Abstract：
:To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hypothermia induced by 5'-AMP could be effectively inhibit the inflammation on acute gouty arthritis in rats. AMP-induced hypothermia has protective effects on our acute gouty arthritis, which was demonstrated by the following criteria: (1) a significant reduction in the ankle swelling (p < 0.001); (2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; (3) a significant reduction in the presence of serum Interleukin-1β (IL-1β, p < 0.001) and metalloproteinase-9 (MMP-9, p < 0.001); and (4) a significant inhibition in the Nuclear Factor -κappaB (NF-κB) activity (p < 0.001). AMP-induced hypothermia could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Miao Z,Guo W,Lu S,Lv W,Li C,Wang Y,Zhao S,Yan S,Tao Z,Wang Ydoi
10.1007/s00296-013-2676-5subject
Has Abstractpub_date
2013-08-01 00:00:00pages
2085-92issue
8eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract：:IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274884
更新日期：1991-01-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) related to hepatitis B is an uncommon vasculitis that is sometimes associated with the rapid progression of distal ischemia. A few recent reports have proposed the use of antiviral therapy. However, there is not yet a consensus for the standard treatment of this disease entity and none of th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0103-x
更新日期：2006-08-01 00:00:00
abstract：:To develop a semi-automated method to quantify inflammation in sacroiliac (SI) joints by measuring bone marrow edema (BME) on MRI. The SCAISS was designed as an image-processing software. Validation followed: (1) three readers evaluated SI images of 23 patients with axial SpA and various levels of BME severity with th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4104-3
更新日期：2018-10-01 00:00:00
abstract：:Behçet's disease (BD) is a variable vessel vasculitis characterized by recurrent oral and genital aphthosis accompanied by skin, ocular, gastrointestinal, neurologic, and articular involvement. BD is not common in childhood and the disease characteristics considerably differ between adults and children. 18 diagnostic/...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4208-9
更新日期：2019-01-01 00:00:00
abstract：:The aim of this study was to analyze the longitudinal practice patterns of prophylaxis of glucocorticoid-induced osteoporosis in patients with polymyalgia rheumatica (PMR). Patients diagnosed with PMR were collected retrospectively in two rheumatology departments. In addition to demographic and diagnostic criteria, th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3014-2
更新日期：2014-10-01 00:00:00
abstract：:The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the ne...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1672-2
更新日期：2011-08-01 00:00:00
abstract：:The objectives of this study are to describe appropriateness and drug treatment of comorbidities in fibromyalgia (FM). Cross-sectional study of a group of patients. Number of drugs, indication, duration and appropriateness of prescriptions were evaluated. Patients were classified as: group 1, (FM/FM) previous FM diagn...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3568-2
更新日期：2016-12-01 00:00:00
abstract：:Various surgical procedures including percutaneous and open release and arthroscopic procedures have been described to treat recalcitrant tennis elbow. We present the outcome of Boyd-McLeod surgical procedure for tennis elbow resistant to non-operative treatment in twenty-seven patients (twenty-nine limbs). Boyd McLeo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1450-1
更新日期：2011-08-01 00:00:00
abstract：:Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2895-9
更新日期：2014-02-01 00:00:00
abstract：:Objective of the study is to investigate how compliance during the first year of methotrexate (MTX) treatment in rheumatoid arthritis (RA) is influenced by the patients' perception of the necessity for and concern about MTX, the patients' functional disability, and the dose of MTX. A total of 126 RA patients completed...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1160-8
更新日期：2010-09-01 00:00:00
abstract：:The aim of the present study was to evaluate the effects of an exercise training program on lipid profile and composition of high-density lipoprotein (HDL) subfractions in systemic lupus erythematosus (SLE) patients and healthy controls. A 12-week, randomized trial was conducted. Thirty-three physically inactive SLE p...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-014-3081-4
更新日期：2015-01-01 00:00:00
abstract：:The aim of the study is to study the relationship between androgen levels and bone mineral density (BMD) in elderly Arab males. Forty-five elderly Arab males underwent Dual X-ray absorptiometry for measurement of BMD. The outcomes were defined as per WHO description. Assays for testosterone (T), gonadotropins (LH and ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0970-z
更新日期：2010-01-01 00:00:00
abstract：:Sleep disturbances and problems are increased in ankylosing spondylitis (AS). But much is not known in a quantitative way about sleep problems and effect of treatments on AS. This study is aimed first, to investigate sleep disturbances in AS and secondly, to evaluate the effects of anti-TNF treatment on SD in AS. One ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1907-x
更新日期：2012-07-01 00:00:00
abstract：:Solid organ transplantation is an important lifesaving procedure mainly performed in patients with end-stage organ failure such as liver cirrhosis, congestive heart failure, and end-stage renal disease. While these complications are among the most preventable adverse effects of solid organ transplantation, these are g...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1970-3
更新日期：2012-08-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease characterized by the production of autoantibodies against a spectrum of nuclear antigens. RANTES and its receptor CCR5 have been associated with the pathogenesis of SLE. The objective of this study is to analyze autoantibodies (DNA/RNA), al...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2812-2
更新日期：2013-11-01 00:00:00
abstract：:The results from previous studies on association of IL-6 -174 G/C and -572 G/C polymorphisms with the risk of systemic lupus erythematosus (SLE) remained inconsistent. Therefore, a meta-analysis was performed to assess the association between these two polymorphisms and SLE susceptibility. A literature-based search wa...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00296-013-2855-4
更新日期：2014-02-01 00:00:00
abstract：:In the present study, we have investigated comparatively the inflammatory response of patients with active and inactive osteoarthritis. The sera from 31 healthy individuals, 37 patients with active OA, and 19 patients with inactive OA were assayed for TNF-alpha, IL-6, sRANKL, RANTES, and MRP8 using ELISA in order to e...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0864-0
更新日期：2009-08-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) patients have high risk for anxiety and depression. We aimed to investigate the prevalence and risk factors of anxiety and depression in SLE patients in Southwest China. Participants were recruited by convenience sampling from Rheumatic Outpatient Clinic of West China Hospital Sichua...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3559-3
更新日期：2016-12-01 00:00:00
abstract：:Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2493-2
更新日期：2013-10-01 00:00:00
abstract：:Ultrasonography (US) and power Doppler sonography (PDS) was used to investigate causes of new onset of shoulder pain and sites of shoulder inflammation in 157 shoulders of 99 patients with rheumatoid arthritis (RA). US detected effusion and/or synovitis in 92/157 glenohumeral joints, subdeltoid bursitis in 56/157 shou...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0465-8
更新日期：2008-03-01 00:00:00
abstract：:Behçet's disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus formation (ICTF) is an uncommon but important complication of BD. To highlight recent insights into this disease, we aimed to review ICTF and other systemic involvements associated with ICTF in BD. We conducted a comprehensive review o...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-014-3174-0
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0556-8
更新日期：2006-01-01 00:00:00
abstract：:As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibr...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-007-0403-9
更新日期：2007-09-01 00:00:00
abstract：:Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541352
更新日期：1985-01-01 00:00:00
abstract：:Noninvasive assessment of endothelial dysfunction (ED) and diagnosing the early vascular development of atherosclerosis in active mucocutaneous Behçet's disease. Twenty-nine active BD patients (study group) without any obstructive vascular involvement were compared with twenty-nine healthy controls (control group) in ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0491-6
更新日期：2008-05-01 00:00:00
abstract：:There are numerous causes of pulmonary cavitary lesions as infection (bacterial, parasitic and invasive fungal), Wegener granulomatosis (WG) and other vasculitis, sarcoidosis, malignancy, septic thromboembolism, airways disease (cystic bronchiectasis and bullae), pneumatoceles and traumatic parenchymal laceration. Her...
journal_title：Rheumatology international
pub_type： 信件
doi：10.1007/s00296-012-2424-2
更新日期：2013-08-01 00:00:00
abstract：:Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4102-5
更新日期：2018-09-01 00:00:00
abstract：:Several studies of rheumatoid arthritis (RA) incidence and prevalence indicate that occurrence of the disease varies significantly among different populations. We aimed to estimate the prevalence and incidence of RA in South Korea. We used Korean National Health Insurance (NHI) claims data to estimate the prevalence o...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2590-2
更新日期：2013-06-01 00:00:00
abstract：:Aseptic loosening is the predominant cause of total hip implant failure. It has been assumed that a layer or membrane, containing macrophages, fibroblasts and vascular endothelial cells, of synovial-like tissue develops at the implant-to-bone interface almost invariably and, with time, somehow leads to loosening of th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050037
更新日期：1998-01-01 00:00:00
abstract：:The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1alpha and tumor necrosis factor (TNF) alpha, and the concentration...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0350-5
更新日期：2007-09-01 00:00:00
