Abstract:
:In the present study, we have investigated comparatively the inflammatory response of patients with active and inactive osteoarthritis. The sera from 31 healthy individuals, 37 patients with active OA, and 19 patients with inactive OA were assayed for TNF-alpha, IL-6, sRANKL, RANTES, and MRP8 using ELISA in order to evaluate their potential as markers of disease activity. Also, the spontaneous and LSP-induced release of TNF-alpha and IL-6 by peripheral blood neutrophils was determined. The activation of OA is associated with elevated TNF-alpha, IL-6, and RANTES serum levels while sRANKL and MRP8 appeared to be increased in both active and inactive OA. The neutrophil spontaneous and up-regulated by LPS cytokine release can contribute to the exacerbation of OA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Toncheva A,Remichkova M,Ikonomova K,Dimitrova P,Ivanovska Ndoi
10.1007/s00296-009-0864-0subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1197-203issue
10eissn
0172-8172issn
1437-160Xjournal_volume
29pub_type
杂志文章abstract::Neurocognitive dysfunction and brain injury on magnetic resonance imaging (MRI) are common in patients with systemic lupus erythematosus (SLE) and are associated with increased morbidity and mortality. However, brain MRI is expensive, is restricted by payers, and requires high expertise. Neurocognitive assessment is a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4080-7
更新日期:2018-08-01 00:00:00
abstract::We have investigated the role of the Th17-related cytokines interleukin-17A (IL-17A), IL-21, and IL-23 in spondyloarthritis (SpA) by examining their association with disease activity and magnetic resonance imaging (MRI) findings in patients with SpA (n = 80). Furthermore, to investigate the cellular origins of the cyt...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1655-3
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abstract::The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1176-0
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abstract::The aim of this study was to identify the possible determinants of impaired health-related quality of life (HRQOL) in Egyptian children and adolescents with juvenile idiopathic arthritis (JIA). Fifty-eight consecutive patients of JIA aged from 8 to 18 years underwent assessment of socio-economic and demographic charac...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-2950-1
更新日期:2014-08-01 00:00:00
abstract::Although subclinical liver disease is common in systemic lupus erythematosus (SLE), strikingly high levels of liver enzymes are rare. Our aim was to determine the cause of high levels of liver enzymes in lupus patients, particularly in patients diagnosed with toxic hepatitis. We performed a retrospective chart review ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1237-4
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abstract::Establishing prevention and therapeutic strategies for osteoarthritis (OA) is necessary to minimize functional disability and the impact of the disease on society. The aim of this study was to determine the effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in...
journal_title:Rheumatology international
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更新日期:2015-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04285-w
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abstract::Methotrexate (MTX) can be toxic to patients suffering from end stage renal disease (ESRD) on hemodialysis even at low doses. This increase in toxicity is more notable in terms of bone marrow suppression in the form of pancytopenia. Many methods of elimination including dialysis itself have been proven ineffective, and...
journal_title:Rheumatology international
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abstract::Behçet's disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus formation (ICTF) is an uncommon but important complication of BD. To highlight recent insights into this disease, we aimed to review ICTF and other systemic involvements associated with ICTF in BD. We conducted a comprehensive review o...
journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0447-z
更新日期:2005-06-01 00:00:00
abstract::Takayasu arteritis (TA) is a chronic, inflammatory large vessel vasculitis that affects aorta and its main branches. We aimed to evaluate the incidence and prevalence of TA in the northwestern part of Turkey. We retrospectively evaluated 23 TA patients followed by our clinic. Clinical features, treatments and response...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/BF00290280
更新日期:1993-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1547-6
更新日期:2012-01-01 00:00:00
abstract::Articular involvement is a frequent extrahepatic manifestation of hepatitis C virus (HCV) infection. The distinction between HCV-related polyarthropathy and true RA may be very difficult, especially with recent onset RA before articular damage and erosions develop. The objective of the study is to assess the diagnosti...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1225-8
更新日期:2011-01-01 00:00:00
abstract::Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological parameters of acut...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00307733
更新日期:1993-01-01 00:00:00
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journal_title:Rheumatology international
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doi:10.1007/s00296-008-0565-0
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0440-6
更新日期:2004-11-01 00:00:00
abstract::Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether an...
journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
abstract::To study the combined effect of both genetic and environmental factors in the age of rheumatoid arthritis onset. Patients (n = 507). Shared epitope characterization was performed using Lifecodes HLA-SSO. Genotyping of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and signal transducers and activators...
journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274777
更新日期:1990-01-01 00:00:00
abstract::Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis associated with BRAFV600E mutations in more than 50% of cases and presenting with 95% with skeletal lesions. However, cutaneous, pulmonary, large vessels and central nervous system involvement can also occur. We report a case of a 25-year-old wo...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270454
更新日期:1988-01-01 00:00:00
abstract::Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04689-z
更新日期:2021-02-01 00:00:00
abstract::TNF-α is one of the key proinflammatory cytokines in pathogenesis of rheumatoid arthritis (RA). TNF-α was also found to enhance synthesis of leptin. Leptin is mainly adipocyte-derived hormone controlling appetite and energy expenditure. It acts through inhibition of neuropeptide Y secretion. It is possible that TNF-α-...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2182-6
更新日期:2012-11-01 00:00:00