Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality?


:We describe the case of a 59 year old man with systemic sclerosis and superficial siderosis of the central nervous system characterized by progressive worsening of walking with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia. Ferritin and oligoclonal bands were found on lumbar puncture and Magnetic Resonance Imaging of the brain and spinal cord revealed a rim of hypointensity in T2-weighted images enveloping the surface of brain and spinal cord, typical of hemosiderosis. Neurological complications, both central and peripheral, are thought to be rare and coincidental in systemic sclerosis; however over the past decade, some authors have reported a high incidence (up to 40%) of neurological involvement in the disease. In this report we consider the hypothesis that superficial siderosis may be a direct complication of systemic sclerosis. To our knowledge, this case represents the first description of superficial siderosis in a patient with systemic sclerosis.


Rheumatol Int


Simeoni S,Puccetti A,Tinazzi E,Tomelleri G,Corrocher R,Lunardi C




Has Abstract


2008-06-01 00:00:00












  • Current understanding and future perspectives of brain-heart-kidney axis in psoriatic arthritis.

    abstract::Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA reve...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Markousis-Mavrogenis G,Nurmohamed MT,Koutsogeorgopoulou L,Dimitroulas T,Katsifis G,Vartela V,Mitsikostas D,Kolovou G,Tektonidou M,Voulgari P,Sfikakis PP,Kitas GD,Mavrogeni SI

    更新日期:2020-09-01 00:00:00

  • Adherence to best practice consensus guidelines for familial Mediterranean fever: a modified Delphi study among paediatric rheumatologists in Turkey.

    abstract:BACKGROUND:Although not validated fully, recommendations are present for diagnosis, screening and treatment modalities of patients with familial Mediterranean fever (FMF). OBJECTIVE:To review the current practices of clinicians regarding FMF and reveal their adherence to consensus guidelines. METHODS:Fifteen key poin...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kavrul Kayaalp G,Sozeri B,Sönmez HE,Demir F,Cakan M,Oztürk K,Karadag SG,Otar Yener G,Ozdel S,Baglan E,Celikel E,Sahin N,Gezgin Yildirim D,Eker Omeroglu R,Aktay Ayaz N,PeRA-Research Group.

    更新日期:2021-01-16 00:00:00

  • Binding of antibodies raised against tumour necrosis factor alpha (TNF alpha) to blood vessels and macrophages in inflamed synovial tissue.

    abstract::The distribution of tumour necrosis factor alpha (TNF alpha) in rheumatoid synovium has been investigated. Ten rheumatoid synovia were compared with seven normal synovia and a range of other tissues, using one polyclonal and six monoclonal antibodies. A common staining pattern was obtained with five reagents. Absence ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Wilkinson LS,Edwards JC

    更新日期:1991-01-01 00:00:00

  • Acute psycosis in systemic lupus erythematosus.

    abstract::Psychiatric manifestations are common in systemic lupus erythematosus (SLE) and often represent a challenging diagnostic and therapeutic problem, mainly because the uncertainties of the pathogenic mechanisms. We report a case of acute psychosis occurring in a female with SLE due to the stress of having a severe diseas...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Marasini B,Massarotti M

    更新日期:2008-02-01 00:00:00

  • Ultrasonography of peripheral entheses in the diagnosis and understanding of diffuse idiopathic skeletal hyperostosis (DISH).

    abstract::The aim of this study was to investigate musculoskeletal ultrasound (MSUS) as a diagnostic modality in DISH and to explore whether it might help in elucidating its pathogenesis and events that precede the calcification/ossification process. Fifty patients with DISH and 34 patients with osteoarthritis of the lower limb...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Mader R,Novofastovski I,Iervolino S,Pavlov A,Chervinsky L,Schwartz N,Pappone N

    更新日期:2015-03-01 00:00:00

  • Severe Henoch-Schönlein nephritis: resolution with azathioprine and steroids.

    abstract:AIM:The aim of this study was to assess the efficacy of long-term azathioprine and steroids for treatment of severe nephritis in children with Henoch-Schönlein purpura (HSP). METHODS:Analysis of case records of children with HSP followed up for a mean duration of 4.7 years (range 6 months-6.5 years) was performed. All...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Singh S,Devidayal,Kumar L,Joshi K,Minz RW,Datta U

    更新日期:2002-08-01 00:00:00

  • Patterns of circulatory and peripheral blood mononuclear cytokines in rheumatoid arthritis.

    abstract::An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Azizieh FY,Al Jarallah K,Shehab D,Gupta R,Dingle K,Raghupathy R

    更新日期:2017-10-01 00:00:00

  • Heart rate variability in patients with rheumatoid arthritis.

    abstract::Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Evrengül H,Dursunoglu D,Cobankara V,Polat B,Seleci D,Kabukçu S,Kaftan A,Semiz E,Kilic M

    更新日期:2004-07-01 00:00:00

  • In vivo 31P magnetic resonance spectroscopy (MRS) of tender points in patients with primary fibromyalgia syndrome.

    abstract::31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: de Blécourt AC,Wolf RF,van Rijswijk MH,Kamman RL,Knipping AA,Mooyaart EL

    更新日期:1991-01-01 00:00:00

  • Association of rheumatoid arthritis with hearing loss: a systematic review and meta-analysis.

    abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting up to 1% of the worldwide population. RA is associated with multiple extra-articular manifestations (EAMs). Middle ear, cochlea and the auditory nerve are suspected sites of RA activity and hearing loss is a possible novel EAM of RA. Objective was to...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Chaitidis N,Theocharis P,Festas C,Aritzi I

    更新日期:2020-11-01 00:00:00

  • MBD4 gene is associated with rheumatoid arthritis in Chinese patients in Taiwan.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Huang CM,Huang PH,Chen CL,Wan L,Tsai CH,Liu SC,Huang WL,Tsai FJ

    更新日期:2012-01-01 00:00:00

  • Correlation of neurocognitive function and brain lesion load on magnetic resonance imaging in systemic lupus erythematosus.

    abstract::Neurocognitive dysfunction and brain injury on magnetic resonance imaging (MRI) are common in patients with systemic lupus erythematosus (SLE) and are associated with increased morbidity and mortality. However, brain MRI is expensive, is restricted by payers, and requires high expertise. Neurocognitive assessment is a...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Roldan PC,Jung RE,Sibbitt WL,Qualls CR,Flores RA,Roldan CA

    更新日期:2018-08-01 00:00:00

  • Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

    abstract::Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Baker DA,Eudaly J,Smith CD,Obeid LM,Gilkeson GS

    更新日期:2013-10-01 00:00:00

  • Reduction in jaw opening: a neglected symptom of giant cell arteritis.

    abstract::Reduction in jaw opening is a neglected symptom of giant cell arteritis (GCA) in clinical practice and in the scientific literature. We describe the case of a 71-year-old woman with GCA who was misdiagnosed as occipital neuritis and craniomandibular dysfunction because of headaches in the occipital region and reductio...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kraemer M,Metz A,Herold M,Venker C,Berlit P

    更新日期:2011-11-01 00:00:00

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    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验


    authors: Calis M,Demir H,Ulker S,Kirnap M,Duygulu F,Calis HT

    更新日期:2006-04-01 00:00:00

  • Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study.

    abstract::Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and vasculopathy. A key feature is the presence of T cells in inflammatory lesions. To establish the differences in peripheral blood T helper (Th) subpopulations in diffuse cutaneous (dc) and limited cutaneous (lc) SSc patients, blood samples ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Rodríguez-Reyna TS,Furuzawa-Carballeda J,Cabiedes J,Fajardo-Hermosillo LD,Martínez-Reyes C,Díaz-Zamudio M,Llorente L

    更新日期:2012-09-01 00:00:00

  • Antibodies to arthritis-associated microbes in inflammatory joint diseases.

    abstract::IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Mäki-Ikola O,Viljanen MK,Tiitinen S,Toivanen P,Granfors K

    更新日期:1991-01-01 00:00:00

  • Inflammatory response in patients with active and inactive osteoarthritis.

    abstract::In the present study, we have investigated comparatively the inflammatory response of patients with active and inactive osteoarthritis. The sera from 31 healthy individuals, 37 patients with active OA, and 19 patients with inactive OA were assayed for TNF-alpha, IL-6, sRANKL, RANTES, and MRP8 using ELISA in order to e...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Toncheva A,Remichkova M,Ikonomova K,Dimitrova P,Ivanovska N

    更新日期:2009-08-01 00:00:00

  • Sacral inflammatory pseudotumor revealed by paraneoplastic syndrome.

    abstract::There is still debate on whether inflammatory pseudotumor should be considered benign or malignant. This lesion has only been reported twice in bone, apart from cases complicating foreign body reaction to joint replacement arthroplasty. We report here a third case, localized at the sacrum. A 31-year-old man had inflam...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Allanore Y,Pham XV,Clerc DA,Menkès CJ,Kahan A

    更新日期:2004-05-01 00:00:00

  • DNA synthesis in CD4- and CD8-positive cells in synovial fluid of patients with reactive and rheumatoid arthritis.

    abstract::The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method comb...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Nordström DC

    更新日期:1989-01-01 00:00:00

  • Meigs' syndrome: a rare cause of recurrent pleural effusion in scleroderma.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Su F,Cummings KW,Krigman H,Ranganathan P

    更新日期:2013-10-01 00:00:00

  • Relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Giordano M,Valentini G,Sodano A

    更新日期:1984-01-01 00:00:00

  • Spondylodiscitis due to an emergent fungal pathogen: Blastoschizomyces capitatus, a case report and review of the literature.

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    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Celik AD,Ozaras R,Kantarcioglu S,Mert A,Tabak F,Ozturk R

    更新日期:2009-08-01 00:00:00

  • Primary Sjögren's syndrome in Moroccan patients: characteristics, fatigue and quality of life.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ibn Yacoub Y,Rostom S,Laatiris A,Hajjaj-Hassouni N

    更新日期:2012-09-01 00:00:00

  • Effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in individuals with knee osteoarthritis.

    abstract::Establishing prevention and therapeutic strategies for osteoarthritis (OA) is necessary to minimize functional disability and the impact of the disease on society. The aim of this study was to determine the effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Aguiar GC,Do Nascimento MR,De Miranda AS,Rocha NP,Teixeira AL,Scalzo PL

    更新日期:2015-03-01 00:00:00

  • Serum amyloid A--an indicator of inflammation in ankylosing spondylitis.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lange U,Boss B,Teichmann J,Klör HU,Neeck G

    更新日期:2000-01-01 00:00:00

  • R-h-erythropoietin counteracts the inhibition of in vitro erythropoiesis by tumour necrosis factor alpha in patients with rheumatoid arthritis.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Jongen-Lavrencic M,Peeters HR,Backx B,Touw IP,Vreugdenhil G,Swaak AJ

    更新日期:1994-01-01 00:00:00

  • QT interval dispersion in North Indian children with Kawasaki disease without overt coronary artery abnormalities.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ghelani SJ,Singh S,Manojkumar R

    更新日期:2011-03-01 00:00:00

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lee WJ,Cho HY,Lee YJ,Lee BR,Shin JP

    更新日期:2013-01-01 00:00:00

  • The value of cartilage biomarkers in progressive knee osteoarthritis: cross-sectional and 6-year follow-up study in middle-aged subjects.

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    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kumm J,Tamm A,Lintrop M,Tamm A

    更新日期:2013-04-01 00:00:00