TGF-β signal transduction pathways and osteoarthritis.

Abstract:

:Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.

journal_name

Rheumatol Int

authors

Zhai G,Doré J,Rahman P

doi

10.1007/s00296-015-3251-z

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

1283-92

issue

8

eissn

0172-8172

issn

1437-160X

journal_volume

35

pub_type

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