of men with idiopathic osteoporosis with fractures. Thirty-nine men (mean age 60 ± 13 years), with negative investigations for...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Laroche M

    更新日期:2012-10-01 00:00:00