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An immunohistochemical study of immunological phenomena in minor salivary glands in patients with Sjögren's syndrome.

Abstract：

:Using different monoclonal antibodies, we performed an immunofluorescent technique on labial salivary glands in order to investigate the immunological phenomena involved in Sjögren's syndrome (SS). An aberrant expression of HLA-DR molecules was detected on cytoplasm of epithelial labial salivary cells in 9 out of 19 (47%) patients, with SS. No such expression was found in 8 patients without SS or in 3 normal controls. HLA-DQ molecules were demonstrated also in two out of ten SS patients without HLA-DR. A lymphocytic infiltration was not correlated with the expression of class II molecules. T cells bearing gamma delta receptors were not detected. The intracellular adhesion molecules (ICAM-1) and lymphocyte function associated antigen-1 (LFA-1) were not found on epithelial glandular salivary cells of patients and controls. In conclusion, these data suggested that the absence of ICAM-1 and LFA-1 in salivary cells and the absence of infiltrating T cells bearing gamma delta receptors exclude their immunopathogenetic role in SS; moreover, these data demonstrated that the aberrant expression of HLA class II molecules on epithelial salivary cells of patients with SS is not a phenomenon correlated with the lymphocytic infiltration.

journal_name

Rheumatol Int

journal_title

Rheumatology international

authors

Caretto A,Ostuni PA,Chieco-Bianchi F,Pedini B,Spadaccino AC,Bagnasco M,Todesco S,Betterle C

doi

10.1007/BF00262708

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

51-5

issue

2

eissn

0172-8172

issn

1437-160X

journal_volume

15

pub_type

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