Abstract:
:Joint destruction and excessive bone formation are associated with high expression of soluble receptor activator of nuclear factor-κB ligand (sRANKL). This study was undertaken to investigate the role of sRANKL in collagenase-induced osteoarthritis (CIOA) in mice and in patients with osteoarthritis (OA). The initial phase of CIOA was associated with severe proteoglycan depletion, decreased collagen density, and up-regulation of bone morphogenetic protein (BMP)-2. At the late stage of CIOA, bone remodeling was related with increased BMP2 and RANKL expression in the joints, high sRANKL, and decreased number of activated neutrophils in synovium. CIOA mice showed elevated plasma level of sRANKL but low RANKL expression on blood neutrophils. The percentage of RANKL-positive blood neutrophils was higher in patients with OA than in healthy individuals. Our data indicate that increased local and systemic levels of soluble RANKL might be indicative for OA disorders in mouse and human.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Dimitrova P,Toncheva A,Gyurkovska V,Ivanovska Ndoi
10.1007/s00296-010-1723-8subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1317-25issue
5eissn
0172-8172issn
1437-160Xjournal_volume
32pub_type
杂志文章abstract::Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease but it has been found in many other autoimmune diseases like systemic lupus erythematosus (SLE). Furthermore, cross-reactive epitopes on β2-glycoprotein I (β2GPI) and Saccharomyces cerevisiae were found in SLE patients. T...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2431-3
更新日期:2013-03-01 00:00:00
abstract::Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-009-1145-7
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Recent studies revealed trisomy 7 as a chromosomal abnormality in non-neoplastic disorders such as rheumatoid arthritis (RA). In the present study, we investigated the presence of trisomy 7 in the synovial fluid cells of patients with RA using fluorescence in situ hybridisation (FISH) analysis. METHODS:Synov...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0477-6
更新日期:2005-10-01 00:00:00
abstract::Catalase (CAT) and peroxisome proliferator activated receptor-gamma2 (PPARgamma2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARgamma2 genotypes and risk and severity of RA using 474...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0013-3
更新日期:2006-03-01 00:00:00
abstract::Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 pat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2821-1
更新日期:2013-11-01 00:00:00
abstract::It is proposed that synovial fluid biomarkers may help in differentiating the type of arthritis. The aim of study is to determine whether synovial fluid adenosine deaminase (ADA) and high-sensitivity C-reactive protein (hs-CRP) can be useful in this regard. A total of 75 patients with knee monoarthritis that were admi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1602-3
更新日期:2012-01-01 00:00:00
abstract::The objective of this study is to describe the interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients of China, and to study clinical significance of high-resolution computed tomography (HRCT) in evaluation and treatment. One hundred and ten Chinese patients (79 women and 31 man) diagnosed with RA betwe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1665-1
更新日期:2012-03-01 00:00:00
abstract::The purpose of this study was to determine the effects of an oral preparation containing hyaluronic acid on osteoarthritic knee joint pain and function as well as changes in inflammatory cytokines, bradykinin, and leptin. We also used heavy water to determine the turnover rates of glycosaminoglycans in synovial fluid....
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-014-3047-6
更新日期:2015-01-01 00:00:00
abstract::We report our experience and hypothesis on the diagnosis and treatment of patients with vasculitis who are simultaneously diagnosed with serum-positive cytomegalovirus (CMV) immunoglobulin (Ig)M antibodies and negative CMV DNA polymerase chain reaction (PCR). It remains unknown how to treat this kind of "phantom" CMV ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0522-5
更新日期:2005-10-01 00:00:00
abstract::In patients suffering from ankylosing spondylitis (AS) HLA-B27 determination by means of the microlymphocytotoxicity test (MLCT) sometimes gives equivocal or false-negative results even though it has been performed with meticulous care. These failures of the test did not arise when the isolated mononuclear cells (MNC)...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301265
更新日期:1993-01-01 00:00:00
abstract::Diabetic muscular infarct (DMI) is a rare condition, which begins with acute onset of extremity pain and swelling. Patients usually have long-standing disease and poorly controlled diabetes mellitus (DM). Thigh muscle group is the most commonly involved side, while lower leg involvement is rare. We represent herein a ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1759-9
更新日期:2012-02-01 00:00:00
abstract::C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00302150
更新日期:1992-01-01 00:00:00
abstract::To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2676-5
更新日期:2013-08-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scar...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00296-017-3784-4
更新日期:2017-10-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of an exercise training program on lipid profile and composition of high-density lipoprotein (HDL) subfractions in systemic lupus erythematosus (SLE) patients and healthy controls. A 12-week, randomized trial was conducted. Thirty-three physically inactive SLE p...
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-014-3081-4
更新日期:2015-01-01 00:00:00
abstract::To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2463-8
更新日期:2013-04-01 00:00:00
abstract::Monocyte interleukin-1 (IL-1) production in vitro was studied in 49 patients with rheumatoid arthritis (RA) and 31 controls. Twenty-six of the RA patients were studied prospectively for up to 12 months after beginning chrysotherapy. About half of the patients (group 1) exhibited pretreatment levels of monocyte IL-1 se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274840
更新日期:1990-01-01 00:00:00
abstract::To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-4150-x
更新日期:2018-12-01 00:00:00
abstract::Several molecular epidemiological studies have been conducted in recent years to evaluate a possible association between the interferon regulatory factor 5 (IRF5) rs2004640 polymorphism and rheumatoid arthritis risk in diverse populations. However, the results remain conflicting rather than conclusive. Our aim was to ...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s00296-013-2806-0
更新日期:2013-11-01 00:00:00
abstract::Activated T lymphocytes (Ia+ T-cells) in peripheral blood are associated with immune stimulation. We found the percentages of these cells significantly increased in 95% of rheumatoid arthritis (RA) patients. Our studies showed no relation between the percentages of these cells in peripheral blood and concurrent erythr...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00272435
更新日期:1988-01-01 00:00:00
abstract::The results of some epidemiological studies point to the presence of an increased risk of cardiovascular disease (CVD), particularly atherosclerosis and congestive heart failure (CHF) in rheumatoid arthritis (RA). At least 50% of abnormalities remained asymptomatic. Pathological conditions contributing to myocardial d...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0473-8
更新日期:2008-04-01 00:00:00
abstract::Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0162-z
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:To identify recommendations on the diagnosis and management of rheumatoid arthritis (RA) supported by low recommendation grades, to study the causes of this low grading, and to propose solutions. METHODS:A group of six rheumatologists, with extensive experience in the development of systematic reviews, revi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04724-z
更新日期:2021-01-01 00:00:00
abstract::We have examined the way in which products of cultured human blood mononuclear cells activate human articular chondrocytes. Conditioned medium from mononuclear cells enhanced the production of prostaglandin E by cultured human chondrocytes and also stimulated fibrinolytic activity in these cultures. These two effects ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541204
更新日期:1984-01-01 00:00:00
abstract::The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1176-0
更新日期:2010-09-01 00:00:00
abstract::We report a 34-year-old female case of diffuse systemic sclerosis (SSc) with generalized ectopic calcification, who developed severe headache with vertical atlantoaxial subluxation (AAS) complicated by calcification around the odontoid process (crowned dens pattern calcification). Although a rare complication, AAS sho...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1703-z
更新日期:2011-09-01 00:00:00
abstract::Establishing prevention and therapeutic strategies for osteoarthritis (OA) is necessary to minimize functional disability and the impact of the disease on society. The aim of this study was to determine the effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3148-2
更新日期:2015-03-01 00:00:00
abstract::The objective of the study was to determine the clinical features and treatment course in Canadian patients with dermatomyositis (DM) associated with the anti-melanoma differentiation-associated gene 5 antibody (MDA5). A retrospective chart review of consecutive patients with anti-MDA5 antibody DM from two Canadian te...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04398-2
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:Examine the association between physical activity and sedentary time with high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. We also investigated the dose of physical activity that was associated with lower clinical levels of high sensitivity C-Reactive protein (< 3 mg/L). MA...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04571-y
更新日期:2020-09-01 00:00:00
abstract::Our study was aimed to clarify an association between gastrointestinal (GI) amyloid-positive area and various kinds of factors including renal function in reactive amyloidosis associated with rheumatoid arthritis (RA). Twenty-five patients with an established diagnosis of reactive AA amyloidosis participated in the st...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1719-4
更新日期:2012-04-01 00:00:00