Abstract:
:This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels were measured to establish plasma oxidant/antioxidant status in the patient and control groups. Patients with RA had lower AOP and NSSA but higher MDA levels than those of the control subjects, which was an indication of reduced antioxidant capacity and oxidant stress in these patients. Results suggest that the antioxidant system is impaired and peroxidation reactions are accelerated in patients with RA. We suppose that therapeutic use of some antioxidants may be beneficial in this regard.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Oztürk HS,Cimen MY,Cimen OB,Kaçmaz M,Durak Idoi
10.1007/s002960050097subject
Has Abstractpub_date
1999-01-01 00:00:00pages
35-7issue
1-2eissn
0172-8172issn
1437-160Xjournal_volume
19pub_type
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journal_title:Rheumatology international
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF00541164
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s002960050066
更新日期:1998-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 历史文章,杂志文章,评审
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-002-0246-3
更新日期:2002-11-01 00:00:00
abstract::Rheumatoid arthritis (RA) in Thai population is significantly associated with HLA-DR4 shared epitope (SE) alleles, particularly with DRB1*0405 (P = 0.00004, OR = 3.84, 95% CI = 1.93, 7.7). In addition, tumor necrosis factor-alpha (TNF-alpha) gene -863A alleles were found to be significantly increased in 77 RA patients...
journal_title:Rheumatology international
pub_type: 杂志文章
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