Abstract:
:Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Zhai G,Doré J,Rahman Pdoi
10.1007/s00296-015-3251-zsubject
Has Abstractpub_date
2015-08-01 00:00:00pages
1283-92issue
8eissn
0172-8172issn
1437-160Xjournal_volume
35pub_type
杂志文章,评审abstract::With better understanding of the pathogenesis of AIDS and the advent of anti-retroviral medications, patients with HIV are living longer and the probability that they will suffer musculoskeletal complications are increasing. There is a vast array of musculoskeletal impairments including rheumatologic, infectious, and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0043-x
更新日期:2006-05-01 00:00:00
abstract::Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial flu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0006-2
更新日期:2006-03-01 00:00:00
abstract::Ankylosing spondylitis is a rather uncommon condition in the UAE. Over a period of 10 years. 28 hospital-based patients diagnosed as having AS were retrospectively studied. They included 17 Arabs and 11 Asians. The onset of AS in most patients in this study was in adulthood (mean age at onset was 27.7 years in Arabs a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960050033
更新日期:1998-01-01 00:00:00
abstract::Analyses of the synovial tissue and fluid T lymphocytes obtained from patients with rheumatoid arthritis revealed multiple functional defects in the regulation of autologous blood B cell differentiation into cells secreting immunoglobulin. These abnormalities were not found in peripheral blood T lymphocytes from the s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541164
更新日期:1982-01-01 00:00:00
abstract::Juvenile dermatomyositis (JDM) is a rare but complex and potentially life-threatening autoimmune disease of childhood. Significant proportions of patients have residual weakness, muscle atrophy, joint contractures, and calcinosis. Recently, new clinical findings, such as lipodystrophy accompanied with increased fat de...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3031-1
更新日期:2014-11-01 00:00:00
abstract::Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541153
更新日期:1981-01-01 00:00:00
abstract::Crystalglobulinemia is an extremely rare pathology that is associated in most cases with plasma cell dyscrasia, mainly multiple myeloma. In most cases, it may be the manifestation of incipient gammopathy or it manifests shortly after diagnosis. We report a patient with ischemic lesions of thrombotic origin in lower li...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-020-04620-6
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Axillary lymph nodes (ALNs) are often seen on chest computed tomography (CT) in rheumatoid arthritis (RA) patients. Early reports described lymphadenopathy as one of the systemic manifestations rather than regional lymphadenopathy secondary to drainage from the affected joints. Subsequently, the importance o...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3992-6
更新日期:2018-06-01 00:00:00
abstract::Regional migratory osteoporosis (RMO) is an idiopathic disorder characterized by severe periarticular pain, transient and migratory arthralgia, and osteoporosis. Osteoporosis in this disease may appear in the form of local regional osteoporosis and bone marrow edema or generalized osteoporosis. It occurs most commonly...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1256-1
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationships among bone mineral densities (BMD) in the calcaneus and leg activity of daily living (L-ADL) in rheumatoid arthritis (RA) patients. METHODS:We measured and compared calcaneus BMD using single X-ray absorptiometry and lumbar spine and femoral neck BM...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0421-1
更新日期:2005-04-01 00:00:00
abstract::To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-4150-x
更新日期:2018-12-01 00:00:00
abstract::A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270365
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Although not validated fully, recommendations are present for diagnosis, screening and treatment modalities of patients with familial Mediterranean fever (FMF). OBJECTIVE:To review the current practices of clinicians regarding FMF and reveal their adherence to consensus guidelines. METHODS:Fifteen key poin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04776-1
更新日期:2021-01-16 00:00:00
abstract::Noninvasive assessment of endothelial dysfunction (ED) and diagnosing the early vascular development of atherosclerosis in active mucocutaneous Behçet's disease. Twenty-nine active BD patients (study group) without any obstructive vascular involvement were compared with twenty-nine healthy controls (control group) in ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0491-6
更新日期:2008-05-01 00:00:00
abstract::Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0616-6
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and tolerability of long-term treatment with cyclosporin A (CsA) in patients with psoriatic arthritis (PsA). METHODS:Sixty patients with PsA were enrolled in a prospective, nonrandomised study of CsA. Patients with hypertension or hypercreatinemia were exclu...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-001-0166-7
更新日期:2002-04-01 00:00:00
abstract::Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541597
更新日期:1983-01-01 00:00:00
abstract::The Sjögren's syndrome A antigen (SS-A) purified by affinity chromatography from human spleen was shown to contain a major polypeptide with a mol. wt. of 55 000 daltons confirmed as SS-A by its reactivity with different anti-SS-A sera on affinity columns, immunodiffusion and the Western blot. A similar reactive polype...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541183
更新日期:1984-01-01 00:00:00
abstract::The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis. One hundred and sixty-nine patients, aged between 22 and 70 years...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF00302127
更新日期:1995-01-01 00:00:00
abstract::Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in humans. There is a lack of comprehensive population data for the effects of caffeine intake on urate metabolism. Therefore, the aim of this study was to determine whether coffee, tea, and caffeine intake influences se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3061-8
更新日期:2015-02-01 00:00:00
abstract::During the coronavirus disease-2019 (COVID-19) pandemic there were several barriers to treatment access and medication adherence in rheumatoid arthritis (RA) patients. There is no information regarding the RA patient health status in Egypt during the COVID-19. Thus,the aim of this work was to study the impact of the p...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04736-9
更新日期:2021-02-01 00:00:00
abstract::The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0551-6
更新日期:2008-07-01 00:00:00
abstract::Elderly often have Heberden nodes (HN) and Bouchard nodes (BN) that may affect finger dexterity. The aim of this cross-sectional study was to assess an effect of HN and BN on finger dexterity of the elderly. The nine-hole peg test was used for dexterity measurement in 200 elderly with HN and/or BN. Mean age was 68.6 +...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1196-9
更新日期:2010-02-01 00:00:00
abstract::The purpose of this study was to compare quality of life health identifiers in patients with and without osteoarthritis (OA) while controlling for the potentially confounding variables of gender, age, race, education, and income. Data were obtained for comparison from the Behavioral Risk Factor Surveillance System (BR...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0269-2
更新日期:2007-02-01 00:00:00
abstract::Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test-retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese-Brazil WOMAC ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04496-1
更新日期:2020-02-01 00:00:00
abstract::The results from previous studies on association of IL-6 -174 G/C and -572 G/C polymorphisms with the risk of systemic lupus erythematosus (SLE) remained inconsistent. Therefore, a meta-analysis was performed to assess the association between these two polymorphisms and SLE susceptibility. A literature-based search wa...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00296-013-2855-4
更新日期:2014-02-01 00:00:00
abstract::Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are associated with an increased risk of coronary artery disease (CAD) as a result of accelerated atherosclerosis. However, the data on CAD risk of polymyalgia rheumatica (PMR), one of the most common chronic inflamm...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00296-016-3557-5
更新日期:2017-01-01 00:00:00
abstract::The objective of the study was to determine the clinical features and treatment course in Canadian patients with dermatomyositis (DM) associated with the anti-melanoma differentiation-associated gene 5 antibody (MDA5). A retrospective chart review of consecutive patients with anti-MDA5 antibody DM from two Canadian te...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04398-2
更新日期:2019-11-01 00:00:00
abstract::The clinical use of pulsed electromagnetic fields (PEMF) in osteoarticular pathology is widely extended, although the mechanisms involved are unknown. The aim of this study was to evaluate the action of a new protocol of treatment with PEMF on liquid medium cultures of fibroblast-like cells derivates of mononuclear pe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1488-0
更新日期:2011-10-01 00:00:00
abstract::Synovial fluids of patients suffering from rheumatoid arthritis contain elevated levels of granulocyte (PMN) elastase in complex with alpha 1-proteinase inhibitor (alpha 1-PI), whereas free-elastase activity is usually not detectable. This absence of free enzymatic activity in joint effusions has cast some doubt on th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270466
更新日期:1987-01-01 00:00:00