Abstract：
:Splenectomy may be necessary to treat systemic lupus erythematosus (SLE) patients with thrombocytopenia; however, whether performing a splenectomy on patients without SLE increases the subsequent risk of SLE remains unknown. Therefore, this study was conducted to determine the association between splenectomy and SLE. We conducted a cohort study by using data from the Taiwan National Health Institute Research Database to identify 10,298 patients with received a splenectomy between 2000 and 2006 and 41,192 participants without received a splenectomy who were selected by frequency matched based on sex, age, and the index year. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs) of developing SLE associated with splenectomy compared with patients who did not receive a splenectomy. During the study period, the overall incidence density rate of SLE was higher in the splenectomy cohort than in the non-splenectomy cohort (adjusted HR 10.55; 95 % CI 50.55-20.05). The incidence density rates of SLE in women and men who received a splenectomy were higher than those of patients who did not receive a splenectomy. Non-traumatic splenectomy increases the subsequent risk of SLE. The risk of SLE should be considered before performing a splenectomy, particularly in women and younger patients.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Hsu CY,Chen HJ,Hsu CY,Kao CHdoi
10.1007/s00296-015-3388-9subject
Has Abstractpub_date
2016-02-01 00:00:00pages
271-6issue
2eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-015-3388-9journal_volume
36pub_type
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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