Inflammatory response in patients with active and inactive osteoarthritis.

Abstract:

:In the present study, we have investigated comparatively the inflammatory response of patients with active and inactive osteoarthritis. The sera from 31 healthy individuals, 37 patients with active OA, and 19 patients with inactive OA were assayed for TNF-alpha, IL-6, sRANKL, RANTES, and MRP8 using ELISA in order to evaluate their potential as markers of disease activity. Also, the spontaneous and LSP-induced release of TNF-alpha and IL-6 by peripheral blood neutrophils was determined. The activation of OA is associated with elevated TNF-alpha, IL-6, and RANTES serum levels while sRANKL and MRP8 appeared to be increased in both active and inactive OA. The neutrophil spontaneous and up-regulated by LPS cytokine release can contribute to the exacerbation of OA.

journal_name

Rheumatol Int

authors

Toncheva A,Remichkova M,Ikonomova K,Dimitrova P,Ivanovska N

doi

10.1007/s00296-009-0864-0

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

1197-203

issue

10

eissn

0172-8172

issn

1437-160X

journal_volume

29

pub_type

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