Abstract：
:CD4(+) T cells from patients with systemic lupus erythematosus (SLE) exhibit increased expression of various proteins contributing to defective function of CD4(+) T cells. We evaluated the transcript and protein levels of perforin (PRF1) in CD4(+) T cells from SLE patients (n = 41) and healthy individuals (n = 34). The CD4(+) T cells were obtained by a positive biomagnetic separation system. The amounts of mRNA were determined by reverse transcription and real-time quantitative PCR. The protein levels in the CD4(+) T cells were evaluated by Western blotting analysis. We observed significantly higher levels of PRF1 protein (p = 0.013) in SLE CD4(+) T cells than in controls. There was no significant increase in PRF1 transcript levels (p = 0.908) in CD4(+) T cells from SLE patients as compared to healthy individuals. Moreover, we did not observe a correlation between PRF1 transcript and protein levels in SLE CD4(+) T cells and disease activity expressed by the SLEDAI scale. We confirmed previous observations that demonstrated higher levels of PRF1 protein in CD4(+) T cells from SLE patients. However, we did not find a correlation between PRF1 transcripts and proteins in CD4(+) T cells and SLE disease activity.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kozłowska A,Hrycaj P,Łącki JK,Jagodziński PPdoi
10.1007/s00296-009-1329-1subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1627-33issue
12eissn
0172-8172issn
1437-160Xjournal_volume
30pub_type
杂志文章abstract：:Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0638-0
更新日期：2008-11-01 00:00:00
abstract：:We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3618-9
更新日期：2017-01-01 00:00:00
abstract：:To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2463-8
更新日期：2013-04-01 00:00:00
abstract：:Gout results from multifactor interactions between gender, age, genetic and environmental factors. Environmental factors underlying gout and precipitating factors triggering acute attacks might vary in different populations with different lifestyles. In this study, we aimed to collect data regarding the demographic an...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-012-2442-0
更新日期：2013-04-01 00:00:00
abstract：:Postural changes are sometimes a risk factor for low back pain. Abnormal posture creates a strain on ligaments and muscles that indirectly affects the curvature of the lumbar spine. This study was planned to investigate the relationship between the angles of the lower lumbar spine and spinal mobility in acute and chro...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0268-x
更新日期：2003-07-01 00:00:00
abstract：:Joint destruction and excessive bone formation are associated with high expression of soluble receptor activator of nuclear factor-κB ligand (sRANKL). This study was undertaken to investigate the role of sRANKL in collagenase-induced osteoarthritis (CIOA) in mice and in patients with osteoarthritis (OA). The initial p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1723-8
更新日期：2012-05-01 00:00:00
abstract：:The association of familial Mediterranean fever (FMF) and polyarteritis nodosa (PAN) has been well established. These patients have been reported to have an overall better prognosis than other PAN patients. Herein we report a patient with FMF and PAN who died of sepsis following a severe course of recurrent bleeding e...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0424-y
更新日期：2005-01-01 00:00:00
abstract：:The American Rheumatism Association (ARA) clinical criteria have been tested in systemic lupus erythematosus (SLE), progressive systemic sclerosis, polyarteritis nodosa and polymyositis/dermatomyositis. Hospital admissions from a defined population over the same period were studied. Increased weighting of the scores f...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541261
更新日期：1981-01-01 00:00:00
abstract：:Neuropathic arthropathy (NA), known as Charcot neuroarthropathy, is a chronic, degenerative arthropathy and is associated with decreased sensory innervation. Numerous causes of this arthropathy have been described. Neuropathic joint, although first described by Charcot in tabes dorsalis in 1868, has subsequently been ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1013-5
更新日期：2010-05-01 00:00:00
abstract：:We aimed to evaluate the cost-effectiveness of certolizumab pegol (CZP), a pegylated fc-free anti-TNF, as add-on therapy to methotrexate (MTX) versus etanercept, adalimumab, or golimumab in patients with moderate-to-severe active rheumatoid arthritis (RA) not responding to the conventional synthetic disease-modifying ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3736-z
更新日期：2017-09-01 00:00:00
abstract：:We evaluated the frequency of secondary amyloidosis, associated clinical features, and outcomes in ankylosing spondylitis (AS) patients diagnosed in the last decade. The medical records of AS patients diagnosed at single academic medical center were reviewed for clinical evidence of amyloidosis. During routine follow-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2646-3
更新日期：2013-07-01 00:00:00
abstract：:To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2676-5
更新日期：2013-08-01 00:00:00
abstract：:Reduction in jaw opening is a neglected symptom of giant cell arteritis (GCA) in clinical practice and in the scientific literature. We describe the case of a 71-year-old woman with GCA who was misdiagnosed as occipital neuritis and craniomandibular dysfunction because of headaches in the occipital region and reductio...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1690-0
更新日期：2011-11-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) is a rare systemic vasculitis affecting multiple organs. Current standard treatment includes the use of glucocorticoids and cyclophosphamide. Unfortunately, some patients do not respond to this treatment and other therapeutic options are needed. We present a case of a young male with refract...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4210-2
更新日期：2019-02-01 00:00:00
abstract：:The fibromyalgia syndrome (FMS) is a chronic, widespread pain disorder of unknown etiology. It has been suggest that familial component, environmental factors, endocrine and neurotransmitter alterations, and psychological factors may contribute to the development of FMS. The role of melatonin in FMS is unclear. Some s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2315-y
更新日期：2013-06-01 00:00:00
abstract：:Treatment of acute gout consists of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and steroids. However, the typical patient with gout has multiple comorbidities such as cardiovascular disease, hypertension, renal dysfunction or diabetes/metabolic syndrome that represent contraindications to these therape...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04659-5
更新日期：2020-12-01 00:00:00
abstract：:Previous studies have demonstrated an increased risk of breast cancer among patients with systemic sclerosis (scleroderma). To describe the clinical characteristics of 21 patients with both systemic sclerosis and breast cancer, and compare their risk factors to female scleroderma patients without breast cancer, in a p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0540-9
更新日期：2008-07-01 00:00:00
abstract：:Increased QT interval dispersion has been associated with an increased risk for ventricular arrhythmias and sudden cardiac events. We examined the QT interval dispersion in 20 North Indian children with Kawasaki disease (KD) with no coronary artery abnormalities on echocardiography compared the same with matched contr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1252-5
更新日期：2011-03-01 00:00:00
abstract：:To investigate the clinical manifestations and outcomes of musculoskeletal (MSK) nontuberculous mycobacterium (NTM) infections. This study was a retrospective cohort study using the Siriraj Hospital database from 2005 to 2017. Enrolled were all patients aged 15 or older who had an MSK infection with NTM identified in ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04392-8
更新日期：2019-10-01 00:00:00
abstract：:Patients with rheumatoid arthritis (RA) have a high risk for comorbid conditions which increase mortality, hospital admissions, costs of care and inability. To evaluate the prevalence of comorbidities in Mexican mestizo patients with RA and determine the associated risk factors. Cross-sectional study in which RA patie...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3769-3
更新日期：2017-09-01 00:00:00
abstract：:The group of autoimmune cutaneous connective tissue diseases (CCTD) includes systemic sclerosis, dermatomyositis (DM), lupus erythematosus (LE), and subtypes. Most CCTD patients can be assigned to one of these phenotypes or mixed forms, and transitions among the subsets exist. We present the case of a 26-year-old woma...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0354-8
更新日期：2004-03-01 00:00:00
abstract：:Knee osteoarthritis is a common disease in the elderly population worldwide. The alleviation of the symptoms associated with this disease can be achieved with physical exercise that induces a cascade of molecular and cellular processes. Of the neurotrophins, brain-derived neurotrophic factor (BDNF) appears to be the m...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2786-0
更新日期：2014-06-01 00:00:00
abstract：:Pancreatitis is a relatively rare but severe manifestation in systemic lupus erythematosus (SLE) patients. We report a case of a 39-year-old woman with previous SLE diagnose treated with prednisone and mycophenolate mofetil who developed an acute pancreatitis complicated by pancreatic pseudocysts within the context of...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0964-x
更新日期：2010-03-01 00:00:00
abstract：:We report a case of visceral leishmaniasis in a patient from northern Norway with psoriatic arthritis treated with a combination of etanercept and methotrexate. The patient resided extensively in southern Spain, a zone endemic for leishmania. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2483-4
更新日期：2013-10-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scar...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00296-017-3784-4
更新日期：2017-10-01 00:00:00
abstract：:Macrophagic myofascitis (MMF) is an unusual inflammatory myopathy characterized by muscle infiltration by macrophages and lymphocytes. Here, we describe a case of MMF which is associated with rheumatoid arthritis. A 53-year-old Japanese rheumatoid arthritis (RA) patient presented with focal tenderness of lower extremi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1015-3
更新日期：2010-05-01 00:00:00
abstract：:Systemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathogenesis of fibrosis, inflammation and vascular abnormalities. This study was aimed to investigate the relation between SSc and Rho/Rho-kinase gene po...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-015-3400-4
更新日期：2016-03-01 00:00:00
abstract：:Several molecular epidemiological studies have been conducted in recent years to evaluate a possible association between the interferon regulatory factor 5 (IRF5) rs2004640 polymorphism and rheumatoid arthritis risk in diverse populations. However, the results remain conflicting rather than conclusive. Our aim was to ...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-013-2806-0
更新日期：2013-11-01 00:00:00
abstract：:Statistical analysis plays a critical role in data interpretation in all fields and particularly so for clinical data where important treatment decisions are made. We provide here an in-depth and illustrative analysis to examine patterns and radiographic scores in an early disease rheumatoid arthritis cohort over a 3-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2879-9
更新日期：2014-02-01 00:00:00
abstract：:To assess the prognostic value of scleroderma pattern of nailfold capillary changes for the development of connective tissue diseases (CTD) in subjects with primary Raynaud's phenomenon (RP). The study included 3,029 consecutive patients with primary RP who had been followed at 6-month intervals during the mean of 4.8...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2109-2
更新日期：2012-10-01 00:00:00
