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Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthritis.

Abstract：

:To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was measured. There was correlation between serum anti-CCP and DAS28-ESR. (R (2) = 0.71, P value < 0.01). New disease activity index was developed by replacing anti-CCP with ESR in DAS28-ESR. There was correlation between new model and DAS28-ESR. (R (2) = 0.91, P value < 0.01) The new composite index best cut-off values corresponding to DAS28-ESR values of 2.6, 3.2, and 5.1 were 3.21, 3.38, and 4.74, respectively. There was agreement between new model and DAS28-ESR for determination of patients in different disease activity categories. (Kappa = 0.71, P value < 0.01). The new disease activity index that applies serum anti-CCP may predict disease activity in RA.

journal_name

Rheumatol Int

journal_title

Rheumatology international

authors

Esalatmanesh K,Jamali R,Jamali A,Jamali B,Nikbakht M

doi

10.1007/s00296-011-2282-3

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

3799-805

issue

12

eissn

0172-8172

issn

1437-160X

journal_volume

32

pub_type

杂志文章

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