Influenza A-associated bronchiolitis obliterans organizing pneumonia mimicking Wegener's granulomatosis.

Abstract:

:We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic antibodies (cANCA). The results of an open-lung biopsy were consistent with BOOP. Although BOOP has previously been described as one of the pulmonary manifestations of WG, other more specific histologic features of WG such as capillaritis or necrotizing vasculitis were lacking. Because influenza A virus was cultured from the patient's lung tissue, final assessment of the illness focused on this as the etiologic agent triggering the pulmonary syndrome. The presence of ANCA was considered to be nonspecific. The patient's condition improved with appropriate therapy for BOOP.

journal_name

Rheumatol Int

authors

Staud R,Ramos LG

doi

10.1007/s002960000095

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

125-8

issue

3

eissn

0172-8172

issn

1437-160X

journal_volume

20

pub_type

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