Abstract：
:Thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP) is a rare but potentially lethal condition requiring rapid recognition, diagnosis, and initiation of therapy. We experienced a case of a 61-year-old woman with primary Sjögren's syndrome (pSS) complicated with severe renal TMA/TTP following IgM monoclonal gammopathy of undetermined significance (MGUS). She was admitted to our hospital for further evaluation of hypergammaglobulinema, acute renal failure, and severe thrombocytopenia. She had been diagnosed with pSS 13 years prior to admission. Histological examination of her kidney revealed fibrin thrombi in the glomeruli and arterioles, a finding that is consistent with TMA/TTP. The patient was subsequently treated with plasma exchange, which resulted in a successful outcome without any complications. This rare case suggests that it is important to make a therapeutic decision based on appropriate and prompt pathological diagnosis.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Koga T,Yamasaki S,Nakamura H,Kawakami A,Furusu A,Taguchi T,Eguchi Kdoi
10.1007/s00296-010-1569-0subject
Has Abstractpub_date
2013-01-01 00:00:00pages
227-30issue
1eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract：:In spite of differences in etiology, RA and OA lead to astonishingly similar synovitic alterations. Fibroblastic transformation of the synovial membrane and an increase in monocytes constitute a rare but highly characteristic feature of RA. Monocytes synthesize factor (F) XIII, implying that FXIII (a and s) in synovia...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF01419952
更新日期：1996-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disorder leading to disability and reduced quality of life. Effective treatment with biologic DMARDs poses a significant economic burden. The Abatacept versus Adalimumab Comparison in Biologic-Naïve RA Subjects with Background Methotrexate (AMPLE) trial was a head-to...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00296-017-3739-9
更新日期：2017-07-01 00:00:00
abstract：:In recent years, scientific efforts on the topic "gout" have focused on pathogenetic aspects. This has opened new strategies of anti-inflammatory therapy and has improved urate-lowering therapy. So far, a scientometric analysis of the topic "gout" has not been generated despite an increased need for it in times of mod...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2805-1
更新日期：2013-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1670-4
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-011-2078-5
更新日期：2012-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/pl00006846
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1573-4
更新日期：2012-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0107-6
更新日期：2006-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274821
更新日期：1990-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4010-8
更新日期：2018-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-2962-x
更新日期：2014-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3148-2
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journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-016-3441-3
更新日期：2016-05-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0208-9
更新日期：2002-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3677-6
更新日期：2017-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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journal_title：Rheumatology international
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541512
更新日期：1986-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3568-2
更新日期：2016-12-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is a systemic inflammatory disease in which a variety of thrombotic events may occur. However, to our knowledge, portal vein thrombosis (PVT), a potential cause of gastrointestinal bleeding, has not been described in the English literature. A previously well 47-year-old man diagnosed...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-0894-7
更新日期：2009-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541337
更新日期：1985-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002960050113
更新日期：2000-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1519-x
更新日期：2011-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2182-6
更新日期：2012-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541597
更新日期：1983-01-01 00:00:00
abstract：:This study examines whether or not MBD4 polymorphism is a marker for rheumatoid arthritis (RA) susceptibility or severity for Chinese patients in Taiwan. This study included 193 patients with RA, while 190 unrelated healthy individuals living in Central Taiwan served as controls. The relationship between MBD4 polymorp...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1545-8
更新日期：2012-01-01 00:00:00
