Abstract:
:The aim was to further characterize the SKG model of rheumatoid arthritis (RA) and its potential for studying intervention treatments, with special focus on bone targeting therapies. Three individual studies were conducted, using a total of 71 SKG mice, comparing arthritis induction with mannan versus zymosan A, female versus male mice, and the effect of dexamethasone intervention treatment initiated at different time points after arthritis induction. Hind paws were embedded undecalcified in methyl methacrylate, and sections were stained with Masson-Goldner trichrome. Areal Bone Mineral Density (aBMD) of the femora was determined with pDXA. RNA was extracted from the hind paws followed by the quantification by reverse transcriptase PCR. SKG mice stimulated with mannan presented a higher arthritis score than mice stimulated with zymosan A. Female SKG mice developed a more severe arthritis than male SKG mice. Dexamethasone inhibited arthritis clinically as well as histologically when the treatment was initiated prophylactically or within the first week of arthritis. Femoral aBMD was lower in animals with arthritis than in control animals. The RANKL RNA expression was elevated in arthritic mice, whereas OPG RNA expression was unchanged. The results suggest mannan as arthritis inductor and female instead of male mice in experiments as well as an optimal time window for the initiation of treatment. Systemic bone loss as well as local up regulation of RANKL was present early in SKG arthritis. These results demonstrate that SKG arthritis is a suitable new model for evaluating therapies in RA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Keller KK,Lindgaard LM,Wogensen L,Dagnæs-Hansen F,Thomsen JS,Sakaguchi S,Stengaard-Pedersen K,Hauge EMdoi
10.1007/s00296-012-2500-7subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1127-33issue
5eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract::To investigate the efficacy of etanercept and MTX (methotrexate) combination therapy in Chinese patients with ankylosing spondylitis hip joint lesion, the possible courses and maintenance protocol, altogether 97 ankylosing spondylitis patients fulfilling the modified New York criteria with hip joint lesion were enroll...
journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,评审
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Rheumatology international
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pub_type: 评论,信件
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journal_title:Rheumatology international
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更新日期:2006-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541220
更新日期:1981-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,评审
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