Fibromyalgia is associated to receiving chronic medications beyond appropriateness: a cross-sectional study.


:The objectives of this study are to describe appropriateness and drug treatment of comorbidities in fibromyalgia (FM). Cross-sectional study of a group of patients. Number of drugs, indication, duration and appropriateness of prescriptions were evaluated. Patients were classified as: group 1, (FM/FM) previous FM diagnosis and fulfilling criteria; group 2, (noFM/noFM) other diagnosis and not fulfilling criteria; and group 3, (noFM/FM) other diagnosis but fulfilling criteria. Drugs were classified into drugs for nervous system, analgesics/NSAID and drugs for other comorbidities. Appropriateness was evaluated following clinical therapeutic guidelines. A total of 159 patients were included in the study and classified into group 1, with 59 patients; group 2, with 67 patients; and group 3, with 33 patients. Group 1 received a greater number of different drugs and for a longer period of time, there were less severe comorbidities and more unjustified treatments. No difference was found between the other two groups. Major opioids were only consumed in group 1. Also, in group 1, 45.8 % of patients were attended in psychiatry versus 15.6 % in group 3 and 3 % in group 2. The number of somatic symptoms correlated significantly with the number of drugs. Nervous system treatments were of shorter duration than other drug treatments. There was no difference in severe comorbidities. Comorbidities in FM are similar to those of other patients, but they receive more drugs and for a longer period of time. Drugs for nervous system comorbidities are introduced later, when other somatic symptoms are already treated. In patients with FM the treatments for mild comorbidities are not well justified.


Rheumatol Int


Rivera J,Vallejo MA




Has Abstract


2016-12-01 00:00:00














  • Enzyme-linked immunosorbent assays for antibodies to poly(A), poly dAT and histones: possibly useful tools for the evaluation of prognosis and disease activity in systemic lupus erythematosus.

    abstract::In a prospective study 222 sera from 56 patients with systemic lupus erythematosus (SLE) were tested for antibodies to poly(A), poly dAT and histones using enzyme-linked immunosorbent assay (ELISA). Patients with active disease had significantly more often antibodies to poly(A), poly dAT and histones than patients wit...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Helve T,Gripenberg M,Kurki P,Teppo AM,Wegelius O

    更新日期:1984-01-01 00:00:00

  • Individuals with fibromyalgia and depression: findings from a nationally representative Canadian survey.

    abstract::The aim of the study is to determine the prevalence of and factors associated with major depression among those with Fibromyalgia Syndrome (FMS) in a Canadian representative sample. The study was a secondary analysis of a large, nationally representative sample from the Canadian Community Health Survey. The full sampl...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Fuller-Thomson E,Nimigon-Young J,Brennenstuhl S

    更新日期:2012-04-01 00:00:00

  • A comparison of performance of anti-cyclic citrullinated peptide 2 and citrullinated protein antibodies in the diagnosis of rheumatoid arthritis in Iranian patients.

    abstract::Antibodies to citrullinated proteins and rheumatoid factor (RF) are widely used in patients with rheumatoid arthritis (RA) and the antibodies to citrullinated proteins appear to be the most specific markers of the disease. The objective was to compare the diagnostic performance of the anti-cyclic citrullinated peptide...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Aflaky E,Shenavandeh S,Ashraf MJ

    更新日期:2010-02-01 00:00:00

  • Coronavirus disease 2019 (COVID-19) in a patient with ankylosing spondylitis treated with secukinumab: a case-based review.

    abstract::Severe acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potenti...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Coskun Benlidayi I,Kurtaran B,Tirasci E,Guzel R

    更新日期:2020-10-01 00:00:00

  • Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy.

    abstract::Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (tota...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Choi BR,Ahn MJ,Lee WS,Kim TH,Bae SC,Jun JB

    更新日期:2005-05-01 00:00:00

  • Involvement of soluble receptor activator of nuclear factor-κB ligand (sRANKL) in collagenase-induced murine osteoarthritis and human osteoarthritis.

    abstract::Joint destruction and excessive bone formation are associated with high expression of soluble receptor activator of nuclear factor-κB ligand (sRANKL). This study was undertaken to investigate the role of sRANKL in collagenase-induced osteoarthritis (CIOA) in mice and in patients with osteoarthritis (OA). The initial p...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Dimitrova P,Toncheva A,Gyurkovska V,Ivanovska N

    更新日期:2012-05-01 00:00:00

  • Crystalglobulinemia manifested as acute renal failure and thrombotic vasculopathy.

    abstract::Crystalglobulinemia is an extremely rare pathology that is associated in most cases with plasma cell dyscrasia, mainly multiple myeloma. In most cases, it may be the manifestation of incipient gammopathy or it manifests shortly after diagnosis. We report a patient with ischemic lesions of thrombotic origin in lower li...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Gómez-Lechón Quirós L,Acosta De La Vega ME,Compán Fernández O,Pastor Navarro S,Montilla Morales C,Moyano Bueno D,Martín Centellas J,Santos-Briz Terrón A,Hidalgo Calleja C

    更新日期:2020-08-01 00:00:00

  • Heart rate variability in patients with rheumatoid arthritis.

    abstract::Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Evrengül H,Dursunoglu D,Cobankara V,Polat B,Seleci D,Kabukçu S,Kaftan A,Semiz E,Kilic M

    更新日期:2004-07-01 00:00:00

  • Quantitative studies of the interaction of 3H-dsDNA/anti-DNA immune complexes with complement: comparison and evaluation of the Raji cell, the solution phase C1Q, and the red blood cell linked complement fixation radioimmunoassays.

    abstract::We have prepared antibody/3H-dsDNA immune complexes and have used three independent radioimmunoassays to quantitate their interaction with complement; the solution phase C1q assay, the Raji cell assay, and a complement-based red blood cell adherence assay (RBC-CF). Our results indicate that although there is reasonabl...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Taylor RP,Andrews BS,Morley KW,Conlon T

    更新日期:1981-01-01 00:00:00

  • Deforming arthropathy in SLE: review in the literature apropos of one case.

    abstract::Among the clinical manifestations of systemic lupus erythematosus is an arthropathy, which is usually non-erosive. In many cases, the joint involvement is mild. A subset of patients has deforming, non-erosive Jaccoud's arthropathy, and a minority have an arthropathy with clinical findings similar to rheumatoid arthrit...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Pipili C,Sfritzeri A,Cholongitas E

    更新日期:2009-08-01 00:00:00

  • Felty syndrome: autoimmune neutropenia or immune-complex-mediated disease?

    abstract::Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Breedveld FC,Lafeber GJ,Doekes G,Claas FH,Cats A

    更新日期:1985-01-01 00:00:00

  • Surgical synovectomy combined with yttrium 90 in patients with recurrent joint synovitis.

    abstract::Radiation synovectomy (RS) is one of many therapeutic options used for recurrent joint synovitis. Our aim was to analyze the effect of the surgical synovectomy combined with yttrium 90 ((90)Y) in the treatment for recurrent joint synovitis. A surgical combined RS procedure was used on 32 knees of 30 patients. They wer...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Oztemür Z,Bulut O,Korkmaz M,Gölge UH,Oztürk H,Tezeren G,Günaydın I

    更新日期:2013-05-01 00:00:00

  • Iloprost infusion does not reduce oxidative stress in systemic sclerosis.

    abstract::Systemic sclerosis is a connective tissue disease in which oxidative stress represents an important player among the complex pathogenetic mechanisms of the disease. Iloprost, an analogue of natural prostacyclin, is used in systemic sclerosis for the treatment of severe Raynaud's phenomenon and ischemic ulcers. There i...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章


    authors: Volpe A,Biasi D,Caramaschi P,Bambara LM,Carletto A,Degan M,Minuz P

    更新日期:2008-02-01 00:00:00

  • Is Still's disease still one disease? A case of Adult-onset Still's disease showing accumulation in the carotids and the large vessels of the legs on positron emission tomography: CT images.

    abstract::Adult-onset Still's disease (AOSD) is known as a systemic inflammatory disease of unknown etiology and pathogenesis, characterized by fever, skin eruptions, systemic organ involvement, and arthralgias. AOSD is difficult to diagnose because of its heterogeneous clinical manifestations and prevalence (although more prev...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: de Graaff LC,ten Broek MR,Schweitzer DH

    更新日期:2012-08-01 00:00:00

  • Reduction in jaw opening: a neglected symptom of giant cell arteritis.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kraemer M,Metz A,Herold M,Venker C,Berlit P

    更新日期:2011-11-01 00:00:00

  • OPG inhibits gene expression of RANK and CAII in mouse osteoclast-like cell.

    abstract::This study was designed to determine the effects of the osteoprotegerin (OPG) on the mRNA expression of carbonic anhydrase II (CAII) and the receptor activator of NF-κB (RANK) in mouse osteoclast-like cells. Marrow cells were harvested from femora and tibiae of mouse and cultured in 6-well chamber slides. After 1 day ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Chen J,He JQ,Zhen SY,Huang LQ

    更新日期:2012-12-01 00:00:00

  • The demographic and clinical spectrum of Arab versus Asian patients with ankylosing spondylitis in the UAE.

    abstract::Ankylosing spondylitis is a rather uncommon condition in the UAE. Over a period of 10 years. 28 hospital-based patients diagnosed as having AS were retrospectively studied. They included 17 Arabs and 11 Asians. The onset of AS in most patients in this study was in adulthood (mean age at onset was 27.7 years in Arabs a...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: al Attia HM,Sherif AM,Hossain MM,Ahmed YH

    更新日期:1998-01-01 00:00:00

  • Arthritic presentation of childhood malignancy: beware of normal blood counts.

    abstract::Some children with malignancy (e.g. acute lymphoblastic leukemia) who initially present with musculoskeletal complaints may be misdiagnosed as having a rheumatological disorder. In the literature, importance has been given to subtle changes in blood counts, which may point toward an underlying malignancy. We report 3 ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Suri D,Ahluwalia J,Sachdeva MU,Das R,Varma N,Singh S

    更新日期:2011-06-01 00:00:00

  • Antibodies to Sm and SS-A demonstrated by enzyme immunoassay. Correlation to clinical manifestations and disease activity in patients with systemic lupus erythematosus.

    abstract::Using commercially available antigens, enzyme-linked immunosorbent assays (ELISAs) were set up to demonstrate antibodies of IgG class against Sm and SS-A. Anti-Sm antibodies were demonstrated in 40% of patients with systemic lupus erythematosus (SLE), in 12% of patients with SJögren's syndrome, in 6% of patients with ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Gripenberg M,Teppo AM,Friman C

    更新日期:1991-01-01 00:00:00

  • Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.

    abstract::The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1alpha and tumor necrosis factor (TNF) alpha, and the concentration...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Chang DM,Liu SH,Lee HS,Lai JH,Chen CH

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  • Pro-brain natriuretic peptide (ProBNP) levels in North Indian children with Kawasaki disease.

    abstract::The diagnosis of Kawasaki disease (KD), a common pediatric vasculitis, is based solely on clinical criteria. There is a need for a robust laboratory marker that can help differentiate KD from other acute, febrile, childhood illnesses and also to predict cardiac involvement. We conducted a cross-sectional study of 25 c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Reddy M,Singh S,Rawat A,Sharma A,Suri D,Rohit MK

    更新日期:2016-04-01 00:00:00

  • Propylthiouracil-induced autoimmune syndromes: 11 case report.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Wu R,Li R

    更新日期:2012-03-01 00:00:00

  • Phantom cytomegalovirus infection in vasculitis patients: what it means and what to do.

    abstract::We report our experience and hypothesis on the diagnosis and treatment of patients with vasculitis who are simultaneously diagnosed with serum-positive cytomegalovirus (CMV) immunoglobulin (Ig)M antibodies and negative CMV DNA polymerase chain reaction (PCR). It remains unknown how to treat this kind of "phantom" CMV ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Katsanos KH,Kostoula A,Katopodis KP,Siamopoulos KC

    更新日期:2005-10-01 00:00:00

  • Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Rodríguez-Rodríguez L,Lamas JR,Varadé J,Tornero-Esteban P,Abasolo L,de la Concha EG,Jover JA,Urcelay E,Fernández-Gutiérrez B

    更新日期:2012-10-01 00:00:00

  • Cardiovascular risk in patients with rheumatoid arthritis: assessment of several traditional risk parameters and a German risk score model.

    abstract::The present cross-sectional data demonstrate cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). The cross-sectional data were part of an interventional trial that included 100 patients with defined RA. Traditional CV risk parameters and risk score calculation for the German population were used to as...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Willers J,Hahn A

    更新日期:2012-12-01 00:00:00

  • Comparison of an administrative algorithm for SLE disease severity to clinical SLE Disease Activity Index scores.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Speyer CB,Li D,Guan H,Yoshida K,Stevens E,Jorge AM,Everett BM,Feldman CH,Costenbader KH

    更新日期:2020-02-01 00:00:00

  • Mononuclear cells recovered from inflammatory synovial membrane using fine-needle biopsy.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Geborek P,Sandberg M,Wollheim FA

    更新日期:1988-01-01 00:00:00

  • Evaluating standards of care in psoriatic arthritis of the QUANTUM project (qualitative initiative to improve outcomes): results of an accreditation project in Spain.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: García EI,Guilabert M,Queiro R,Carrillo I,Mira JJ

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Gerber A,Groneberg DA,Klingelhöfer D,Bundschuh M

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  • Establishing hospital admission criteria of pediatric Henoch-Schonlein purpura.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Masarweh K,Horovitz Y,Avital A,Spiegel R

    更新日期:2014-11-01 00:00:00