TGF-β signal transduction pathways and osteoarthritis.


:Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.


Rheumatol Int


Zhai G,Doré J,Rahman P




Has Abstract


2015-08-01 00:00:00












  • Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results.

    abstract::The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an excessive regional inflammation, sensitization of primary somatosensory afferents, and sensitization of spinal neurons are considered to have a role in the pathogenesis of RSD. The underlying pathophysiology relating the c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Okudan B,Celik C

    更新日期:2006-03-01 00:00:00

  • Correlates and predictors of paediatric leg pain: a case-control study.

    abstract::Paediatric leg pains, long described as 'growing pains', frequently present to clinicians, are prevalent in early childhood, disrupt sleep, and distress affected children and parents. There are many cited associations, but no defined leg pain sub-types, nor revealed predictive factors. We explored the implicated facto...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Evans AM,Berde T,Karimi L,Ranade P,Shah N,Khubchandani R

    更新日期:2018-07-01 00:00:00

  • Lack of association between mean platelet volume and disease activity in systemic lupus erythematosus patients: a systematic review and meta-analysis.

    abstract::Currently, many studies have focused on the possibility of using mean platelet volume (MPV) as a biomarker for disease activity in patients with systemic lupus erythematosus (SLE). To derive a more accurate estimation, a meta-analysis was conducted. Embase, PubMed, The Cochrane Library database and several Chinese dat...

    journal_title:Rheumatology international

    pub_type: 杂志文章,meta分析


    authors: Zhao CN,Mao YM,Wang P,Guan SY,Sam NB,Li XM,Wang DG,Pan HF

    更新日期:2018-09-01 00:00:00

  • Cardiovascular risk in patients with rheumatoid arthritis: assessment of several traditional risk parameters and a German risk score model.

    abstract::The present cross-sectional data demonstrate cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). The cross-sectional data were part of an interventional trial that included 100 patients with defined RA. Traditional CV risk parameters and risk score calculation for the German population were used to as...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Willers J,Hahn A

    更新日期:2012-12-01 00:00:00

  • Kynurenic acid, an endogenous constituent of rheumatoid arthritis synovial fluid, inhibits proliferation of synoviocytes in vitro.

    abstract::Kynurenic acid is an antagonist of ionotropic glutamate receptors. It has been found that glutamate antagonists inhibit proliferation of different human tumor cells. Since the hyperplasia of synovial fibroblasts is one of the most striking features of inflammatory arthritis, the main goals of this study were detection...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Parada-Turska J,Rzeski W,Zgrajka W,Majdan M,Kandefer-Szerszeń M,Turski W

    更新日期:2006-03-01 00:00:00

  • The sensitivity, specificity and accuracy of anti-citrulline antibody test in diagnosis of rheumatoid arthritis.

    abstract::Citrulline antibody, nowadays, is a new item which has been the center of attention due to its much more specificity to diagnose RA. The aim of the present study was to evaluate the efficacy and accuracy of anti-citrulline antibody test in RA diagnosis among hospitalized patients in Iran. Through a case-control study,...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Abolghasemi S,Gitipour A,Morteza A

    更新日期:2013-04-01 00:00:00

  • Tc-99 m diethylenetriamine-pentaacetic acid (DTPA): is it reliable for assessment of methotrexate-induced cumulative effect on renal filtration in rheumatoid arthritis patients?

    abstract::Methotrexate (MTX) is commonly employed as the initial DMARD used for the treatment of rheumatoid arthritis (RA). We aimed to contribute to the safety profile of MTX by assessing its cumulative effect on renal filtration. A total of 52 RA adult female patients with normal baseline serum creatinine and GFR at the initi...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Amin A,Effat D,Goher N,Ramadan B

    更新日期:2013-12-01 00:00:00

  • Infliximab in two patients with juvenile ankylosing spondylitis.

    abstract::Infliximab, a monoclonal chimeric anti-tumor necrosis factor alpha (anti-TNF-alpha) antibody, was tried in two patients suffering from severe refractory juvenile ankylosing spondylarthritis with disease duration of more than 10 years. To assess the response, validated clinical activity parameters were monitored prospe...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Schmeling H,Horneff G

    更新日期:2004-05-01 00:00:00

  • Pro-brain natriuretic peptide (ProBNP) levels in North Indian children with Kawasaki disease.

    abstract::The diagnosis of Kawasaki disease (KD), a common pediatric vasculitis, is based solely on clinical criteria. There is a need for a robust laboratory marker that can help differentiate KD from other acute, febrile, childhood illnesses and also to predict cardiac involvement. We conducted a cross-sectional study of 25 c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Reddy M,Singh S,Rawat A,Sharma A,Suri D,Rohit MK

    更新日期:2016-04-01 00:00:00

  • Osteoporosis in chronic liver disease: a case-control study.

    abstract::Osteoporosis has become an increasingly recognized complication among patients with chronic liver disease (CLD). The aim of the present study was to assess the prevalence and risk factors of osteoporosis in patients with CLD (primary biliary cirrhosis and chronic viral hepatitis B or C patients) in comparison with a g...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Wariaghli G,Mounach A,Achemlal L,Benbaghdadi I,Aouragh A,Bezza A,El Maghraoui A

    更新日期:2010-05-01 00:00:00

  • Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from Chinese ankylosing spondylitis patients with -308G/A polymorphism in promoter region of tumor necrosis factor: association with distinct A33/B58/Cw10 haplotypes.

    abstract::To investigate the effects of TNF-alpha -308, -238 promoter polymorphisms on TNF-alpha transcription in B27 positive Chinese patients with ankylosing spondylitis (AS). The possible relationship between polymorphisms, MHC antigens, and quantitative TNF-alpha mRNA expression were evaluated. Single nucleotide polymorphis...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lu MC,Yang KL,Tung CH,Huang KY,Yu HC,Liu SQ,Lai NS

    更新日期:2008-12-01 00:00:00

  • Compliance with treatment of rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA) is a chronic, progressive, debilitating disease that demands continuous therapy with multiple medications. Noncompliance with disease-modifying drugs may cause disease flares, preventable functional impairment, unnecessary treatment changes, and loss of health care resources. The aim of the c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Müller R,Kallikorm R,Põlluste K,Lember M

    更新日期:2012-10-01 00:00:00

  • Cardiac mechanics and heart rate variability in patients with systemic sclerosis: the association that we should not miss.

    abstract::We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Zlatanovic M,Tadic M,Celic V,Ivanovic B,Stevanovic A,Damjanov N

    更新日期:2017-01-01 00:00:00

  • Antibodies to Sm and SS-A demonstrated by enzyme immunoassay. Correlation to clinical manifestations and disease activity in patients with systemic lupus erythematosus.

    abstract::Using commercially available antigens, enzyme-linked immunosorbent assays (ELISAs) were set up to demonstrate antibodies of IgG class against Sm and SS-A. Anti-Sm antibodies were demonstrated in 40% of patients with systemic lupus erythematosus (SLE), in 12% of patients with SJögren's syndrome, in 6% of patients with ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Gripenberg M,Teppo AM,Friman C

    更新日期:1991-01-01 00:00:00

  • Higher levels of serum interleukin-35 are associated with the severity of pulmonary fibrosis and Th2 responses in patients with systemic sclerosis.

    abstract::The aim of the study is to investigate the levels of serum interleukin-35 (IL-35) before and after treatment and its relationship with clinical parameters as well as the frequency of different subsets of CD4+ T cells in patients with systemic sclerosis (SSc) to explore the role of IL-35 in the pathogenesis of SSc. The...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Tang J,Lei L,Pan J,Zhao C,Wen J

    更新日期:2018-08-01 00:00:00

  • Screening for celiac disease, by endomysial antibodies, in patients with unexplained articular manifestations.

    abstract::Celiac disease (CD) is an autoimmune systemic disease characterized by not only gastrointestinal but also extraintestinal manifestations. The aim of our study was to do a serological screening for CD, by IgA endomysial antibodies (EmA), in patients with unexplained articular manifestations. Two hundred and eleven pati...

    journal_title:Rheumatology international

    pub_type: 杂志文章,多中心研究


    authors: Ghozzi M,Sakly W,Mankaï A,Bouajina E,Bahri F,Nouira R,Kechrid C,Ghedira I

    更新日期:2014-05-01 00:00:00

  • Imported case of visceral leishmaniasis presenting as pancytopenia in a Norwegian patient treated with methotrexate and etanercept for psoriasis arthritis.

    abstract::We report a case of visceral leishmaniasis in a patient from northern Norway with psoriatic arthritis treated with a combination of etanercept and methotrexate. The patient resided extensively in southern Spain, a zone endemic for leishmania. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Besada E,Njålla RJ,Nossent JC

    更新日期:2013-10-01 00:00:00

  • Interference of cartilage surface with interaction of granulocyte elastase with alpha 1-proteinase inhibitor. An in vitro model of enzyme inhibition in the joint space.

    abstract::Synovial fluids of patients suffering from rheumatoid arthritis contain elevated levels of granulocyte (PMN) elastase in complex with alpha 1-proteinase inhibitor (alpha 1-PI), whereas free-elastase activity is usually not detectable. This absence of free enzymatic activity in joint effusions has cast some doubt on th...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Burkhardt H,Kasten M,Rauls S,Rehkopf E

    更新日期:1987-01-01 00:00:00

  • Hypothermia induced by adenosine 5'-monophosphate attenuates early stage injury in an acute gouty arthritis rat model.

    abstract::To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Miao Z,Guo W,Lu S,Lv W,Li C,Wang Y,Zhao S,Yan S,Tao Z,Wang Y

    更新日期:2013-08-01 00:00:00

  • Stability of fatigue, pain, patient global assessment and the Bath Ankylosing Spondylitis Functional Index (BASFI) in spondyloarthropathy patients with stable disease according to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).

    abstract::The study objective was to examine natural variation of the patient-reported outcome measures fatigue, pain, patient global assessment (PaGl) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in patients with stable axial spondyloarthropathy (ax-SpA) defined on the basis of the Bath Spondylitis Ankylosing D...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Madsen OR

    更新日期:2018-03-01 00:00:00

  • Paleopathological interpretations of hypermobility syndrome in the art from ancient America.

    abstract::Paleopathological representations of hypermobility syndrome were assumed in pre-Columbian artifacts from different ancient civilizations from America. Anthropomorphic sculptures from several museums and galleries visited on site or thru Internet show the human figure in contorted positions. These positions are only po...

    journal_title:Rheumatology international

    pub_type: 历史文章,杂志文章


    authors: Checa A

    更新日期:2012-10-01 00:00:00

  • Impairment measures in rheumatic disorders for rehabilitation medicine and allied health care: a systematic review.

    abstract:UNLABELLED:The objective of this study is to provide a critical overview of available instruments to assess impairments in patients with rheumatic disorders, and to recommend reliable and valid instruments for use in allied health care and rehabilitation medicine. A computer-aided literature search (1982-2004) in sever...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Swinkels RA,Bouter LM,Oostendorp RA,van den Ende CH

    更新日期:2005-09-01 00:00:00

  • Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway.

    abstract::Resveratrol (trans-3,4'-trihydroxystilbene), a natural phytoalexin, possesses anti-inflammatory, anti-proliferative, and immunomodulatory properties and has the potential for treating inflammatory disorders. The present study was designed to investigate the effects of resveratrol on TNF-α-induced inflammatory cytokine...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Tian J,Chen JW,Gao JS,Li L,Xie X

    更新日期:2013-07-01 00:00:00

  • Clinical manifestations and outcomes of musculoskeletal nontuberculous mycobacterial infections.

    abstract::To investigate the clinical manifestations and outcomes of musculoskeletal (MSK) nontuberculous mycobacterium (NTM) infections. This study was a retrospective cohort study using the Siriraj Hospital database from 2005 to 2017. Enrolled were all patients aged 15 or older who had an MSK infection with NTM identified in ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Napaumpaiporn C,Katchamart W

    更新日期:2019-10-01 00:00:00

  • Elevated serum Krebs von den Lungen-6 in systemic sclerosis: a marker of lung fibrosis and severity of the disease.

    abstract:OBJECTIVES:We aimed to assess the clinical significance of Krebs von den Lungen-6 (KL-6) in the diagnosis and severity of interstitial lung disease (ILD) in a French cohort of patients with systemic sclerosis (SSc). METHODS:Serum KL-6 concentrations were measured with chemiluminescent enzyme immunoassay (CLEIA) in 75 ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Benyamine A,Heim X,Resseguier N,Bertin D,Gomez C,Ebbo M,Harlé JR,Kaplanski G,Rossi P,Bardin N,Granel B

    更新日期:2018-05-01 00:00:00

  • Synovial fluid levels of E-selectin and intercellular adhesion molecule-1: relationship to joint inflammation in children with chronic arthritis.

    abstract::E-selectin and intercellular adhesion molecule (ICAM)-1 are crucial to the inflammatory response in chronic inflammatory arthritis. Soluble (s) levels of these molecules in sera and synovial fluid (SF) correlate with some clinical parameters and synovial tissue expression of the same molecules in rheumatoid arthritis....

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bloom BJ,Nelson SM,Alario AJ,Miller LC,Schaller JG

    更新日期:2002-09-01 00:00:00

  • Outcome of Boyd-McLeod procedure for recalcitrant lateral epicondylitis of elbow.

    abstract::Various surgical procedures including percutaneous and open release and arthroscopic procedures have been described to treat recalcitrant tennis elbow. We present the outcome of Boyd-McLeod surgical procedure for tennis elbow resistant to non-operative treatment in twenty-seven patients (twenty-nine limbs). Boyd McLeo...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Reddy VR,Satheesan KS,Bayliss N

    更新日期:2011-08-01 00:00:00

  • Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.

    abstract::We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA). The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar sp...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Atalay A,Altaykan A,Ergin G,Kutsal YG

    更新日期:2004-09-01 00:00:00

  • Cytokine profile in serum and synovial fluid of arthritis patients with Chlamydia trachomatis infection.

    abstract::Chlamydia trachomatis (Ct)-induced arthritis (CtIA) is characterized by persistent Ct infection, which stimulates secretion of cytokines in vitro. We therefore investigated whether CtIA patients have a unique cytokine profile in synovial fluid or serum in vivo. Because underlying Ct infection is overlooked in a high p...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Jendro MC,Raum E,Schnarr S,Köhler L,Zeidler H,Kuipers JG,Martin M

    更新日期:2005-01-01 00:00:00

  • Magnetic resonance imaging of palindromic rheumatism.

    abstract::A 44-year-old man with intermittent asymmetric migratory oligoarthritis lasting the recent decade was admitted to our hospital. Considerable specific biomarkers for rheumatoid arthritis such as anti-agalactosyl IgG antibody are all negative. He was diagnosed as palindromic rheumatism (PR). Although hand X-rays showed ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ueda S,Horino T,Arii K,Morita T,Takao T,Hashimoto K

    更新日期:2008-11-01 00:00:00