Abstract:
:To assess the prognostic value of scleroderma pattern of nailfold capillary changes for the development of connective tissue diseases (CTD) in subjects with primary Raynaud's phenomenon (RP). The study included 3,029 consecutive patients with primary RP who had been followed at 6-month intervals during the mean of 4.8 years. The pathological features of nailfold capillaroscopy were recorded in all patients who had neither clinical nor serological signs of a CTD. In patients who developed CTD, capillary changes obtained 6 months prior to diagnosis were analyzed. A possible relationship between capillary changes and the presence of associated CTD was assessed. At the end of follow-up, 1,660 (54,8%) patients have still the primary RP, 246 (8,1%) had suspected secondary RP, and 1,123 (37,1%) patients developed CTD (363 undifferentiated CTD, 263 systemic sclerosis, 143 systemic lupus erythematosus, 106 rheumatoid arthritis, 102 Sjögren's syndrome, 61 overlap syndrome, 30 vasculitides, 24 mixed CTD, 19 polymyositis, 7 dermatomyositis, and 5 primary antiphospholipid syndrome). Scleroderma pattern were significantly associated with the development of systemic sclerosis [P = .00001, sensitivity 94%, specificity 92%, positive predictive value 52%, negative predictive value 99%, and odds ratio 163 (95% CI, 97,9-271,5)], as well as dermatomyositis (P = .0004), overlap syndrome with signs of systemic sclerosis (P = .0001), and mixed connective tissue disease (P = .007). Capillary microscopy is effective method for differentiation between primary and secondary RP and useful tool for the prediction of scleroderma spectrum disorders in RP patients.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Pavlov-Dolijanovic S,Damjanov NS,Stojanovic RM,Vujasinovic Stupar NZ,Stanisavljevic DMdoi
10.1007/s00296-011-2109-2subject
Has Abstractpub_date
2012-10-01 00:00:00pages
3039-45issue
10eissn
0172-8172issn
1437-160Xjournal_volume
32pub_type
杂志文章abstract::The objective of this study is to investigate the relationship between clinical features of ankylosing spondylitis (AS) and HLA-B27 status or its subtypes. Clinical data and blood samples were collected with patients' informed consent. Luminex liquid array combining polymerase chain reaction-sequence specific oligonuc...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0743-0
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationships among bone mineral densities (BMD) in the calcaneus and leg activity of daily living (L-ADL) in rheumatoid arthritis (RA) patients. METHODS:We measured and compared calcaneus BMD using single X-ray absorptiometry and lumbar spine and femoral neck BM...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0421-1
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abstract::Paleopathological representations of hypermobility syndrome were assumed in pre-Columbian artifacts from different ancient civilizations from America. Anthropomorphic sculptures from several museums and galleries visited on site or thru Internet show the human figure in contorted positions. These positions are only po...
journal_title:Rheumatology international
pub_type: 历史文章,杂志文章
doi:10.1007/s00296-011-2007-7
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abstract::The study includes a case report and a literature review. The main objective of this study is to present a case of spondylodiscitis due to a fungal pathogen, Blastoschizomyces capitatus and to review the published literature on this emergent fungus in etiology of spondylodiscitis, and osteomyelitis. Osteoarticular inv...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-009-0928-1
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abstract::Different genetic variants in estrogen receptor alpha (ESR1) have been shown to influence bone phenotypes including quantitative bone ultrasound in elderly. We aimed to investigate the role of ESR1 polymorphisms in bone mass assessed by calcaneal quantitative ultrasound (QUS) in a population of young adults. The study...
journal_title:Rheumatology international
pub_type: 杂志文章
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abstract::Uveitis is an important component of many rheumatic diseases. The main causes of recurrent uveitis are seronegative spondylarthropathies and Behçet's disease. We describe a rare case of Henoch Schönlein vasculitis (HSV) along with multiple recurrences of acute anterior uveitis. In cases of skin rash and recurrent ante...
journal_title:Rheumatology international
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doi:10.1007/s00296-009-1074-5
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04776-1
更新日期:2021-01-16 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0324-7
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541164
更新日期:1982-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0723-4
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0460-2
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0988-2
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0013-3
更新日期:2006-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 评论,信件
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0406-0
更新日期:2004-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2437-x
更新日期:2013-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2812-2
更新日期:2013-11-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1195-x
更新日期:2010-11-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00262090
更新日期:1995-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0479-2
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pub_type: 临床试验,杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2937-3
更新日期:2014-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00