Abstract:
:Joint destruction and excessive bone formation are associated with high expression of soluble receptor activator of nuclear factor-κB ligand (sRANKL). This study was undertaken to investigate the role of sRANKL in collagenase-induced osteoarthritis (CIOA) in mice and in patients with osteoarthritis (OA). The initial phase of CIOA was associated with severe proteoglycan depletion, decreased collagen density, and up-regulation of bone morphogenetic protein (BMP)-2. At the late stage of CIOA, bone remodeling was related with increased BMP2 and RANKL expression in the joints, high sRANKL, and decreased number of activated neutrophils in synovium. CIOA mice showed elevated plasma level of sRANKL but low RANKL expression on blood neutrophils. The percentage of RANKL-positive blood neutrophils was higher in patients with OA than in healthy individuals. Our data indicate that increased local and systemic levels of soluble RANKL might be indicative for OA disorders in mouse and human.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Dimitrova P,Toncheva A,Gyurkovska V,Ivanovska Ndoi
10.1007/s00296-010-1723-8subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1317-25issue
5eissn
0172-8172issn
1437-160Xjournal_volume
32pub_type
杂志文章abstract::Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1 mA, 10 Hz EA ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1364-y
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2009-5
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abstract:PURPOSE:Examine the association between physical activity and sedentary time with high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. We also investigated the dose of physical activity that was associated with lower clinical levels of high sensitivity C-Reactive protein (< 3 mg/L). MA...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04571-y
更新日期:2020-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274821
更新日期:1990-01-01 00:00:00
abstract::Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Tur...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960100132
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270466
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3618-9
更新日期:2017-01-01 00:00:00
abstract::The clinical use of pulsed electromagnetic fields (PEMF) in osteoarticular pathology is widely extended, although the mechanisms involved are unknown. The aim of this study was to evaluate the action of a new protocol of treatment with PEMF on liquid medium cultures of fibroblast-like cells derivates of mononuclear pe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1488-0
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541334
更新日期:1985-01-01 00:00:00
abstract::Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04689-z
更新日期:2021-02-01 00:00:00
abstract::Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541597
更新日期:1983-01-01 00:00:00
abstract::Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with dela...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-013-2771-7
更新日期:2013-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0107-6
更新日期:2006-09-01 00:00:00
abstract::To develop a semi-automated method to quantify inflammation in sacroiliac (SI) joints by measuring bone marrow edema (BME) on MRI. The SCAISS was designed as an image-processing software. Validation followed: (1) three readers evaluated SI images of 23 patients with axial SpA and various levels of BME severity with th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4104-3
更新日期:2018-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1273-0
更新日期:2011-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3839-6
更新日期:2018-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3201-1
更新日期:2015-06-01 00:00:00
abstract::Chondrocyte structure and function under the influence of two gold-containing therapeutic agents, aurothioglucose and triethylphosphine gold, were studied in a monolayer culture system for cultivating lapine articular chondrocytes. The functional parameters investigated were chondrocyte proliferation and the incorpora...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541144
更新日期:1983-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2937-3
更新日期:2014-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3994-4
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pub_type: 杂志文章
doi:10.1007/s00296-002-0210-2
更新日期:2002-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541361
更新日期:1984-01-01 00:00:00
abstract::Chronic inflammatory syndromes such as rheumatoid arthritis (RA) are associated with high frequencies of CD4+CD28- T cells. The number of these cells is genetically determined and may also be a consequence of chronic exposure to tumor necrosis factor-alpha (TNFalpha). The aim of this study was to examine whether the r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0374-4
更新日期:2004-11-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04602-8
更新日期:2020-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541214
更新日期:1984-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scar...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-10-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) patients have high risk for anxiety and depression. We aimed to investigate the prevalence and risk factors of anxiety and depression in SLE patients in Southwest China. Participants were recruited by convenience sampling from Rheumatic Outpatient Clinic of West China Hospital Sichua...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3559-3
更新日期:2016-12-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541245
更新日期:1982-01-01 00:00:00
abstract::We studied the relationships between physician-assessed damage, severity and activity in a large, multicentre systemic sclerosis (SSc, scleroderma) cohort. We hypothesized that there is a relationship between disease activity and severity and damage, but that severity would be more strongly related to damage. A total ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1129-7
更新日期:2010-07-01 00:00:00