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A comparative analysis of serologic parameters and oxidative stress in osteoarthritis and rheumatoid arthritis: reply to Mishra and colleagues.

Abstract：

:In chronic diseases such as rheumatoid arthritis and osteoarthritis, the progression of the disease is characterized by stress oxidative, inflammation, and elevated levels of cholesterol. In mevalonate kinase deficiency, an auto-inflammatory disease, the correlation between inflammation and cholesterol levels is opposite. The metabolic pathway that underlies the production of cholesterol is the mevalonate pathway; it is also essential for the biosynthesis of isoprenoids involved in the control of several cell functions. This divergence of cholesterol levels, associated with these two inflammatory disorders, is probably due to a different etiology, pathogenesis, and progression.

journal_name

Rheumatol Int

journal_title

Rheumatology international

authors

Girardelli M,Bianco AM,Marcuzzi A,Crovella S

doi

10.1007/s00296-012-2436-y

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2445-6

issue

9

eissn

0172-8172

issn

1437-160X

journal_volume

33

pub_type

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