Abstract：
:Baseline and sequential liver biopsies were performed in ten patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) for more than 4 years. Liver biopsies were performed in all patients before the initiation of MTX therapy and were repeated after reaching a cumulative dose of 1500 mg or more. In four patients a third biopsy was performed 3 years after the first one. No significant worsening of hepatic architecture was found in any of our patients after 4 to 7 1/2 years of MTX therapy. No correlations between histologic findings and various clinical or pharmacological variables could be found. Our results suggested that prolonged MTX administration in RA patients did not cause severe hepatic abnormalities.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Tishler M,Caspi D,Halperin Z,Baratz M,Moshkowitz M,Yaron Mdoi
10.1007/BF00246875subject
Has Abstractpub_date
1992-01-01 00:00:00pages
39-41issue
1eissn
0172-8172issn
1437-160Xjournal_volume
12pub_type
临床试验,杂志文章abstract：:A simple technique for fine-needle aspiration biopsy from the synovial membrane of arthritis knee joints preceded by lavage of the joint cavity is described. The procedure was atraumatic, well accepted, and could be performed on outpatients. Cells originating from the synovial membrane were obtained in 12 of 17 knees ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00272430
更新日期：1988-01-01 00:00:00
abstract：:The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method comb...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270983
更新日期：1989-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) in Thai population is significantly associated with HLA-DR4 shared epitope (SE) alleles, particularly with DRB1*0405 (P = 0.00004, OR = 3.84, 95% CI = 1.93, 7.7). In addition, tumor necrosis factor-alpha (TNF-alpha) gene -863A alleles were found to be significantly increased in 77 RA patients...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0392-8
更新日期：2007-12-01 00:00:00
abstract：:A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270365
更新日期：1987-01-01 00:00:00
abstract：:We assess the usefulness of 99mTc-pertechnetate hand perfusion scintigraphy in patients with Raynaud's phenomenon (RP). The study population consisted of 18 patients with primary RP, 25 patients with secondary RP within systemic sclerosis (SSc), and ten healthy individuals. Gamma camera dynamic first-pass study during...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3584-2
更新日期：2016-12-01 00:00:00
abstract：:We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3618-9
更新日期：2017-01-01 00:00:00
abstract：:Using a sensitive and specific enzyme-linked immunosorbent assay (ELISA) assay we showed that the cryoglobulins of a patient with Lucio phenomenon contain phenolic glycolipid I antigen and a specific antibody. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541512
更新日期：1986-01-01 00:00:00
abstract：:The role of free radicals in fibromyalgia is controversial. In this study, 85 female patients with primary fibromyalgia and 80 age-, height-, and weight-matched healthy women were evaluated for oxidant/antioxidant balance. Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of free radical dam...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0427-8
更新日期：2005-04-01 00:00:00
abstract：UNLABELLED:The objective of this study is to provide a critical overview of available instruments to assess impairments in patients with rheumatic disorders, and to recommend reliable and valid instruments for use in allied health care and rehabilitation medicine. A computer-aided literature search (1982-2004) in sever...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-005-0603-0
更新日期：2005-09-01 00:00:00
abstract：:The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual X-ray absorptiometry), cumulative glucocorticoid dose, age, disease duration, body mass index (BMI) and parameters of dis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0576-x
更新日期：2008-09-01 00:00:00
abstract：:A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1670-4
更新日期：2011-05-01 00:00:00
abstract：:Regulatory T cells (Tregs) are supposed to stop immune responses in the course of immune activation. However, chronic activation of immune system in systemic lupus erythematosus (SLE) and many other autoreactive disorders are evidence of malfunction of this system. Therefore, it is plausible to quantify presence of th...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-010-1427-0
更新日期：2011-09-01 00:00:00
abstract：:Neuropathic arthropathy (NA), known as Charcot neuroarthropathy, is a chronic, degenerative arthropathy and is associated with decreased sensory innervation. Numerous causes of this arthropathy have been described. Neuropathic joint, although first described by Charcot in tabes dorsalis in 1868, has subsequently been ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1013-5
更新日期：2010-05-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is a systemic inflammatory disease in which a variety of thrombotic events may occur. However, to our knowledge, portal vein thrombosis (PVT), a potential cause of gastrointestinal bleeding, has not been described in the English literature. A previously well 47-year-old man diagnosed...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-0894-7
更新日期：2009-10-01 00:00:00
abstract：:Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04386-6
更新日期：2019-09-01 00:00:00
abstract：:A 45-year-old female presented to the rheumatology clinic with complaint of pain and swelling of multiple small joints of the hands and feet. She also complained of cough and shortness of breath onset around the same time. Since her cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor tests were posi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-1294-8
更新日期：2011-12-01 00:00:00
abstract：:A 7-year-old child was first admitted for persistent fever of 15-day duration and suspected meningitis. Kawasaki syndrome was lately diagnosed upon the recognition of an extensive diffuse coronary artery damage characterized by medium-sized aneurysms of the epicardial vessels. An eccentric thrombus along the inferior ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-1814-1
更新日期：2012-03-01 00:00:00
abstract：:This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050097
更新日期：1999-01-01 00:00:00
abstract：:Thrombocytosis is well described in children with Kawasaki disease (KD). We describe six children with KD who had thrombocytopenia at disease onset. This is an unusual finding and has clinical implications in the diagnosis of this condition. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0947-y
更新日期：2009-12-01 00:00:00
abstract：:Citrulline antibody, nowadays, is a new item which has been the center of attention due to its much more specificity to diagnose RA. The aim of the present study was to evaluate the efficacy and accuracy of anti-citrulline antibody test in RA diagnosis among hospitalized patients in Iran. Through a case-control study,...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2469-2
更新日期：2013-04-01 00:00:00
abstract：:A total of 95 patients suffering from active rheumatoid arthritis were included in this double-blind, placebo-controlled study of the immunomodulator OM-8980. Treatment was one capsule daily of OM-8980 or placebo for 6 months. A significant improvement was observed in the OM-8980 group in comparison with the placebo g...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00270248
更新日期：1989-01-01 00:00:00
abstract：:Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease. Of the numerous organ manifestations, involvement of the upper and lower gastrointestinal tract (GIT) appears to be the most frequent with regard to the clinical symptoms. However, as the frequency and clinical relevance of GI involvement in p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1988-6
更新日期：2012-08-01 00:00:00
abstract：:This study was designed to investigate the association of oral ulceration and oral health factors, together with psycho-social well-being in Behçet's disease (BD), and to clarify the importance of psycho-social support of patients in the overall management of BD. The study comprised of a cohort of 146 BD patients (mea...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4117-y
更新日期：2018-10-01 00:00:00
abstract：:As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibr...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-007-0403-9
更新日期：2007-09-01 00:00:00
abstract：:Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed c...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0357-5
更新日期：2004-07-01 00:00:00
abstract：:The aim of this study was to investigate the influence of various weather parameters on pain intensity levels in patients with acute low back pain (LBP). We performed a secondary analysis using data from the PACE trial that evaluated paracetamol (acetaminophen) in the treatment of acute LBP. Data on 1604 patients with...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3419-6
更新日期：2016-05-01 00:00:00
abstract：:Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis associated with BRAFV600E mutations in more than 50% of cases and presenting with 95% with skeletal lesions. However, cutaneous, pulmonary, large vessels and central nervous system involvement can also occur. We report a case of a 25-year-old wo...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04627-z
更新日期：2020-09-01 00:00:00
abstract：:A 47-year-old woman who had been treated for systemic lupus erythematosus (SLE) with myasthenia gravis (MG) was admitted to our hospital with acute onset of severe anemia after administration of isoniazid. Pure red cell aplasia (PRCA) was confirmed by elevated serum iron levels, reticulocytopenia and bone marrow aspir...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1113-2
更新日期：2010-11-01 00:00:00
abstract：:Monogenic autoinflammatory syndromes are a rare group of disorders characterized by periodic episodes of systemic inflammation of endogenous origin. Sometimes, these diseases may present with features akin to vasculitis. We conducted a literature review on such vasculitic manifestations in described monogenic autoinfl...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3839-6
更新日期：2018-01-01 00:00:00
abstract：:The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia. The aim of this study was to jointly address and integrate these se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1705-x
更新日期：2012-03-01 00:00:00
