Differential immunological response of patients with rheumatoid arthritis towards two different Epstein-Barr virus strains: inhibition of interleukin-1 release by the B95-8, but not the P3HR-1 virus strain.

Abstract:

:An abnormal immune response towards the Epstein-Barr virus (EBV) has been documented in patients with rheumatoid arthritis (RA). To investigate whether these findings are due to the transformation event caused by EBV, RA blood mononuclear cells and monocyte-enriched preparations were incubated with two different EBV strains: the transforming virus secreted by the cell line B95-8 and the virus released by the P3HR-1 cell line that is not able to transform due to a small deletion in the U2 region of the virus genome. Immunological response was determined by the production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) using ELISA and bioassay systems. There was a striking difference in cytokine measurements with a strong inhibition of IL-1 and TNF production after incubation with the B95-8 virus, but not the P3HR-1 virus. These data indicate that the disturbed reaction of the immune system towards EBV is either dependent on the full transformation of B cells in RA patients or alternatively due to the secretion of a cytokine inhibitor by the B95-8 cell line.

journal_name

Rheumatol Int

authors

Häupl T,Burmester GR,Hahn G,Feige U,Rordorf-Adam C,Kalden JR

doi

10.1007/BF00271873

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

153-60

issue

3-5

eissn

0172-8172

issn

1437-160X

journal_volume

9

pub_type

杂志文章
  • Macrophage activation syndrome in malaria.

    abstract::Macrophage activation syndrome (MAS) is a clinical syndrome caused by an excessive proliferation of T lymphocytes and well-differentiated macrophages; an entity distinct from malignant histiocytosis. Although rheumatologic conditions are the common cause of MAS, a wide range of infections are also seen to cause MAS. W...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1033-1

    authors: Dass R,Barman H,Duwarah SG,Choudhury V,Jain P,Deka NM,Murari M

    更新日期:2010-06-01 00:00:00

  • Involvement of soluble receptor activator of nuclear factor-κB ligand (sRANKL) in collagenase-induced murine osteoarthritis and human osteoarthritis.

    abstract::Joint destruction and excessive bone formation are associated with high expression of soluble receptor activator of nuclear factor-κB ligand (sRANKL). This study was undertaken to investigate the role of sRANKL in collagenase-induced osteoarthritis (CIOA) in mice and in patients with osteoarthritis (OA). The initial p...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1723-8

    authors: Dimitrova P,Toncheva A,Gyurkovska V,Ivanovska N

    更新日期:2012-05-01 00:00:00

  • Hand osteoarthritis in Chuvashian population: prevalence and determinants.

    abstract::The objectives of this study are to evaluate the prevalence of radiographic hand osteoarthritis (OA) in Chuvashian community-based sample and its associations with age, sex, body mass index (BMI), smoking, and alcohol consumption. The study population was comprised of Chuvashians (443 males, age 47.4 ± 17.0 years and ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-0920-9

    authors: Kalichman L,Kobyliansky E

    更新日期:2009-11-01 00:00:00

  • Cytokine profile in serum and synovial fluid of arthritis patients with Chlamydia trachomatis infection.

    abstract::Chlamydia trachomatis (Ct)-induced arthritis (CtIA) is characterized by persistent Ct infection, which stimulates secretion of cytokines in vitro. We therefore investigated whether CtIA patients have a unique cytokine profile in synovial fluid or serum in vivo. Because underlying Ct infection is overlooked in a high p...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-003-0393-1

    authors: Jendro MC,Raum E,Schnarr S,Köhler L,Zeidler H,Kuipers JG,Martin M

    更新日期:2005-01-01 00:00:00

  • Establishing hospital admission criteria of pediatric Henoch-Schonlein purpura.

    abstract::The current study aimed to define evidence-based admission criteria of pediatric Henoch-Schonlein purpura (HSP). In addition, we aimed to better characterize epidemiological and clinical features of pediatric HSP in Israel. We performed a retrospective cohort study of all children with HSP admitted during a 15 years p...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-014-2971-9

    authors: Masarweh K,Horovitz Y,Avital A,Spiegel R

    更新日期:2014-11-01 00:00:00

  • Ochronotic arthritis: case reports and review of the literature.

    abstract::Alkoptunuria is an inherited autosomal recessive metabolic disorder which is caused by the lack of homogentisic acid-oxidase enzyme. It is associated with various systemic abnormalities and related to the deposition of homogentisic acid pigment in connective tissues. These pigmentary changes are termed "ochronosis". W...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-004-0538-x

    authors: Cetinus E,Cever I,Kural C,Erturk H,Akyildiz M

    更新日期:2005-08-01 00:00:00

  • Relationship of miRNA-146a to primary Sjögren's syndrome and to systemic lupus erythematosus: a meta-analysis.

    abstract::Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE) are common systemic autoimmune diseases, which impact not only patient health but also their quality of life. miRNA-146a is a microRNA that participates in the pathophysiology of SjS and SLE. In this investigation, we conducted a meta-analysis to determin...

    journal_title:Rheumatology international

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00296-017-3756-8

    authors: Sun HY,Lv AK,Yao H

    更新日期:2017-08-01 00:00:00

  • Cytokine enhancement of monocyte/synovial cell attachment to the surface of cartilage: a possible trigger of pannus formation in arthritis.

    abstract::When rheumatoid articular cartilage samples were incubated with normal peripheral blood monocytes and cultured synovial cells in the presence of recombinant human interleukin-1 (IL-1) in vitro, large numbers of monocytes were seen to be attached to the articular surface. Significant numbers of monocytes invaded the ca...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF00290248

    authors: Ishikawa H,Ohno O,Saura R,Matsubara T,Kuroda T,Hirohata K

    更新日期:1991-01-01 00:00:00

  • Effect of anti-TNF treatment on sleep problems in ankylosing spondylitis.

    abstract::Sleep disturbances and problems are increased in ankylosing spondylitis (AS). But much is not known in a quantitative way about sleep problems and effect of treatments on AS. This study is aimed first, to investigate sleep disturbances in AS and secondly, to evaluate the effects of anti-TNF treatment on SD in AS. One ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-1907-x

    authors: Karadağ O,Nakas D,Kalyoncu U,Akdoğan A,Kiraz S,Ertenli I

    更新日期:2012-07-01 00:00:00

  • Perception, knowledge, and use by general practitioners of Belgium of a new WHO tool (FRAX) to assess the 10-year probability of fracture.

    abstract::The FRAX tool that calculates the 10-year probability of having a fracture has recently been validated for Belgium. Little is known about the perception and knowledge that GPs have about this tool in their daily practice. A survey has been conducted as part of a screening campaign for various diseases. The primary obj...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2461-x

    authors: Bruyère O,Nicolet D,Compère S,Rabenda V,Jeholet P,Zegels B,Maassen P,Pire G,Reginster JY

    更新日期:2013-04-01 00:00:00

  • Adrenocorticotropic hormone: an effective "natural" biologic therapy for acute gout?

    abstract::Treatment of acute gout consists of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and steroids. However, the typical patient with gout has multiple comorbidities such as cardiovascular disease, hypertension, renal dysfunction or diabetes/metabolic syndrome that represent contraindications to these therape...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-020-04659-5

    authors: Daoussis D,Bogdanos DP,Dimitroulas T,Sakkas L,Andonopoulos AP

    更新日期:2020-12-01 00:00:00

  • Diabetic muscular infarct: an unusual cause of extremity pain and dysfunction.

    abstract::Diabetic muscular infarct (DMI) is a rare condition, which begins with acute onset of extremity pain and swelling. Patients usually have long-standing disease and poorly controlled diabetes mellitus (DM). Thigh muscle group is the most commonly involved side, while lower leg involvement is rare. We represent herein a ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1759-9

    authors: Uçan H,Alemdaroğlu E,Yoldaş TK,Erdem Özdamar S,Akyüz M,Hatipoğlu C

    更新日期:2012-02-01 00:00:00

  • Ochronosis in differential diagnosis of patients with chronic backache: a review of the literature.

    abstract::A 50-year-old man presented with a complaint of low-back pain and widespread joint pain for the previous 20 years. Conventional radiography revealed wide areas of calcification in the intervertebral discs and degenerative changes in the peripheral joints. A diagnosis of ochronosis was made by the observation of bluish...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-007-0381-y

    authors: Capkin E,Karkucak M,Yayli S,Serdaroğlu M,Tosun M

    更新日期:2007-11-01 00:00:00

  • Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis.

    abstract::This study investigated the prevalence of antibody against annexin II (A2) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored the role of this antibody in thrombosis. Purified recombinant A2 was used in ELISA to measure the levels of IgG anti-A2 antibody in 101 AP...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1379-4

    authors: Ao W,Zheng H,Chen XW,Shen Y,Yang CD

    更新日期:2011-07-01 00:00:00

  • Circulating endothelial progenitor cells are reduced in SLE in the absence of coronary artery calcification.

    abstract::Circulating endothelial progenitor cells (EPCs) are reduced in patients with systemic lupus erythematosus (SLE). A reduced number of EPCs are associated with the presence of atherosclerosis in other populations. We sought to determine whether the reduction in EPC numbers in SLE is dependent on the presence of advanced...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1730-9

    authors: Baker JF,Zhang L,Imadojemu S,Sharpe A,Patil S,Moore JS,Mohler ER 3rd,Von Feldt J

    更新日期:2012-04-01 00:00:00

  • Anaplastic large cell lymphoma in a patient with rheumatoid arthritis.

    abstract::It is known that patients with rheumatoid arthritis (RA) have an increased risk for non-Hodgkin's lymphomas in comparison with the general population. Although increased risk of lymphoma is attributed to the disease activity, the drugs used in the therapy of RA may also cause increased risk of malignancy. Herein, we r...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1184-0

    authors: Bes C,Bes ZS,Vardı S,Soy M

    更新日期:2011-04-01 00:00:00

  • One-year direct costs of biological therapy in rheumatoid arthritis and its predictive factors: data from the Moroccan RBSMR registry.

    abstract::The aim of the study was to estimate the annual direct costs of biological therapies in rheumatoid arthritis (RA), and to establish possible factors associated with those costs. The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry). We included patients with avai...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-020-04762-7

    authors: Fellous S,Rkain H,Ahid S,Abouqal R,Tahiri L,Hmamouchi I,Achemlal L,El Bouchti I,El Maghraoui A,Ghozlani I,Hassikou H,Harzy T,Ichchou L,Mkinsi O,Niamane R,Bahiri R,Allali F

    更新日期:2021-01-02 00:00:00

  • Sequelae of osteomyelitis variolosa: a case report.

    abstract::Osteomyelitis variolosa is an osteoarticular complication of small pox infection. We are presenting a case of osteomyelitis variolosa, who presented to us with fracture of ankle on the involved side with other orthopedic sequelae of small pox infection, which he contracted during his childhood period. We have discusse...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2194-2

    authors: Nema S,Vyas GS,Kukreja S

    更新日期:2012-11-01 00:00:00

  • Diagnostic/classification criteria in pediatric Behçet's disease.

    abstract::Behçet's disease (BD) is a variable vessel vasculitis characterized by recurrent oral and genital aphthosis accompanied by skin, ocular, gastrointestinal, neurologic, and articular involvement. BD is not common in childhood and the disease characteristics considerably differ between adults and children. 18 diagnostic/...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-018-4208-9

    authors: Batu ED

    更新日期:2019-01-01 00:00:00

  • Infection and autoimmune disease.

    abstract::Most infectious agents, such as viruses, bacteria and parasites, can trigger autoimmunity via different mechanisms. The development of an autoimmune disorder after infection tends to occur in genetically susceptible individuals. Some parameters, such as genetic predisposition, feature of the infectious agent and somet...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-012-2451-z

    authors: Sener AG,Afsar I

    更新日期:2012-11-01 00:00:00

  • Rheumatoid factor isotype and Ro epitope distribution in primary Sjögren syndrome and rheumatoid arthritis with keratoconjunctivitis sicca.

    abstract::Primary Sjögren syndrome (pS) is associated with autoantibodies such as rheumatoid factor (RF) and anti-nuclear antibodies such as anti-Ro (SS-A) and/or La (SS-B). Recent developments within autoimmune diagnostics allow quantitation of RF subclasses and anti-Ro epitopes. Will this refinement by autoimmune diagnostics ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-018-4090-5

    authors: Meek B,Kelder JC,Claessen AME,van Houte AJ,Ter Borg EJ

    更新日期:2018-08-01 00:00:00

  • Treatment efficacy of etanercept and MTX combination therapy for ankylosing spondylitis hip joint lesion in Chinese population.

    abstract::To investigate the efficacy of etanercept and MTX (methotrexate) combination therapy in Chinese patients with ankylosing spondylitis hip joint lesion, the possible courses and maintenance protocol, altogether 97 ankylosing spondylitis patients fulfilling the modified New York criteria with hip joint lesion were enroll...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-1844-8

    authors: Lian F,Yang X,Liang L,Xu H,Zhan Z,Qiu Q,Ye Y

    更新日期:2012-06-01 00:00:00

  • Systemic necrotizing vasculitides in Turkey: a comparative analysis of 40 consecutive patients.

    abstract:OBJECTIVE:The aim of this study was to analyze and compare the demographic and clinical features and prognosis of patients with different systemic necrotizing vasculitides (SNV) in Turkey. PATIENTS AND METHODS:Twenty-three patients with Wegener's granulomatosis (WG), 15 with polyarteritis nodosa (PAN), and two with Ch...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-004-0499-0

    authors: Kamali S,Inanc M,Gul A,Ocal L,Polat NG,Kilicaslan I,Aral O,Konice M

    更新日期:2005-11-01 00:00:00

  • Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results.

    abstract::The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an excessive regional inflammation, sensitization of primary somatosensory afferents, and sensitization of spinal neurons are considered to have a role in the pathogenesis of RSD. The underlying pathophysiology relating the c...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-005-0009-z

    authors: Okudan B,Celik C

    更新日期:2006-03-01 00:00:00

  • Catalase and PPARgamma2 genotype and risk of rheumatoid arthritis in Koreans.

    abstract::Catalase (CAT) and peroxisome proliferator activated receptor-gamma2 (PPARgamma2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARgamma2 genotypes and risk and severity of RA using 474...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-005-0013-3

    authors: El-Sohemy A,Cornelis MC,Park YW,Bae SC

    更新日期:2006-03-01 00:00:00

  • Extra-articular manifestations in 587 Italian patients with rheumatoid arthritis.

    abstract::The aim of the study was to evaluate the frequency of extra-articular manifestations (EAMs) of rheumatoid arthritis (RA) in a series of patients from nine Italian rheumatology clinics. A total of 587 patients underwent direct questioning, complete physical evaluation, and review of medical records and laboratory data....

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/pl00006853

    authors: Cimmino MA,Salvarani C,Macchioni P,Montecucco C,Fossaluzza V,Mascia MT,Punzi L,Davoli C,Filippini D,Numo R

    更新日期:2000-01-01 00:00:00

  • Anti-Saccharomyces cerevisiae antibodies in patients with systemic lupus erythematosus.

    abstract::Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease but it has been found in many other autoimmune diseases like systemic lupus erythematosus (SLE). Furthermore, cross-reactive epitopes on β2-glycoprotein I (β2GPI) and Saccharomyces cerevisiae were found in SLE patients. T...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2431-3

    authors: Mankaï A,Sakly W,Thabet Y,Achour A,Manoubi W,Ghedira I

    更新日期:2013-03-01 00:00:00

  • The sensitivity, specificity and accuracy of anti-citrulline antibody test in diagnosis of rheumatoid arthritis.

    abstract::Citrulline antibody, nowadays, is a new item which has been the center of attention due to its much more specificity to diagnose RA. The aim of the present study was to evaluate the efficacy and accuracy of anti-citrulline antibody test in RA diagnosis among hospitalized patients in Iran. Through a case-control study,...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2469-2

    authors: Abolghasemi S,Gitipour A,Morteza A

    更新日期:2013-04-01 00:00:00

  • Osteoporosis in chronic liver disease: a case-control study.

    abstract::Osteoporosis has become an increasingly recognized complication among patients with chronic liver disease (CLD). The aim of the present study was to assess the prevalence and risk factors of osteoporosis in patients with CLD (primary biliary cirrhosis and chronic viral hepatitis B or C patients) in comparison with a g...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1071-8

    authors: Wariaghli G,Mounach A,Achemlal L,Benbaghdadi I,Aouragh A,Bezza A,El Maghraoui A

    更新日期:2010-05-01 00:00:00

  • Blockade of intra-articular adrenergic receptors increases analgesic demands for pain relief after knee surgery.

    abstract::Activation of opioid receptors on peripheral sensory nerve terminals by opioid peptides that are produced and released from immune cells can result in inhibition of inflammatory pain. This study tests the hypothesis that postoperative pain is attenuated endogenously through a local sympathetic neurotransmitter-activat...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00296-010-1489-z

    authors: Kager I,Mousa SA,Sieper J,Stein C,Pipam W,Likar R

    更新日期:2011-10-01 00:00:00