Abstract:
:Chlamydia trachomatis (Ct)-induced arthritis (CtIA) is characterized by persistent Ct infection, which stimulates secretion of cytokines in vitro. We therefore investigated whether CtIA patients have a unique cytokine profile in synovial fluid or serum in vivo. Because underlying Ct infection is overlooked in a high percentage of patients with initially diagnosed undifferentiated oligoarthritis (UOA), we examined whether determination of cytokines might also be of diagnostic relevance for this arthritis form. Matched serum and synovial fluid specimens from 26 patients with CtIA were analyzed and compared to those from 34 patients with UOA in whom Ct infection was excluded and those of nine patients with rheumatoid arthritis (RA). In 15 CtIA patients, Ct DNA from synovial fluid could be amplified by polymerase chain reaction. The following cytokine or cytokine antagonists were measured by enzyme-linked immunosorbent assay: interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, IL-6, IL-1 receptor antagonist, and soluble TNF receptor p75. No statistically significant differences in cytokine levels between patients with CtIA or the other arthritis forms were detected. Also, comparison between CtIA patients with (n = 17) and without Chlamydia DNA (n = 9) in synovial fluid revealed no significant differences for these cytokines. Cytokine levels in serum and synovial fluid were not different between CtIA, UOA without Ct infection, and RA patients. The intracellular presence of Ct was not associated with a specific profile of these cytokines in vivo.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Jendro MC,Raum E,Schnarr S,Köhler L,Zeidler H,Kuipers JG,Martin Mdoi
10.1007/s00296-003-0393-1subject
Has Abstractpub_date
2005-01-01 00:00:00pages
37-41issue
1eissn
0172-8172issn
1437-160Xjournal_volume
25pub_type
杂志文章abstract::Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have poor prognosis, and pulmonary endarterectomy (PEA) is considered the treatment of choice for this condition. We report a case and review the literature of successful PEA for CTEPH due to antiphospholipid syndrome associated with systemic lupus er...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-011-2346-4
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journal_title:Rheumatology international
pub_type: 杂志文章
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abstract::Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were fi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541284
更新日期:1986-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541162
更新日期:1982-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541593
更新日期:1983-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541164
更新日期:1982-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3197-6
更新日期:2015-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0255-2
更新日期:2003-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541361
更新日期:1984-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1142-x
更新日期:2010-11-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541245
更新日期:1982-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04411-8
更新日期:2019-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0440-6
更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00296-009-1252-5
更新日期:2011-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1129-7
更新日期:2010-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00290330
更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章,实务指引,评审
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更新日期:2012-05-01 00:00:00
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s002960050079
更新日期:1999-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0357-5
更新日期:2004-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541512
更新日期:1986-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00296-008-0523-x
更新日期:2008-06-01 00:00:00