Celecoxib inhibits nitric oxide production in chondrocytes of ligament-damaged osteoarthritic rat joints.

abstract：:To date, numerous genetic and epigenetic studies have been performed and provided a crucial step forward in our understanding of the pathogenesis of rheumatic diseases. However, most of the recent advances in the treatment of rheumatic diseases including biological therapies are not based on or even discrepant from th...

journal_title：Rheumatology international

authors： Kato M,Yasuda S,Atsumi T

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:There is an overall increased risk of adverse pregnancy outcomes and maternal morbidity in patients with most autoimmune rheumatic diseases (ARD); outcomes are generally improved when the pregnancy is planned and the disease is in control. OBJECTIVE:The objective of the present study was to describe the sex...

journal_title：Rheumatology international

authors： Skinner-Taylor CM,Perez-Barbosa L,Barriga-Maldonado ES,Cardenas-de la Garza JA,Diaz-Angulo JE,Figueroa-Parra G,Riega-Torres J,Galarza-Delgado DA

更新日期：2021-02-01 00:00:00

abstract：:We have investigated the role of the Th17-related cytokines interleukin-17A (IL-17A), IL-21, and IL-23 in spondyloarthritis (SpA) by examining their association with disease activity and magnetic resonance imaging (MRI) findings in patients with SpA (n = 80). Furthermore, to investigate the cellular origins of the cyt...

journal_title：Rheumatology international

authors： Andersen T,Rasmussen TK,Hvid M,Holm CK,Madsen KJ,Jurik AG,Hokland M,Stengaard-Pedersen K,Schiøttz-Christensen B,Deleuran B

更新日期：2012-02-01 00:00:00

abstract：:A period of 4 weeks (w) has been recommended for rheumatoid arthritis (RA) patients as the interval between intravenous (IV) tocilizumab (TCZ, 8 mg/kg). In a previous paper, we showed the possibility that the interval between successive IV TCZ can be extended from 4 to 6 weeks in more than 60% of patients with low dis...

journal_title：Rheumatology international

authors： Saiki O,Uda H

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:To identify recommendations on the diagnosis and management of rheumatoid arthritis (RA) supported by low recommendation grades, to study the causes of this low grading, and to propose solutions. METHODS:A group of six rheumatologists, with extensive experience in the development of systematic reviews, revi...

journal_title：Rheumatology international

authors： Ortiz AM,Silva Fernández L,Villaverde V,Abad MÁ,Maneiro JR,Candelas G,Gómez S,Valderrama M,Montoro M

更新日期：2021-01-01 00:00:00

abstract：:Alpha 1-antitrypsin (A1AT) is the most abundant proteinase inhibitor in plasma and the main inhibitor of Proteinase 3, the target antigen of antineutrophil cytoplasmic antibodies (ANCAs) that predominant in Wegeners' granulomatosis. Α1AT deficiency correlated with ANCA-associated vasculitis. This study explores the tr...

journal_title：Rheumatology international

authors： Mota A,Sahebghadam Lotfi A,Jamshidi AR,Najavand S

更新日期：2014-04-01 00:00:00

abstract：:It is proposed that synovial fluid biomarkers may help in differentiating the type of arthritis. The aim of study is to determine whether synovial fluid adenosine deaminase (ADA) and high-sensitivity C-reactive protein (hs-CRP) can be useful in this regard. A total of 75 patients with knee monoarthritis that were admi...

journal_title：Rheumatology international

authors： Zamani B,Jamali R,Ehteram H

更新日期：2012-01-01 00:00:00

abstract：:The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease seve...

journal_title：Rheumatology international

authors： Banford JC,Brown DH,Hazelton RA,McNeil CJ,Smith WE,Sturrock RD

更新日期：1982-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathogenesis of fibrosis, inflammation and vascular abnormalities. This study was aimed to investigate the relation between SSc and Rho/Rho-kinase gene po...

journal_title：Rheumatology international

authors： Pehlivan Y,Yolbas S,Cetin GY,Alibaz-Oner F,Cagatay Y,Yilmaz N,Oztuzcu S,Donmez S,Ozgen M,Koca SS,Pamuk ON,Sayarlıoglu M,Kisacik B,Direskeneli H,Demiryurek AT,Onat AM

更新日期：2016-03-01 00:00:00

abstract：:The aim of this study was to determine the association between individual and external exposure factors, and the reporting of Raynaud's phenomenon, with or without concomitant cold sensitivity. In a population-based nested case-control study, cases with Raynaud's phenomenon (N = 578), and matched controls (N = 1156), ...

journal_title：Rheumatology international

authors： Stjernbrandt A,Pettersson H,Liljelind I,Nilsson T,Wahlström J

更新日期：2019-02-01 00:00:00

abstract：:Neopterin levels of serum and fluid were determined in 30 patients with inflammatory synovial fluids and in 30 controls with joint effusions induced by trauma or osteoarthritis. Neopterin was significantly elevated in inflammatory fluids. There was no correlation with the acute phase reactants. Neopterin levels were s...

journal_title：Rheumatology international

authors： Maerker-Alzer G,Diemer O,Strümper R,Rohe M

更新日期：1986-01-01 00:00:00

abstract：:To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...

journal_title：Rheumatology international

authors： Kumm J,Tamm A,Lintrop M,Tamm A

更新日期：2013-04-01 00:00:00

abstract：:The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evid...

journal_title：Rheumatology international

authors： Palmer DG,Hogg N,Denholm I,Allen CA,Highton J,Hessian PA

更新日期：1987-01-01 00:00:00

abstract：:Although exercise is often recommended for managing osteoarthritis (OA), limited evidence-based exercise options are available for older adults with OA. This study compared the effects of Hatha yoga (HY) and aerobic/strengthening exercises (ASE) on knee OA. Randomized controlled trial with three arms design was used: ...

journal_title：Rheumatology international

authors： Cheung C,Wyman JF,Bronas U,McCarthy T,Rudser K,Mathiason MA

更新日期：2017-03-01 00:00:00

abstract：:Nitric oxide (NO) is a free radical that plays important roles in many physiological and pathological processes. Evidence suggests that NO participates in the pathogenesis of inflammatory reactions in many autoimmune and inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this study was to evaluate...

journal_title：Rheumatology international

authors： Onur O,Akinci AS,Akbiyik F,Unsal I

更新日期：2001-05-01 00:00:00

abstract：:Non-tuberculous mycobacteria (NTM) are an unusual cause of osteomyelitis in immunocompetent children. Diagnosis is often difficult due to the paucity of clinical symptoms and a subtle course of the disease. NTM comprise a group of about 91 identified species of environmental mycobacteria that cause infections most fre...

journal_title：Rheumatology international

authors： Breda L,de Michele G,Nozzi M,De Sanctis S,Di Marzio D,Chiarelli F

更新日期：2009-10-01 00:00:00

abstract：:Idiopathic granulomatous mastitis is an inflammatory mass in the breast. Patients typically present with a firm breast mass, often associated with inflammation of the overlying skin. Nipple retraction, peau d'orange-like changes, and axillary adenopathy may be present. We describe a 23-year-old pregnant woman with art...

journal_title：Rheumatology international

authors： Salesi M,Karimifar M,Salimi F,Mahzouni P

更新日期：2011-08-01 00:00:00

abstract：:Crystalglobulinemia is an extremely rare pathology that is associated in most cases with plasma cell dyscrasia, mainly multiple myeloma. In most cases, it may be the manifestation of incipient gammopathy or it manifests shortly after diagnosis. We report a patient with ischemic lesions of thrombotic origin in lower li...

journal_title：Rheumatology international

authors： Gómez-Lechón Quirós L,Acosta De La Vega ME,Compán Fernández O,Pastor Navarro S,Montilla Morales C,Moyano Bueno D,Martín Centellas J,Santos-Briz Terrón A,Hidalgo Calleja C

更新日期：2020-08-01 00:00:00

abstract：:This retrospective medical chart review aimed to provide a current, real-world overview of biologic usage in patients with rheumatoid arthritis (RA) in Germany, Spain, and the UK, and estimate clinical and healthcare utilization outcomes associated with early versus late treatment. Adults (≥18 years) with a confirmed ...

journal_title：Rheumatology international

authors： Emery P,Solem C,Majer I,Cappelleri JC,Tarallo M

更新日期：2015-11-01 00:00:00

abstract：:Protein synthesis in all cells is readily interrupted by environmental stresses such as hyperthermia. However, stressed cells also have mechanisms which, even under conditions where normal protein synthesis is completely inhibited, allow them to synthesise a group of highly conserved proteins--the so-called heat shock...

journal_title：Rheumatology international

authors： Hurst NP

更新日期：1990-01-01 00:00:00

abstract：:We describe a typical case of a patient with remitting seronegative symmetrical synovitis and pitting edema (RS(3)PE) syndrome. He underwent a successful clinical course monitored by serologic variables and radiographic methods. Serum levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), matrix me...

journal_title：Rheumatology international

authors： Kawashiri SY,Nakano M,Kawakami A,Eguchi K

更新日期：2010-11-01 00:00:00

abstract：:Agalactosyl IgG [Gal(0)] was first discovered in patients with rheumatoid arthritis (RA). However, the proportion of this glycoform is also raised in tuberculosis and leprosy. This has helped reinforce the suggestion that RA may be triggered by a mycobacterium-like slow bacterial infection. On the other hand, arthriti...

journal_title：Rheumatology international

authors： McCulloch J,Zhang YW,Dawson M,Harkiss GD,Peterhans E,Vogt HR,Lydyard PM,Rook GA

更新日期：1995-01-01 00:00:00

abstract：:Neurocognitive dysfunction and brain injury on magnetic resonance imaging (MRI) are common in patients with systemic lupus erythematosus (SLE) and are associated with increased morbidity and mortality. However, brain MRI is expensive, is restricted by payers, and requires high expertise. Neurocognitive assessment is a...

journal_title：Rheumatology international

authors： Roldan PC,Jung RE,Sibbitt WL,Qualls CR,Flores RA,Roldan CA

更新日期：2018-08-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity...

journal_title：Rheumatology international

authors： Her MY,El-Sohemy A,Cornelis MC,Kim TH,Bae SC

更新日期：2006-11-01 00:00:00

abstract：:The diagnosis of Kawasaki disease (KD), a common pediatric vasculitis, is based solely on clinical criteria. There is a need for a robust laboratory marker that can help differentiate KD from other acute, febrile, childhood illnesses and also to predict cardiac involvement. We conducted a cross-sectional study of 25 c...

journal_title：Rheumatology international

authors： Reddy M,Singh S,Rawat A,Sharma A,Suri D,Rohit MK

更新日期：2016-04-01 00:00:00

abstract：:Our study was aimed to clarify an association between gastrointestinal (GI) amyloid-positive area and various kinds of factors including renal function in reactive amyloidosis associated with rheumatoid arthritis (RA). Twenty-five patients with an established diagnosis of reactive AA amyloidosis participated in the st...

journal_title：Rheumatology international

authors： Kuroda T,Tanabe N,Kobayashi D,Sato H,Wada Y,Murakami S,Nakano M,Narita I

更新日期：2012-04-01 00:00:00

abstract：:The atrioventricular conduction time (P-R interval) was determined in 189 women and 90 men with rheumatoid arthritis (RA). Only three women and one man were found to have pathological prolongation of the P-R interval. However, a significant prolongation of the P-R interval, within normal range, was seen in women with ...

journal_title：Rheumatology international

authors： Jurik AG,Møller P

更新日期：1985-01-01 00:00:00

abstract：:Patients with rheumatoid arthritis (RA) are at increased risk of low bone density and fractures. This study identifies predictors of initiation of dual energy X-ray absorptiometry (DXA) testing in RA. We identified RA patients from the CORRONA registry with >or=1 year follow-up without reported DXA at study entry. The...

journal_title：Rheumatology international

authors： Aizer J,Reed G,Onofrei A,Harrison MJ

更新日期：2009-06-01 00:00:00

abstract：:The aim of this study was to investigate the association of three polymorphisms of CD154 with risk of SLE in Chinese population. The study population comprised 770 Chinese individuals, including 350 SLE patients and 420 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confi...

journal_title：Rheumatology international

authors： Xiang Y,Guo J,Peng YF,Huang HT,Lan Y,Wei YS

更新日期：2017-08-01 00:00:00

abstract：:We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic an...

journal_title：Rheumatology international

authors： Staud R,Ramos LG

更新日期：2001-04-01 00:00:00