Abstract：
:To date, numerous genetic and epigenetic studies have been performed and provided a crucial step forward in our understanding of the pathogenesis of rheumatic diseases. However, most of the recent advances in the treatment of rheumatic diseases including biological therapies are not based on or even discrepant from these genetic and epigenetic findings. For example, tumor necrosis factor inhibitors are quite successful in the treatment of rheumatoid arthritis (RA), Behçet's disease (BD), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) but not in that of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren's syndrome (SS) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV), conversely, RA shares genetic backgrounds more with SLE, SSc, SS and AAV than BD, AS and PsA. In this review, we briefly highlight the findings from recent genetic and epigenetic studies and discuss what needs to be studied to provide a novel, more efficacious management of rheumatic diseases.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kato M,Yasuda S,Atsumi Tdoi
10.1007/s00296-018-4026-0subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1333-1338issue
8eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-018-4026-0journal_volume
38pub_type
杂志文章,评审abstract：:An abnormal immune response towards the Epstein-Barr virus (EBV) has been documented in patients with rheumatoid arthritis (RA). To investigate whether these findings are due to the transformation event caused by EBV, RA blood mononuclear cells and monocyte-enriched preparations were incubated with two different EBV s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00271873
更新日期：1989-01-01 00:00:00
abstract：:The aim of this study is to determine whether and to which extent pentosidine (PEN) is influenced in the case of advanced osteoarthritis (OA) in urine and in some tissues. Reverse phase HPLC method for PEN determination with fluorescence monitoring was utilized. Urinary pentosidine (U-PEN) and pyridinoline (U-PD) were...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0105-8
更新日期：2006-08-01 00:00:00
abstract：:The aim of this study is to investigate whether eutectic mixture of local anesthetics (EMLA) cream phonophoresis superior to conventional US over the trigger points (TPs) in terms of improvements of pain, range of motion and disability in myofascial pain syndrome (MPS). Fifty patients (42 female, 8 male) diagnosed wit...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-013-2881-2
更新日期：2014-04-01 00:00:00
abstract：:Fibromyalgia is a multi-factorial illness primarily characterised by widespread chronic pain and fatigue, with several symptoms and associated conditions. Due to a lack of clinical awareness and an absence of objective diagnostic measures, fibromyalgia patients often engage with online health information. The aim is t...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04265-0
更新日期：2019-04-01 00:00:00
abstract：:In a prospective study 222 sera from 56 patients with systemic lupus erythematosus (SLE) were tested for antibodies to poly(A), poly dAT and histones using enzyme-linked immunosorbent assay (ELISA). Patients with active disease had significantly more often antibodies to poly(A), poly dAT and histones than patients wit...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541200
更新日期：1984-01-01 00:00:00
abstract：:Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,评审
doi：10.1007/BF02274749
更新日期：1990-01-01 00:00:00
abstract：:Low molecular weight IgM (LMW IgM) is the monomeric subunit of the naturally occurring pentameric IgM. It is not seen in health but has been previously observed in systemic lupus erythematosus (SLE) particularly in those patients with active disease and may reflect an adverse prognostic finding. We have therefore stud...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274821
更新日期：1990-01-01 00:00:00
abstract：:Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1954-3
更新日期：2012-06-01 00:00:00
abstract：:This study evaluates prospectively whether baseline scores [Health Assessment Questionnaire (HAQ) and SF-36] can predict clinical and radiographic evolution in a cohort of early rheumatoid arthritis (RA) during a 3-year follow-up. Forty consecutive early RA patients were followed for 3 years, while receiving standardi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2261-8
更新日期：2012-12-01 00:00:00
abstract：:Sleep disturbances and problems are increased in ankylosing spondylitis (AS). But much is not known in a quantitative way about sleep problems and effect of treatments on AS. This study is aimed first, to investigate sleep disturbances in AS and secondly, to evaluate the effects of anti-TNF treatment on SD in AS. One ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1907-x
更新日期：2012-07-01 00:00:00
abstract：:A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04414-5
更新日期：2019-12-01 00:00:00
abstract：:Knee osteoarthritis is a common disease in the elderly population worldwide. The alleviation of the symptoms associated with this disease can be achieved with physical exercise that induces a cascade of molecular and cellular processes. Of the neurotrophins, brain-derived neurotrophic factor (BDNF) appears to be the m...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2786-0
更新日期：2014-06-01 00:00:00
abstract：:Increased QT interval dispersion has been associated with an increased risk for ventricular arrhythmias and sudden cardiac events. We examined the QT interval dispersion in 20 North Indian children with Kawasaki disease (KD) with no coronary artery abnormalities on echocardiography compared the same with matched contr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1252-5
更新日期：2011-03-01 00:00:00
abstract：:Low-dose radiotherapy (LD-RT) has been widely used for treatment of non-malignant disorders since its introduction and animal studies show anti-inflammatory effects in osteoarthritis (OA). However, the evidence for its effect in clinical practice remains unclear. Therefore, the aim of this study is to systematically s...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3337-7
更新日期：2016-01-01 00:00:00
abstract：:Using different monoclonal antibodies, we performed an immunofluorescent technique on labial salivary glands in order to investigate the immunological phenomena involved in Sjögren's syndrome (SS). An aberrant expression of HLA-DR molecules was detected on cytoplasm of epithelial labial salivary cells in 9 out of 19 (...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00262708
更新日期：1995-01-01 00:00:00
abstract：:This study investigated the prevalence of antibody against annexin II (A2) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored the role of this antibody in thrombosis. Purified recombinant A2 was used in ELISA to measure the levels of IgG anti-A2 antibody in 101 AP...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1379-4
更新日期：2011-07-01 00:00:00
abstract：:Splenectomy may be necessary to treat systemic lupus erythematosus (SLE) patients with thrombocytopenia; however, whether performing a splenectomy on patients without SLE increases the subsequent risk of SLE remains unknown. Therefore, this study was conducted to determine the association between splenectomy and SLE. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3388-9
更新日期：2016-02-01 00:00:00
abstract：:Infliximab, a monoclonal chimeric anti-tumor necrosis factor alpha (anti-TNF-alpha) antibody, was tried in two patients suffering from severe refractory juvenile ankylosing spondylarthritis with disease duration of more than 10 years. To assess the response, validated clinical activity parameters were monitored prospe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0378-0
更新日期：2004-05-01 00:00:00
abstract：:Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement is very rare in sarcoidosis. The objective of this report was to evaluate a rare involvement of sarcoidosis. This report includes a case of nasopharyngeal sarcoidosis. A 51-year-old female with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1866-2
更新日期：2012-05-01 00:00:00
abstract：:Therapeutics targeting sphingosine-1-phosphate (S1P), a kind of lipid mediator regulating immune cell trafficking, has been emerging rapidly as a novel line of regimen for autoimmune diseases, including rheumatoid arthritis (RA). Here, we propose that S1P-targeted therapy is beneficial not only for limiting inflammati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1634-8
更新日期：2011-07-01 00:00:00
abstract：:In a study of 199 patients with rheumatoid arthritis, 68% were found to have tried 'alternative treatments'. Some treatments (acupuncture and faith healing) gave subjective benefit in nearly half those who tried them and were considered to be better than others (such as copper bracelets). No adverse reactions were rep...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541593
更新日期：1983-01-01 00:00:00
abstract：:A fifteenth-century Florentine altarpiece painted by the Pollaiuolo brothers, Antonio (1433-1498) and Piero (1443-1496), shows three saints with evident deformities of the hands and feet. The pathologies concerned are tentatively identified, and various rationales for their presence in the painting are discussed. Of p...
journal_title：Rheumatology international
pub_type： 历史文章,杂志文章
doi：10.1007/s00296-016-3599-8
更新日期：2017-03-01 00:00:00
abstract：:Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were fi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541284
更新日期：1986-01-01 00:00:00
abstract：:Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270349
更新日期：1986-01-01 00:00:00
abstract：:Abnormal manifestations of central nervous system in system lupus erythematosus (SLE) patients are mainly caused by primary neuropsychiatric SLE (NP-SLE). We reported a new onset SLE patient who had secondary neuropsychiatric manifestations caused by Epstein-Barr virus (EBV) encephalitis. Although EBV has an uncertain...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1877-z
更新日期：2012-08-01 00:00:00
abstract：:The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observationa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3814-2
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:Neprilysin (neutral endopeptidase, 3:4:24:11, CD10) (NEP) is a Zn metallopeptidase linked to controlling inflammation through the degradation of neuropeptides involved in neurogenic inflammation of chronic rheumatic diseases. The aim of our study was to evaluate circulating activity and cellular expression of...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0447-z
更新日期：2005-06-01 00:00:00
abstract：:Fifty-five patients with systemic lupus erythematosus (SLE) were examined for antineutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IIF). Enzyme-linked immunosorbent assay (ELISA) for ANCA against myeloperoxidase (MPO), lactoferrin (LF), proteinase 3 (PR3), elastase (HLE), and bactericidal/perme...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100108
更新日期：2001-07-01 00:00:00
abstract：:A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270365
更新日期：1987-01-01 00:00:00
abstract：:When rheumatoid articular cartilage samples were incubated with normal peripheral blood monocytes and cultured synovial cells in the presence of recombinant human interleukin-1 (IL-1) in vitro, large numbers of monocytes were seen to be attached to the articular surface. Significant numbers of monocytes invaded the ca...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00290248
更新日期：1991-01-01 00:00:00
