The association of anti-CCP antibodies with disease activity in rheumatoid arthritis.

Abstract:

:Antibodies to citrullinated proteins have been described in patients with rheumatoid arthritis (RA) and these appear to be the most specific markers of the disease. Our objective was to determine the frequency of antibodies to cyclic citrullinated peptides (CCPs) in patients with RA and the association of anti-CCP antibodies with disease activity, radiological erosions and HLA DR genotype. Forty patients with RA and 38 patients with fibromyalgia were included in this study. Serum samples were collected from both patient groups with RA and fibromyalgia. Anti-CCP was measured by the corresponding enzyme-linked immunosorbent assay. Additionally, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), disease activity score (DAS), visual analog scala (VAS), HLA genotype and radiographic information were determined in patients with RA. The rate of sensitivity and specificity of anti-CCP reactivity for the diagnosis RA were measured (sensitivity 50%, specificity 100%). There is no significant difference between anti-CCP (+) and anti-CCP (-) RA patients for DAS28, VAS, ESR, CRP, disease duration, HLA genotype, and radiological assessment of hand. However, there was a significant difference between anti-CCP (+) and anti-CCP (-) RA patients for RF and the radiological assessment of left and right wrists (respectively, P < 0.05, P = 0.04, P = 0.01). There was no significant correlation between anti-CCP antibody and ESR, CRP, VAS, DAS 28 or radiological assessment. A small but significant correlation was found between RF and anti-CCP antibody (P = 0.02, r = 0.35).

journal_name

Rheumatol Int

authors

Serdaroğlu M,Cakirbay H,Değer O,Cengiz S,Kul S

doi

10.1007/s00296-008-0570-3

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

965-70

issue

10

eissn

0172-8172

issn

1437-160X

journal_volume

28

pub_type

杂志文章
  • A comparative evaluation of health related quality of life and depression in patients with fibromyalgia syndrome and rheumatoid arthritis.

    abstract::The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-008-0551-6

    authors: Tander B,Cengiz K,Alayli G,Ilhanli I,Canbaz S,Canturk F

    更新日期:2008-07-01 00:00:00

  • Iloprost infusion does not reduce oxidative stress in systemic sclerosis.

    abstract::Systemic sclerosis is a connective tissue disease in which oxidative stress represents an important player among the complex pathogenetic mechanisms of the disease. Iloprost, an analogue of natural prostacyclin, is used in systemic sclerosis for the treatment of severe Raynaud's phenomenon and ischemic ulcers. There i...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00296-007-0443-1

    authors: Volpe A,Biasi D,Caramaschi P,Bambara LM,Carletto A,Degan M,Minuz P

    更新日期:2008-02-01 00:00:00

  • Current understanding and future perspectives of brain-heart-kidney axis in psoriatic arthritis.

    abstract::Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA reve...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-020-04633-1

    authors: Markousis-Mavrogenis G,Nurmohamed MT,Koutsogeorgopoulou L,Dimitroulas T,Katsifis G,Vartela V,Mitsikostas D,Kolovou G,Tektonidou M,Voulgari P,Sfikakis PP,Kitas GD,Mavrogeni SI

    更新日期:2020-09-01 00:00:00

  • Outcome of Boyd-McLeod procedure for recalcitrant lateral epicondylitis of elbow.

    abstract::Various surgical procedures including percutaneous and open release and arthroscopic procedures have been described to treat recalcitrant tennis elbow. We present the outcome of Boyd-McLeod surgical procedure for tennis elbow resistant to non-operative treatment in twenty-seven patients (twenty-nine limbs). Boyd McLeo...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1450-1

    authors: Reddy VR,Satheesan KS,Bayliss N

    更新日期:2011-08-01 00:00:00

  • Noninvasive assessment of impaired endothelial dysfunction in mucocutaneous Behçet's disease.

    abstract::Noninvasive assessment of endothelial dysfunction (ED) and diagnosing the early vascular development of atherosclerosis in active mucocutaneous Behçet's disease. Twenty-nine active BD patients (study group) without any obstructive vascular involvement were compared with twenty-nine healthy controls (control group) in ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-007-0491-6

    authors: Ulusoy RE,Karabudak O,Kilicaslan F,Kirilmaz A,Us MH,Cebeci BS

    更新日期:2008-05-01 00:00:00

  • Survival analysis and risk factors for mortality in connective tissue disease-associated pneumomediastinum.

    abstract::The aim of this study was to analyze the characteristics of patients with diffuse connective tissue diseases (CTDs) complicated by pneumomediastinum and identify the risk factors associated with increased mortality in these patients. Twenty-eight patients with CTD-associated pneumomediastinum, who were admitted to our...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-014-3046-7

    authors: Zhang L,Shen M,Zhang F,Tang F

    更新日期:2014-12-01 00:00:00

  • Oxidant/antioxidant status of plasma samples from patients with rheumatoid arthritis.

    abstract::This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s002960050097

    authors: Oztürk HS,Cimen MY,Cimen OB,Kaçmaz M,Durak I

    更新日期:1999-01-01 00:00:00

  • Cross-sectional correlation of single-item health literacy screening questions with established measures of health literacy in patients with rheumatoid arthritis.

    abstract::Research suggests that health literacy (HL) is associated with rheumatoid arthritis (RA) patients' functional status. Single-item health literacy screening (SILS) questionnaires may establish patients' HL; however, the wording of SILS may be misinterpreted by RA patients as a query regarding physical limitations. Desp...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-015-3238-9

    authors: Quinzanos I,Hirsh JM,Bright C,Caplan L

    更新日期:2015-09-01 00:00:00

  • Nailfold videocapillaroscopy in patients with systemic lupus erythematosus.

    abstract::Nailfold videocapillaroscopy was performed in 21 controls (C) and 21 patients (P) with systemic lupus erythematosus (SLE) classified according to the American College of Rheumatology, with, at least, 1 year of diagnosed disease and having low activity (MEX-SLEDAI) and sequel (SLICC) indexes at the time of the examinat...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-005-0033-z

    authors: Dancour MA,Vaz JL,Bottino DA,Bouskela E

    更新日期:2006-05-01 00:00:00

  • Terminal monosaccharide screening of synovial immunoglobulins G and A for the early detection of rheumatoid arthritis.

    abstract::The expressions of some terminal glycotopes of synovial immunoglobulins G, A, and M were analysed in relation to rheumatoid arthritis (RA) progression defined according to early and advanced radiological changes in patients' hands. The relative amounts of terminal monosaccharides were determined by lectin-immunoblotti...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1139-5

    authors: Kratz EM,Borysewicz K,Katnik-Prastowska I

    更新日期:2010-08-01 00:00:00

  • Gait as predictor of physical function in axial spondyloarthritis: the prospective longitudinal FOLOMI (Function, Locomotion, Measurement, Inflammation) study protocol.

    abstract::Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease affecting predominantly sacroiliac joints and axial skeleton. axSpA progression being irregular and hardly predictable, identifying functional decline is particularly important in patient with axSpA to allow delivery of timely and targeted int...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-019-04396-4

    authors: Soulard J,Vuillerme N,Gaudin P,Grange L,Baillet A,Cracowski JL,Juvin R,Vaillant J

    更新日期:2019-10-01 00:00:00

  • Contralateral electroacupuncture pretreatment suppresses carrageenan-induced inflammatory pain via the opioid-mu receptor.

    abstract::Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1 mA, 10 Hz EA ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1364-y

    authors: Yang EJ,Koo ST,Kim YS,Lee JE,Hwang HS,Lee MS,Choi SM

    更新日期:2011-06-01 00:00:00

  • P wave dispersion in patients with rheumatoid arthritis: its relation with clinical and echocardiographic parameters.

    abstract::P wave dispersion (PWD) is a sign for the prediction of atrial fibrillation (AF). The aim of this study was to assess P wave dispersion and its relation with clinical and echocardiographic parameters in patients with rheumatoid arthritis (RA). Thirty RA patients (mean age 49 +/- 10 years) and 27 healthy controls (mean...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-007-0307-8

    authors: Guler H,Seyfeli E,Sahin G,Duru M,Akgul F,Saglam H,Yalcin F

    更新日期:2007-07-01 00:00:00

  • Is psychological distress intrinsic to fibromyalgia syndrome? Cross-sectional analysis in two clinical presentations.

    abstract::Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2199-x

    authors: Salgueiro M,Aira Z,Buesa I,Bilbao J,Azkue JJ

    更新日期:2012-11-01 00:00:00

  • Platelets in the synovial fluid of patients with rheumatoid arthritis.

    abstract::In a study of synovial fluid from 110 patients with various forms of arthritis, platelets were identified in the synovial fluid of all the 50 rheumatoids, in 18 out of the 25 (72%) with osteoarthritis and in all 35 of those with other forms of inflammatory osteoarthrosis. Identification of platelets by light microscop...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF00683878

    authors: Farr M,Wainwright A,Salmon M,Hollywell CA,Bacon PA

    更新日期:1984-01-01 00:00:00

  • Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthritis.

    abstract::To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2282-3

    authors: Esalatmanesh K,Jamali R,Jamali A,Jamali B,Nikbakht M

    更新日期:2012-12-01 00:00:00

  • Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility.

    abstract::A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00296-013-2924-8

    authors: Nakayama A,Matsuo H,Shimizu T,Takada Y,Nakamura T,Shimizu S,Chiba T,Sakiyama M,Naito M,Morita E,Ichida K,Shinomiya N

    更新日期:2014-04-01 00:00:00

  • Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis.

    abstract::This study investigated the prevalence of antibody against annexin II (A2) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored the role of this antibody in thrombosis. Purified recombinant A2 was used in ELISA to measure the levels of IgG anti-A2 antibody in 101 AP...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1379-4

    authors: Ao W,Zheng H,Chen XW,Shen Y,Yang CD

    更新日期:2011-07-01 00:00:00

  • Assessment of sexual functions in female patients with ankylosing spondylitis compared with healthy controls.

    abstract::Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2340-x

    authors: Demir SE,Rezvani A,Ok S

    更新日期:2013-01-01 00:00:00

  • Baseline HAQ and SF-36 questionnaire scores cannot predict clinical remission, radiographic progression or the need for biological therapy in a three-year prospective study of a Brazilian early rheumatoid arthritis cohort.

    abstract::This study evaluates prospectively whether baseline scores [Health Assessment Questionnaire (HAQ) and SF-36] can predict clinical and radiographic evolution in a cohort of early rheumatoid arthritis (RA) during a 3-year follow-up. Forty consecutive early RA patients were followed for 3 years, while receiving standardi...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2261-8

    authors: da Mota LM,Dos Santos Neto LL,Oliveira AC,Pereira IA,Burlingame RW,Ménard HA,Laurindo IM

    更新日期:2012-12-01 00:00:00

  • The effects of exercise on lipid profile in systemic lupus erythematosus and healthy individuals: a randomized trial.

    abstract::The aim of the present study was to evaluate the effects of an exercise training program on lipid profile and composition of high-density lipoprotein (HDL) subfractions in systemic lupus erythematosus (SLE) patients and healthy controls. A 12-week, randomized trial was conducted. Thirty-three physically inactive SLE p...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00296-014-3081-4

    authors: Benatti FB,Miossi R,Passareli M,Nakandakare ER,Perandini L,Lima FR,Roschel H,Borba E,Bonfá E,Gualano B,de Sá Pinto AL

    更新日期:2015-01-01 00:00:00

  • Tuberculous sacroiliitis: a case report.

    abstract::Tuberculosis can affect sacroiliac joints, but only a few such cases have been reported. The onset is usually insidious, and early diagnosis requires a high index of clinical suspicion. We report herein a culture-proven case of tuberculous sacroiliitis which initially mimicked neoplastic infiltration on CT scan. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-003-0406-0

    authors: Keleş I,Aydin G,Kitay OL,Orkun S

    更新日期:2004-09-01 00:00:00

  • Tribal and geographical variations of lupus in the Sultanate of Oman: a hospital-based study.

    abstract::Tribal differences are demonstrated in the presentation of lupus in Omani Gulf Arabs (OGA) and Omani Arabs of Persian descent (OAP), both groups resident in and indigenous to the Sultanate of Oman. The OAP have a lower risk of joint complications, skin rash, and dsDNA antibodies than OGA (beta coefficient and 95% conf...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-001-0151-1

    authors: Al Maini MH,El-Ageb el-N,Al-Shukaily AK,Al-Wahaibi S,Richens ER

    更新日期:2002-01-01 00:00:00

  • Rheumatoid arthritis masquerading as acromegaly recurrence: report of two cases.

    abstract::Acromegaly is a chronic endocrinopathy characterized by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-1 (IGF-1). The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. Rheumatoid arthritis (RA) is a rarely repo...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1490-6

    authors: Aydın Y,Coşkun H,Kır S,Yazici S,Kudaş Ö,Güngör A

    更新日期:2012-09-01 00:00:00

  • Backpack-related musculoskeletal symptoms among Nigerian secondary school students.

    abstract::Musculoskeletal discomfort in schoolchildren is significantly related to the weight and mode of carrying backpack to school. Prevalence and patterns of musculoskeletal discomfort among Nigerian secondary school students carrying backpack was investigated. Systematic sampling technique was used in the selection of the ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-014-2962-x

    authors: Hamzat TK,Abdulkareem TA,Akinyinka OO,Fatoye FA

    更新日期:2014-09-01 00:00:00

  • Serum serotonin levels and bone in rheumatoid arthritis patients.

    abstract::In rheumatoid arthritis (RA), a disease characterized by bone loss, increased levels of serotonin have been reported. Recent studies have demonstrated a role for circulating serotonin as a regulator of osteoblastogenesis, inhibiting bone formation. Thus, we measured serum serotonin levels (SSL) in a Portuguese sample ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-017-3836-9

    authors: Bernardes M,Vieira T,Lucas R,Pereira J,Costa L,Simões-Ventura F,Martins MJ

    更新日期:2017-11-01 00:00:00

  • Efficacy of EMLA cream phonophoresis comparison with ultrasound therapy on myofascial pain syndrome of the trapezius: a single-blind, randomized clinical study.

    abstract::The aim of this study is to investigate whether eutectic mixture of local anesthetics (EMLA) cream phonophoresis superior to conventional US over the trigger points (TPs) in terms of improvements of pain, range of motion and disability in myofascial pain syndrome (MPS). Fifty patients (42 female, 8 male) diagnosed wit...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00296-013-2881-2

    authors: Ustun N,Arslan F,Mansuroglu A,Inanoglu D,Yagız AE,Guler H,Turhanoglu AD

    更新日期:2014-04-01 00:00:00

  • Correlation of neurocognitive function and brain lesion load on magnetic resonance imaging in systemic lupus erythematosus.

    abstract::Neurocognitive dysfunction and brain injury on magnetic resonance imaging (MRI) are common in patients with systemic lupus erythematosus (SLE) and are associated with increased morbidity and mortality. However, brain MRI is expensive, is restricted by payers, and requires high expertise. Neurocognitive assessment is a...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-018-4080-7

    authors: Roldan PC,Jung RE,Sibbitt WL,Qualls CR,Flores RA,Roldan CA

    更新日期:2018-08-01 00:00:00

  • Production of platelet-derived growth factor in aseptic loosening of total hip replacement.

    abstract::Aseptic loosening is the predominant cause of total hip implant failure. It has been assumed that a layer or membrane, containing macrophages, fibroblasts and vascular endothelial cells, of synovial-like tissue develops at the implant-to-bone interface almost invariably and, with time, somehow leads to loosening of th...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s002960050037

    authors: Xu JW,Konttinen YT,Li TF,Waris V,Lassus J,Matucci-Cerinic M,Sorsa T,Santavirta TS

    更新日期:1998-01-01 00:00:00

  • Comparison of an administrative algorithm for SLE disease severity to clinical SLE Disease Activity Index scores.

    abstract::Systemic lupus erythematosus (SLE) severity, reflecting both disease intensity and duration, is heterogeneous making it challenging to study in administrative databases where severity may confound or mediate associations with outcomes. Garris et al. developed an administrative claims-based algorithm employing claims o...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-019-04477-4

    authors: Speyer CB,Li D,Guan H,Yoshida K,Stevens E,Jorge AM,Everett BM,Feldman CH,Costenbader KH

    更新日期:2020-02-01 00:00:00