Abstract:
:The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease severity and are one measure of a disturbance in the degree of oxidation of the blood. Penicillamine, in common with other effective therapeutic agents, produces an increase in serum thiol concentration. It causes a greater effect on serum thiol reactivity than other drugs and in particular it increases 'fast reacting' thiol levels without significantly altering the 'slow reacting' thiol level.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Banford JC,Brown DH,Hazelton RA,McNeil CJ,Smith WE,Sturrock RDdoi
10.1007/BF00541162subject
Has Abstractpub_date
1982-01-01 00:00:00pages
107-11issue
3eissn
0172-8172issn
1437-160Xjournal_volume
2pub_type
杂志文章abstract::Here we evaluated whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have beneficial effects for collagen-induced arthritis (CIA). DBA/1 mice were immunized with bovine type-II collagen and administered 100 mg/kg of pravastatin interperitoneally. We measured the effects of pravastatin for CIA...
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1007/s00296-009-1142-x
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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更新日期:2012-05-01 00:00:00
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journal_title:Rheumatology international
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doi:10.1007/s00296-011-2282-3
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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doi:10.1007/s00296-009-1229-4
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00262708
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:Rheumatology international
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更新日期:2016-09-01 00:00:00
abstract::To describe the profile of Enthesitis Related Arthritis' (ERA) patients, in the era of biologic DMARDs (bDMARDs). This retrospective cohort study included patients with ERA monitored on a 3-month schedule for at least 1 year. Their metric assessment included the disease status and damage by applying the contemporary t...
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abstract::Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...
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pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint pain, inflammation, and loss of function. Disease pathogenesis involves activation and proliferation of autoreactive pro-inflammatory effector T cells. While the details of RA onset and progression remain controversial, dendritic cell (DC) nu...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3671-z
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Neprilysin (neutral endopeptidase, 3:4:24:11, CD10) (NEP) is a Zn metallopeptidase linked to controlling inflammation through the degradation of neuropeptides involved in neurogenic inflammation of chronic rheumatic diseases. The aim of our study was to evaluate circulating activity and cellular expression of...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0447-z
更新日期:2005-06-01 00:00:00