Abstract：
:This study was performed to investigate the frequency of human leukocyte antigen (HLA)-B27 in Chinese patients with suspected of ankylosing spondylitis (AS) and to assess the clinical significance of HLA-B27 typing. A total of 1,016 patients suspected of AS were classified into six groups based on one major AS-related clinical manifestation. HLA-B27 was determined by polymerase chain reaction using sequence-specific primers. The frequency of B27 ranged between 24.3 and 46.7% among the patient groups, significantly higher than in healthy controls (2.4%). In the same group, the frequency of B27 in young (< or = 40 years) and in male patients was significantly higher than in the old and in female (P < 0.01). During a 1-year follow-up, 102 subjects were definitely diagnosed as AS, but only one B27(-) patient. Of the 102 definite patients, 69 (67.6%) definite patients were distributed in group 1 (low back pain and stiffness) with the higher incidence (28.5%) of AS. The incidence of AS in the same group was found with a similar pattern to the frequency of B27, in male and young patients significantly greater, except groups 4 and 6 (peripheral arthritis and alteration of skin). These findings confirm that HLA-B27 is one of sensitive diagnostic tools for early AS and suggest that there was a remarkable clinical significance of HLA-B27 typing in Chinese patients suspected of AS, particularly a young man who presents with low back pain and stiffness for > 3 months.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Liu X,Li YR,Hu LH,Zhou ZM,Chen FH,Ning Y,Yao QFdoi
10.1007/s00296-009-1148-4subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1305-9issue
10eissn
0172-8172issn
1437-160Xjournal_volume
30pub_type
杂志文章abstract：:The aim of the study is to investigate the levels of serum interleukin-35 (IL-35) before and after treatment and its relationship with clinical parameters as well as the frequency of different subsets of CD4+ T cells in patients with systemic sclerosis (SSc) to explore the role of IL-35 in the pathogenesis of SSc. The...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4071-8
更新日期：2018-08-01 00:00:00
abstract：:There is still debate on whether inflammatory pseudotumor should be considered benign or malignant. This lesion has only been reported twice in bone, apart from cases complicating foreign body reaction to joint replacement arthroplasty. We report here a third case, localized at the sacrum. A 31-year-old man had inflam...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0365-5
更新日期：2004-05-01 00:00:00
abstract：:The mechanisms of male idiopathic osteoporosis are little known. We evaluated bone mineral loss by dual-energy X-ray absorptiometry and determined its cortical or trabecular nature in a cohort of men with idiopathic osteoporosis with fractures. Thirty-nine men (mean age 60 ± 13 years), with negative investigations for...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2076-7
更新日期：2012-10-01 00:00:00
abstract：:Synovial fluids of patients suffering from rheumatoid arthritis contain elevated levels of granulocyte (PMN) elastase in complex with alpha 1-proteinase inhibitor (alpha 1-PI), whereas free-elastase activity is usually not detectable. This absence of free enzymatic activity in joint effusions has cast some doubt on th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270466
更新日期：1987-01-01 00:00:00
abstract：:A 47-year-old woman who had been treated for systemic lupus erythematosus (SLE) with myasthenia gravis (MG) was admitted to our hospital with acute onset of severe anemia after administration of isoniazid. Pure red cell aplasia (PRCA) was confirmed by elevated serum iron levels, reticulocytopenia and bone marrow aspir...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1113-2
更新日期：2010-11-01 00:00:00
abstract：:The aim of this study was to evaluate the total antioxidant status (TAS), total oxidative status (TOS) and oxidative stress index (OSI) in patients with postmenopausal osteoporosis. We also investigate the relation between bone mineral density and oxidative/antioxidative parameters. Thirty-nine patients with osteoporo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0452-0
更新日期：2008-02-01 00:00:00
abstract：:Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial flu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0006-2
更新日期：2006-03-01 00:00:00
abstract：:Thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP) is a rare but potentially lethal condition requiring rapid recognition, diagnosis, and initiation of therapy. We experienced a case of a 61-year-old woman with primary Sjögren's syndrome (pSS) complicated with severe renal TMA/TTP following IgM...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1569-0
更新日期：2013-01-01 00:00:00
abstract：:Activated T lymphocytes (Ia+ T-cells) in peripheral blood are associated with immune stimulation. We found the percentages of these cells significantly increased in 95% of rheumatoid arthritis (RA) patients. Our studies showed no relation between the percentages of these cells in peripheral blood and concurrent erythr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00272435
更新日期：1988-01-01 00:00:00
abstract：:Activation of opioid receptors on peripheral sensory nerve terminals by opioid peptides that are produced and released from immune cells can result in inhibition of inflammatory pain. This study tests the hypothesis that postoperative pain is attenuated endogenously through a local sympathetic neurotransmitter-activat...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-010-1489-z
更新日期：2011-10-01 00:00:00
abstract：:We assess the usefulness of 99mTc-pertechnetate hand perfusion scintigraphy in patients with Raynaud's phenomenon (RP). The study population consisted of 18 patients with primary RP, 25 patients with secondary RP within systemic sclerosis (SSc), and ten healthy individuals. Gamma camera dynamic first-pass study during...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3584-2
更新日期：2016-12-01 00:00:00
abstract：:Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 pat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2821-1
更新日期：2013-11-01 00:00:00
abstract：:Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children and adolescents who had undergone serum uric acid (SUA) measurement at the Chang Gung Memorial Hospital betwe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2808-y
更新日期：2013-11-01 00:00:00
abstract：:Ultrasound (US)-guided corticosteroid injection has been shown to be safe and effective for varied causes of plantar fasciitis; however, its use for Achilles tendinitis is controversial. We studied the efficacy and changes in US findings at Achilles enthesitis after corticosteroid injection in patients with spondyloar...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3440-4
更新日期：2016-06-01 00:00:00
abstract：:Objective of the study is to compare the diagnostic accuracy for detecting monosodium urate crystal deposits between dual-energy CT (DECT) and ultrasound (US). Sixty consecutive patients (49 men, mean age 62 years) with clinically suspected gout were included in this case-control study. DECT and US of feet, knees, han...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-2979-1
更新日期：2014-06-01 00:00:00
abstract：:The authors report an unusual case of myelodysplastic syndrome (MDS) associated with ankylosing spondylitis (AS). A 40-year-old-man with MDS presented with chronic low back pain for 6 years. Four years ago, MDS was diagnosed during routine blood analysis for the work-up of his articular complaints. His initial articul...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0735-0
更新日期：2009-04-01 00:00:00
abstract：:An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3774-6
更新日期：2017-10-01 00:00:00
abstract：:There is no agreement among the rheumatology community in how to implement the musculoskeletal ultrasound (MSUS) technique in the Rheumatology Divisions. To test the perceived usefulness of the MSUS, under consensus indications, for referring colleagues for the clinical management of their patients with inflammatory a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3538-8
更新日期：2016-12-01 00:00:00
abstract：:Anemia is common with connective tissue disorders, but pancytopenia is rare. We report a 22-year-old female who presented with menorrhagia, seizures, anemia, leukocytosis, thrombocytopenia, pericardial effusion, positive ANA, and evidence of vasculitis on CT head scan and was diagnosed with systemic lupus erythematosu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0318-z
更新日期：2004-01-01 00:00:00
abstract：:We aimed to investigate the diagnostic significance of high frequency ultrasonography (USG), comparing the findings in USG, bone scintigraphy and clinical stuation. Fifty-one patients who had early symptoms of inflammatory arthritis, but not fulfilling the ACR diagnostic criteria for rheumatoid arthritis (RA) were inc...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0765-7
更新日期：2009-05-01 00:00:00
abstract：:Articular involvement is a frequent extrahepatic manifestation of hepatitis C virus (HCV) infection. The distinction between HCV-related polyarthropathy and true RA may be very difficult, especially with recent onset RA before articular damage and erosions develop. The objective of the study is to assess the diagnosti...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1225-8
更新日期：2011-01-01 00:00:00
abstract：:Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,评审
doi：10.1007/BF02274749
更新日期：1990-01-01 00:00:00
abstract：:We characterized the anemia in monkey collagen-induced arthritis (CIA) to evaluate whether this model is useful to analyze the basis of an anemia of inflammatory diseases. Cynomolgus monkey was immunized with bovine type II collagen on days 0 and 21. Blood samples were collected regularly and hematological parameters,...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0547-2
更新日期：2008-07-01 00:00:00
abstract：:CCL28 is a mucosa-associated epithelial-cell-produced chemokine involved in oral defense. We assessed the level of CCL28 in saliva of primary Sjögren's syndrome (pSS) patients in comparison with healthy controls and correlated it with IgA salivary levels. We included 30 non-smoker pSS patients and 30 non-smoker health...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3210-0
更新日期：2015-08-01 00:00:00
abstract：:We report a case of visceral leishmaniasis in a patient from northern Norway with psoriatic arthritis treated with a combination of etanercept and methotrexate. The patient resided extensively in southern Spain, a zone endemic for leishmania. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2483-4
更新日期：2013-10-01 00:00:00
abstract：:Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1374-9
更新日期：2011-06-01 00:00:00
abstract：:Addison's disease is an autoimmune process. However, Addison's disease associated with connective tissue diseases (CTD) is only occasionally reported. Here, we report six cases of Addison's disease secondary to a variety of CTD, which include systemic lupus erythematosus, Takayasu arteritis, systemic sclerosis, ankylo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0749-7
更新日期：2009-04-01 00:00:00
abstract：:Arachnoid ossificans is a rare type of chronic arachnoiditis characterised by the presence of calcification or ossification of the dura and arachnoid. There are a few reports of these findings in relation to various disease entities, but only one case has been reported in relation to ankylosing spondylitis. We describ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2293-0
更新日期：2013-06-01 00:00:00
abstract：:Hydroxyapatite crystals are often deposited in the vicinity of joints, where they can cause a clinical periarthritis. Clodronate is a first-generation bisphosphonate that has the ability to reduce ectopic calcifications. Two women were affected by disabling calcific periarthritis of the shoulders lasting for years and...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1575-2
更新日期：2011-03-01 00:00:00
abstract：:This study was designed to determine the effects of the osteoprotegerin (OPG) on the mRNA expression of carbonic anhydrase II (CAII) and the receptor activator of NF-κB (RANK) in mouse osteoclast-like cells. Marrow cells were harvested from femora and tibiae of mouse and cultured in 6-well chamber slides. After 1 day ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2338-4
更新日期：2012-12-01 00:00:00
