Abstract:
:Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poor in lymphocytes and plasma cells, and perhaps in those areas of destroying pannus tissue that exhibited polymorphonuclear granulocytes (PMNs) at the pannus-cartilage junction. These results are in contrast to the idea that pannus tissue is a tumor-like lesion, for the present observations, even within the limits of autoradiographic investigations on a heterogeneous tissue, and indicate that pannus tissue has to be regarded as an inflammatory granulation tissue.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Mohr W,Hummler N,Pelster B,Wessinghage Ddoi
10.1007/BF00270349subject
Has Abstractpub_date
1986-01-01 00:00:00pages
127-32issue
3eissn
0172-8172issn
1437-160Xjournal_volume
6pub_type
杂志文章abstract::Isoform 4 of the human peptidylarginine deiminase (hPAD4) enzyme may be responsible for the citrullination of antigens in rheumatoid arthritis (RA) and has been shown to be itself the target of disease-specific autoantibodies. Here, we have tested whether the level of serum anti-hPAD4 antibodies in RA patients is stab...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1765-y
更新日期:2012-05-01 00:00:00
abstract::We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960000095
更新日期:2001-04-01 00:00:00
abstract::Acromegaly is a chronic endocrinopathy characterized by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-1 (IGF-1). The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. Rheumatoid arthritis (RA) is a rarely repo...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1490-6
更新日期:2012-09-01 00:00:00
abstract::The aim of this study was to investigate the percentage of regulatory T cells and the correlation with clinical activity in Behçet's disease. Forty Behçet's disease (BD) patients, 18 males and 22 females, were included in the study. The patients were diagnosed according to the published BD criteria. Twenty age- and se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2835-8
更新日期:2013-12-01 00:00:00
abstract::To assess the prognostic value of scleroderma pattern of nailfold capillary changes for the development of connective tissue diseases (CTD) in subjects with primary Raynaud's phenomenon (RP). The study included 3,029 consecutive patients with primary RP who had been followed at 6-month intervals during the mean of 4.8...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2109-2
更新日期:2012-10-01 00:00:00
abstract::Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. The presence of nailfold capillary abnormalities is useful in diagnosing SSc. Capillaroscopy, however, usually requires special equipment and may be time consuming. Dermatoscope has been presented as...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1532-0
更新日期:2011-12-01 00:00:00
abstract::Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are associated with an increased risk of coronary artery disease (CAD) as a result of accelerated atherosclerosis. However, the data on CAD risk of polymyalgia rheumatica (PMR), one of the most common chronic inflamm...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00296-016-3557-5
更新日期:2017-01-01 00:00:00
abstract::Systematic reviews and meta-analyses of randomized trials have long been important synthesis tools for guiding evidence-based medicine. More recently, network meta-analyses, an extension of traditional meta-analyses enabling the comparison of multiple interventions, use new statistical methods to incorporate clinical ...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-014-2994-2
更新日期:2014-11-01 00:00:00
abstract::Patients with rheumatoid arthritis (RA) are at increased risk of low bone density and fractures. This study identifies predictors of initiation of dual energy X-ray absorptiometry (DXA) testing in RA. We identified RA patients from the CORRONA registry with >or=1 year follow-up without reported DXA at study entry. The...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0804-4
更新日期:2009-06-01 00:00:00
abstract::Tumor necrosis factor (TNF) antagonists are among the most effective therapies for rheumatoid arthritis (RA), yet not all patients show a response. Using meta-analysis, this present study was designed to investigate whether or not the TNF-alpha promoter -308 A/G polymorphism is associated with responsiveness to anti-T...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s00296-006-0175-7
更新日期:2006-12-01 00:00:00
abstract::The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0461-z
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Neprilysin (neutral endopeptidase, 3:4:24:11, CD10) (NEP) is a Zn metallopeptidase linked to controlling inflammation through the degradation of neuropeptides involved in neurogenic inflammation of chronic rheumatic diseases. The aim of our study was to evaluate circulating activity and cellular expression of...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0447-z
更新日期:2005-06-01 00:00:00
abstract::Agalactosyl IgG [Gal(0)] was first discovered in patients with rheumatoid arthritis (RA). However, the proportion of this glycoform is also raised in tuberculosis and leprosy. This has helped reinforce the suggestion that RA may be triggered by a mycobacterium-like slow bacterial infection. On the other hand, arthriti...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00262090
更新日期:1995-01-01 00:00:00
abstract::The aims of this study were to assess the health-related quality of life (HRQoL) in patients with self-reported rheumatic diseases (RD), to classify self-reported rheumatic patients in groups according to their health state and to explore the associations between health status and sociodemographic variables. Data came...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3517-0
更新日期:2016-09-01 00:00:00
abstract::Tuberculosis can affect sacroiliac joints, but only a few such cases have been reported. The onset is usually insidious, and early diagnosis requires a high index of clinical suspicion. We report herein a culture-proven case of tuberculous sacroiliitis which initially mimicked neoplastic infiltration on CT scan. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0406-0
更新日期:2004-09-01 00:00:00
abstract::Tuberculosis (TB) is an important preventable infection in patients with rheumatoid arthritis (RA). To determine the risk of TB in patients with RA by comparing with those with non-specific back pain (NSBP), and to identify the risk factors in the RA group. Medical data were retrieved from a centralized electronic dat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04583-8
更新日期:2020-06-01 00:00:00
abstract::The aim of this study was to identify the possible determinants of impaired health-related quality of life (HRQOL) in Egyptian children and adolescents with juvenile idiopathic arthritis (JIA). Fifty-eight consecutive patients of JIA aged from 8 to 18 years underwent assessment of socio-economic and demographic charac...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-2950-1
更新日期:2014-08-01 00:00:00
abstract::Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1954-3
更新日期:2012-06-01 00:00:00
abstract::Abstract A 66-year-old woman showing renal dysfunction with elevated serum alkaline phosphatase and anti-SS-A antibody was admitted. A labial salivary gland biopsy showing infiltration of mononuclear cells and positive anti-SS-A antibody with sicca symptoms led to a diagnosis of primary Sjögren’s syndrome (SS). Fancon...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0924-5
更新日期:2009-12-01 00:00:00
abstract::We report our experience and hypothesis on the diagnosis and treatment of patients with vasculitis who are simultaneously diagnosed with serum-positive cytomegalovirus (CMV) immunoglobulin (Ig)M antibodies and negative CMV DNA polymerase chain reaction (PCR). It remains unknown how to treat this kind of "phantom" CMV ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0522-5
更新日期:2005-10-01 00:00:00
abstract::Establishing prevention and therapeutic strategies for osteoarthritis (OA) is necessary to minimize functional disability and the impact of the disease on society. The aim of this study was to determine the effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3148-2
更新日期:2015-03-01 00:00:00
abstract::The aim of the study was to test the frequency of CD4+ CD25(high)FoxP3 regulatory T cells in JIA patients and to assess their activation status and functional activity. The study involved 12 children with JIA and 35 healthy control subjects. PBMC were stained with monoclonal antibodies (anti-CD25, anti-CD4, anti-CD127...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1728-3
更新日期:2012-05-01 00:00:00
abstract::Gout results from multifactor interactions between gender, age, genetic and environmental factors. Environmental factors underlying gout and precipitating factors triggering acute attacks might vary in different populations with different lifestyles. In this study, we aimed to collect data regarding the demographic an...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-012-2442-0
更新日期:2013-04-01 00:00:00
abstract::Behçet disease (BD) is an inflammatory disorder of unknown origin. We present here an unusual case of juvenile Behçet with hemoptysis due to large pulmonary artery aneurysms (PAA), large intra-cardiac thrombus and prolonged fever, which posed several therapeutic challenges. In this case, a 14-year-old boy was admitted...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0730-5
更新日期:2009-03-01 00:00:00
abstract::The aim of this study was to analyze the longitudinal practice patterns of prophylaxis of glucocorticoid-induced osteoporosis in patients with polymyalgia rheumatica (PMR). Patients diagnosed with PMR were collected retrospectively in two rheumatology departments. In addition to demographic and diagnostic criteria, th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3014-2
更新日期:2014-10-01 00:00:00
abstract::To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2676-5
更新日期:2013-08-01 00:00:00
abstract::Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2340-x
更新日期:2013-01-01 00:00:00
abstract::Fibrosis is unregulated tissue repair that may cause impairment of organ function, especially in end-organ damage. Systemic sclerosis (SSc) is the prototype systemic fibrosing disorder. Classical targets for fibrosis in SSc like transforming growth factor Beta (TGF-β), Interleukin-6 (IL-6), and multiple tyrosine kinas...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04317-5
更新日期:2019-07-01 00:00:00
abstract::The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0210-2
更新日期:2002-07-01 00:00:00
abstract::Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side ef...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-020-04588-3
更新日期:2020-07-01 00:00:00