TGF-β signal transduction pathways and osteoarthritis.


:Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.


Rheumatol Int


Zhai G,Doré J,Rahman P




Has Abstract


2015-08-01 00:00:00












  • HIV infection and shoulder pain: a challenging case.

    abstract::With better understanding of the pathogenesis of AIDS and the advent of anti-retroviral medications, patients with HIV are living longer and the probability that they will suffer musculoskeletal complications are increasing. There is a vast array of musculoskeletal impairments including rheumatologic, infectious, and ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Atalay A,Ozdemir O,Guven GS,Başgöze O

    更新日期:2006-05-01 00:00:00

  • Comparison of modern marker proteins in serum and synovial fluid in patients with advanced osteoarthrosis and rheumatoid arthritis.

    abstract::Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial flu...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Andereya S,Streich N,Schmidt-Rohlfing B,Mumme T,Müller-Rath R,Schneider U

    更新日期:2006-03-01 00:00:00

  • The demographic and clinical spectrum of Arab versus Asian patients with ankylosing spondylitis in the UAE.

    abstract::Ankylosing spondylitis is a rather uncommon condition in the UAE. Over a period of 10 years. 28 hospital-based patients diagnosed as having AS were retrospectively studied. They included 17 Arabs and 11 Asians. The onset of AS in most patients in this study was in adulthood (mean age at onset was 27.7 years in Arabs a...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: al Attia HM,Sherif AM,Hossain MM,Ahmed YH

    更新日期:1998-01-01 00:00:00

  • Multiple abnormalities in immunoregulatory function of synovial compartment T cells in patients with rheumatoid arthritis. Recognition of a helper augmentation effect.

    abstract::Analyses of the synovial tissue and fluid T lymphocytes obtained from patients with rheumatoid arthritis revealed multiple functional defects in the regulation of autologous blood B cell differentiation into cells secreting immunoglobulin. These abnormalities were not found in peripheral blood T lymphocytes from the s...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Romain PL,Burmester GR,Enlow RW,Winchester RJ

    更新日期:1982-01-01 00:00:00

  • Lower extremity lipedema, upper extremity lipodystrophy and severe calcinosis complicating juvenile dermatomyositis.

    abstract::Juvenile dermatomyositis (JDM) is a rare but complex and potentially life-threatening autoimmune disease of childhood. Significant proportions of patients have residual weakness, muscle atrophy, joint contractures, and calcinosis. Recently, new clinical findings, such as lipodystrophy accompanied with increased fat de...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Pavlov-Dolijanovic SR,Vujasinovic Stupar NZ,Gavrilov N,Seric S

    更新日期:2014-11-01 00:00:00

  • Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus.

    abstract::Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodi...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Chitrabamrung S,Rubin RL,Tan EM

    更新日期:1981-01-01 00:00:00

  • Crystalglobulinemia manifested as acute renal failure and thrombotic vasculopathy.

    abstract::Crystalglobulinemia is an extremely rare pathology that is associated in most cases with plasma cell dyscrasia, mainly multiple myeloma. In most cases, it may be the manifestation of incipient gammopathy or it manifests shortly after diagnosis. We report a patient with ischemic lesions of thrombotic origin in lower li...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Gómez-Lechón Quirós L,Acosta De La Vega ME,Compán Fernández O,Pastor Navarro S,Montilla Morales C,Moyano Bueno D,Martín Centellas J,Santos-Briz Terrón A,Hidalgo Calleja C

    更新日期:2020-08-01 00:00:00

  • CT assessment of axillary lymphadenopathy in patients with rheumatoid arthritis: association with disease activity and severity.

    abstract:BACKGROUND:Axillary lymph nodes (ALNs) are often seen on chest computed tomography (CT) in rheumatoid arthritis (RA) patients. Early reports described lymphadenopathy as one of the systemic manifestations rather than regional lymphadenopathy secondary to drainage from the affected joints. Subsequently, the importance o...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Hasegawa M,Sakai F,Konda N,Okabayashi A,Katsura H,Seto Y

    更新日期:2018-06-01 00:00:00

  • Regional migratory osteoporosis: case report of a patient with neuropathic pain.

    abstract::Regional migratory osteoporosis (RMO) is an idiopathic disorder characterized by severe periarticular pain, transient and migratory arthralgia, and osteoporosis. Osteoporosis in this disease may appear in the form of local regional osteoporosis and bone marrow edema or generalized osteoporosis. It occurs most commonly...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kartal E,Sahin E,Dilek B,Baydar M,Manisali M,Kosay C,Gulbahar S

    更新日期:2011-10-01 00:00:00

  • Calcaneus bone mineral density in Japanese women with rheumatoid arthritis.

    abstract:OBJECTIVES:The aim of this study was to investigate the relationships among bone mineral densities (BMD) in the calcaneus and leg activity of daily living (L-ADL) in rheumatoid arthritis (RA) patients. METHODS:We measured and compared calcaneus BMD using single X-ray absorptiometry and lumbar spine and femoral neck BM...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Doi S,Kushida K,Miyamoto S,Sekioka Y,Suzuki M,Inoue T,Nagano A

    更新日期:2005-04-01 00:00:00

  • Clinical presentation, treatment and outcome of Takayasu's arteritis in southern Chinese: a multicenter retrospective study.

    abstract::To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...

    journal_title:Rheumatology international

    pub_type: 杂志文章,多中心研究


    authors: Wong SPY,Mok CC,Lau CS,Yip ML,Tam LS,Ying KY,Ng WL,Ng KH,Leung MH,Lee TY,To CH,Lee KL,Wan MC,Yu KL,Wong PCH,Sung CK,Lee KF,Kun EWL,Hong Kong Takayasu’s arteritis study group.

    更新日期:2018-12-01 00:00:00

  • The nature of the onset of rheumatoid arthritis: a reassessment.

    abstract::A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Halla JT,Hardin JG,Fallahi S

    更新日期:1987-01-01 00:00:00

  • Adherence to best practice consensus guidelines for familial Mediterranean fever: a modified Delphi study among paediatric rheumatologists in Turkey.

    abstract:BACKGROUND:Although not validated fully, recommendations are present for diagnosis, screening and treatment modalities of patients with familial Mediterranean fever (FMF). OBJECTIVE:To review the current practices of clinicians regarding FMF and reveal their adherence to consensus guidelines. METHODS:Fifteen key poin...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kavrul Kayaalp G,Sozeri B,Sönmez HE,Demir F,Cakan M,Oztürk K,Karadag SG,Otar Yener G,Ozdel S,Baglan E,Celikel E,Sahin N,Gezgin Yildirim D,Eker Omeroglu R,Aktay Ayaz N,PeRA-Research Group.

    更新日期:2021-01-16 00:00:00

  • Noninvasive assessment of impaired endothelial dysfunction in mucocutaneous Behçet's disease.

    abstract::Noninvasive assessment of endothelial dysfunction (ED) and diagnosing the early vascular development of atherosclerosis in active mucocutaneous Behçet's disease. Twenty-nine active BD patients (study group) without any obstructive vascular involvement were compared with twenty-nine healthy controls (control group) in ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ulusoy RE,Karabudak O,Kilicaslan F,Kirilmaz A,Us MH,Cebeci BS

    更新日期:2008-05-01 00:00:00

  • Coexistence of familial Mediterranean fever and psoriasis in a patient with seronegative spondyloarthropathy.

    abstract::Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bodur H,Seçkin U,Eser F,Ergül G,Seçkin S

    更新日期:2008-11-01 00:00:00

  • Long-term safety and efficacy of low-dose cyclosporin A in severe psoriatic arthritis.

    abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and tolerability of long-term treatment with cyclosporin A (CsA) in patients with psoriatic arthritis (PsA). METHODS:Sixty patients with PsA were enrolled in a prospective, nonrandomised study of CsA. Patients with hypertension or hypercreatinemia were exclu...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章


    authors: Sarzi-Puttini P,Cazzola M,Panni B,Turiel M,Fiorini T,Belai-Beyene N,Chèrié-Lignièré EL

    更新日期:2002-04-01 00:00:00

  • The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards Ia and monocyte-macrophage antigens.

    abstract::Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Burmester GR,Locher P,Koch B,Winchester RJ,Dimitriu-Bona A,Kalden JR,Mohr W

    更新日期:1983-01-01 00:00:00

  • Identification and purification of a 55K polypeptide in Sjögren's syndrome A antigen.

    abstract::The Sjögren's syndrome A antigen (SS-A) purified by affinity chromatography from human spleen was shown to contain a major polypeptide with a mol. wt. of 55 000 daltons confirmed as SS-A by its reactivity with different anti-SS-A sera on affinity columns, immunodiffusion and the Western blot. A similar reactive polype...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Smith PR,Venables PJ,Williams D,Maini RN

    更新日期:1984-01-01 00:00:00

  • Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis.

    abstract::The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis. One hundred and sixty-nine patients, aged between 22 and 70 years...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Martín-Mola E,Gijón-Baños J,Ansoleaga JJ

    更新日期:1995-01-01 00:00:00

  • The effect of coffee, tea, and caffeine consumption on serum uric acid and the risk of hyperuricemia in Korean Multi-Rural Communities Cohort.

    abstract::Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in humans. There is a lack of comprehensive population data for the effects of caffeine intake on urate metabolism. Therefore, the aim of this study was to determine whether coffee, tea, and caffeine intake influences se...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bae J,Park PS,Chun BY,Choi BY,Kim MK,Shin MH,Lee YH,Shin DH,Kim SK

    更新日期:2015-02-01 00:00:00

  • Impact of COVID-19 pandemic on rheumatoid arthritis from a Multi-Centre patient-reported questionnaire survey: influence of gender, rural-urban gap and north-south gradient.

    abstract::During the coronavirus disease-2019 (COVID-19) pandemic there were several barriers to treatment access and medication adherence in rheumatoid arthritis (RA) patients. There is no information regarding the RA patient health status in Egypt during the COVID-19. Thus,the aim of this work was to study the impact of the p...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Abualfadl E,Ismail F,Shereef RRE,Hassan E,Tharwat S,Mohamed EF,Abda EA,Radwan AR,Fawzy RM,Moshrif AH,Noor RA,Senara S,Elazim MIA,Abaza NM,Raafat HA,El-Gazzar II,El-Hammady DH,Hammam N,Gheita TA,El-Mallah R,ECR COV

    更新日期:2021-02-01 00:00:00

  • A comparative evaluation of health related quality of life and depression in patients with fibromyalgia syndrome and rheumatoid arthritis.

    abstract::The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Tander B,Cengiz K,Alayli G,Ilhanli I,Canbaz S,Canturk F

    更新日期:2008-07-01 00:00:00

  • Do Heberden and Bouchard nodes affect finger dexterity in elderly?

    abstract::Elderly often have Heberden nodes (HN) and Bouchard nodes (BN) that may affect finger dexterity. The aim of this cross-sectional study was to assess an effect of HN and BN on finger dexterity of the elderly. The nine-hole peg test was used for dexterity measurement in 200 elderly with HN and/or BN. Mean age was 68.6 +...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kitisomprayoonkul W,Promsopa K,Chaiwanichsiri D

    更新日期:2010-02-01 00:00:00

  • Osteoarthritis and the impact on quality of life health indicators.

    abstract::The purpose of this study was to compare quality of life health identifiers in patients with and without osteoarthritis (OA) while controlling for the potentially confounding variables of gender, age, race, education, and income. Data were obtained for comparison from the Behavioral Risk Factor Surveillance System (BR...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Cook C,Pietrobon R,Hegedus E

    更新日期:2007-02-01 00:00:00

  • Measurement properties of Portuguese-Brazil Western Ontario and McMaster Universities osteoarthritis index (WOMAC) for the assessment of knee complaints in Brazilian adults: ELSA-Brasil Musculoskeletal cohort.

    abstract::Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test-retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese-Brazil WOMAC ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lage PTS,Machado LAC,Barreto SM,de Figueiredo RC,Telles RW

    更新日期:2020-02-01 00:00:00

  • A meta-analysis of the association of IL-6 -174 G/C and -572 G/C polymorphisms with systemic lupus erythematosus risk.

    abstract::The results from previous studies on association of IL-6 -174 G/C and -572 G/C polymorphisms with the risk of systemic lupus erythematosus (SLE) remained inconsistent. Therefore, a meta-analysis was performed to assess the association between these two polymorphisms and SLE susceptibility. A literature-based search wa...

    journal_title:Rheumatology international

    pub_type: 杂志文章,meta分析,评审


    authors: Yang Z,Liang Y,Qin B,Zhong R

    更新日期:2014-02-01 00:00:00

  • Polymyalgia rheumatica and risk of coronary artery disease: a systematic review and meta-analysis of observational studies.

    abstract::Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are associated with an increased risk of coronary artery disease (CAD) as a result of accelerated atherosclerosis. However, the data on CAD risk of polymyalgia rheumatica (PMR), one of the most common chronic inflamm...

    journal_title:Rheumatology international

    pub_type: 杂志文章,meta分析,评审


    authors: Ungprasert P,Koster MJ,Warrington KJ,Matteson EL

    更新日期:2017-01-01 00:00:00

  • Clinical spectrum and therapeutics in Canadian patients with anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis: a case-based review.

    abstract::The objective of the study was to determine the clinical features and treatment course in Canadian patients with dermatomyositis (DM) associated with the anti-melanoma differentiation-associated gene 5 antibody (MDA5). A retrospective chart review of consecutive patients with anti-MDA5 antibody DM from two Canadian te...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Huang K,Vinik O,Shojania K,Yeung J,Shupak R,Nimmo M,Avina-Zubieta JA

    更新日期:2019-11-01 00:00:00

  • Pulsed electromagnetic fields decrease proinflammatory cytokine secretion (IL-1β and TNF-α) on human fibroblast-like cell culture.

    abstract::The clinical use of pulsed electromagnetic fields (PEMF) in osteoarticular pathology is widely extended, although the mechanisms involved are unknown. The aim of this study was to evaluate the action of a new protocol of treatment with PEMF on liquid medium cultures of fibroblast-like cells derivates of mononuclear pe...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Gómez-Ochoa I,Gómez-Ochoa P,Gómez-Casal F,Cativiela E,Larrad-Mur L

    更新日期:2011-10-01 00:00:00

  • Interference of cartilage surface with interaction of granulocyte elastase with alpha 1-proteinase inhibitor. An in vitro model of enzyme inhibition in the joint space.

    abstract::Synovial fluids of patients suffering from rheumatoid arthritis contain elevated levels of granulocyte (PMN) elastase in complex with alpha 1-proteinase inhibitor (alpha 1-PI), whereas free-elastase activity is usually not detectable. This absence of free enzymatic activity in joint effusions has cast some doubt on th...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Burkhardt H,Kasten M,Rauls S,Rehkopf E

    更新日期:1987-01-01 00:00:00